Role of Mitochondria Transfer in Health and Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 521
Special Issue Editor
Interests: mesenchymal stem cells; mitochondria; cell therapy; metabolism; cell-to-cell communication; tissue injury; tunneling nanotubes
Special Issue Information
Dear Colleagues,
Considered for a long time as the powerhouse of the cells devoted to energy production through oxidative phosphorylation, mitochondria have recently attracted the interest of scientists. Mitochondria contribute to a number of vital cellular process, including programmed cell death and calcium homeostasis. These fascinating organelles are key regulators of cell fate by adapting the synthesis of building blocks through the TCA cycle to the needs of the cells. During the past decade, it has been discovered that mitochondria can also regulate the functions of cells other than those that originally produced them, as mitochondria have been observed to have the ability to move between a wide variety of cells. As a result, these fascinating organelles control multifaceted biological processes including wound healing and inflammation, and their dysfunctions are associated with a broad range of diseases, including inherited mitochondrial disorders and metabolic diseases, such as diabetes and cancer. In addition, some new evidence indicates that cell-to-cell communication through intercellular mitochondria transfer spontaneously occurs in vivo and that this process is critical for the maintenance of tissue homeostasis.
This Special Issue proposes to offer an overview on the more recent findings on the role of intercellular mitochondria transfer in the physiological and pathological context and whether mitochondria transfer can be envisioned as a therapeutic approach to treat injured tissues, mitochondrial diseases, and cancer. The aim of this issue is to bring together the most recent and leading works on mitochondrial transfer and to highlight the therapeutic perspectives emerging from this area of investigation.
Dr. Anne-Marie Rodriguez
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- metabolism
- stem cells
- tissue homeostasis
- tissue repair
- cancer
