Signaling Pathways Responsible for Breast Cancer Metastasis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2284
Special Issue Editor
Interests: senescence; aging; microRNA; cancer stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast cancer is the most common disease among women and one of main leading causes of cancer-related death worldwide. Metastasis is widely accepted as the hallmark of cancer and considered to be responsible for recurrence and poor prognosis. The metastasis process consists of complex steps such as interaction with stromal cells, transition from epithelial to mesenchymal state, suppression immune cells, organ tropism, and colonization. Since the molecular mechanisms for metastasis process are not fully elucidated, it might be quite important to understand the biology of metastasis from various aspects. This Special Issue mainly focuses on the signaling pathway for breast cancer metastasis and aims to provide an overview of recent knowledge regarding each step of metastasis. In addition to the molecular principles of the metastasis process, we also focus on therapeutic and diagnostic approaches against breast cancer metastasis. This is because recent advances in the detection of circulating tumor cells and secreted DNAs/RNAs reveal that those molecules exert functional roles in the metastasis process and might be promising targets for cancer therapy and diagnosis.
This Special Issue of Cells will cover the following important aspects of breast cancer metastasis:
- Signaling pathways that regulate the metastatic ability of breast cancer cells;
- Epithelial to mesenchymal transition (EMT) regulators;
- Immune suppression mechanisms for breast cancer metastasis;
- Therapeutic and diagnostic approaches against breast cancer metastasis.
Dr. Ryou-u Takahashi
Guest Editor
Manuscript Submission Information
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Keywords
- EMT
- immune suppression
- organ tropism
- CTC
- secreted DNAs
- secreted RNAs
