Special Issue "Cellular Homeostasis and Quality Control"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 143

Special Issue Editors

Department of Biology, University of Fribourg, Chemin du Musée 10, CH-1700 Fribourg, Switzerland
Interests: membrane homeostasis; lipid droplet biogenesis; lipid transport; sterol export; CAP proteins; fatty acid transport
Denali Therapeutics, South San Francisco, CA, USA
Interests: mitochondrial dysfunction; lysosomal storage disorders; molecular chaperones; neurodegeneration; aging

Special Issue Information

Dear Colleagues,

The functioning of cells, as individual units or as components of complex tissue systems, rely on the maintenance of a steady and balanced physiological state. Such a state of homeostasis is enabled by a range of quality control mechanisms, responding to both internal as well as environmental changes that may disrupt optimal function. Cellular quality control ensures that subcellular components such as proteins are regulated at the level of synthesis, degradation as well as their precise localization. Similarly, cells regulate the uptake, synthesis and subcellular distribution of lipids and metabolites, allowing them to adapt to changing environments and respond to stress and damage. Achieving quality control also requires coordination between organelles performing diverse specialized functions. Thus, the maintenance of cellular homeostasis depends on a network of self-regulating feedback-controlled pathways and the failure of quality control mechanisms underlie numerous diseases afflicting millions of people worldwide. These include cancer, diabetes, and neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, to name a few.

We invite original research articles, reviews, as well as short perspective articles for a special issue on Cellular Homeostasis and Quality Control focusing on the following key areas:

  • Protein quality control: From chaperones to ubiquitin proteasome system to autophagy
  • Protein trafficking defects and human disease
  • Mitochondrial dysfunction and quality control
  • Lysosomal storage disorders
  • Cellular quality control and aging

In particular, submissions focusing on the failure of quality control pathways in relation to development and progression of human disease are particularly encouraged.

Prof. Dr. Roger Schneiter
Dr. Madhuja Samaddar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cellular homeostasis
  • protein trafficking and quality control
  • mitochondrial dysfunction
  • lysosomal storage disorders
  • neurodegeration
  • aging

Published Papers

This special issue is now open for submission.
Back to TopTop