Topical Collection "Molecular and Behavior Relationship in Gene-Manipulated Model Organisms"
Neuropsychiatric disorders, such as autism, epilepsy, schizophrenia, and Alzheimer’s disease, are primarily associated with a genetic predisposition. Over the past two decades, human genetic studies have identified candidate genes for the pathogenesis of these disorders. Behavioral studies using genetically modified animal models are widely used to verify the causal relationship between human mutations and disorders. Mice have been predominantly used as genetically modified disease models due to the ability of gene targeting in ES cells. In recent years, advances in genome editing technology have allowed recapitulating human mutations in various species, including worms, flies, fishes, rodents, and monkeys, and this enables us to study the large-scale collective behavior or higher cognitive functions. Viral-mediated region-specific gene manipulation also broadens the application of behavioral studies in various model organisms. In parallel, a wide variety of methods for behavioral studies combined with modern computer programming, such as machine learning, have also been established.
In this research topic, we invite original research articles or reviews related to behavioral studies using gene-manipulated model organisms. Research that is not directly related to diseases is also welcomed. We aim to share current advances and innovations in the research field.
Prof. Dr. Katsuhiko Tabuchi
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- model organism
- genome editing
- neuropsychiatric disorders