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Cells
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Immunoregulatory Roles of Natural Killer (NK) Cells
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Immunoregulatory Roles of Natural Killer (NK) Cells

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 2374

Special Issue Editor

Prof. Dr. Subramaniam Malarkannan

E-Mail Website
Guest Editor
Medical College of Wisconsin, Milwaukee, WI, USA
Interests: innate immunity; NK cells; signaling; single-cell transcriptome; cell therapy; CAR-T/NK therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural killer (NK) cells are the major lymphocytes of the innate immune arm. NK cells mediate cytotoxic and inflammatory cytokine responses against malignant and infected cells. Their ability to regulate the immune functions of other lymphocytes are emerging. However, an in depth understanding and the associated molecular mechanisms are yet to be defined and appreciated. Is there a unique subset of NK cells that specialize in the functional regulation of other immune cells? If so, what transcriptional and transcriptomic pathways govern the development and functions of this NKReg cells? What specific roles these NKReg cells play in pathological conditions such as tumor growth or autoimmune disorders? Are there ways to manipulate these cells to obtain better clinical outcomes? Regulatory NK cells are the focus of this special issue, and we are confident that these exciting questions will provide translatable answers with therapeutic applications.

Prof. Dr. Subramaniam Malarkannan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • NK cells
  • regulatory NK subsets
  • effector functions of unique NK subsets
  • development of NK subsets
  • signaling and transcriptional regulation among NK subsets

Published Papers (1 paper)

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Research

18 pages, 2814 KiB  
Article
Inhibition of Glucose Uptake Blocks Proliferation but Not Cytotoxic Activity of NK Cells
by Lea Katharina Picard, Elisabeth Littwitz-Salomon, Herbert Waldmann and Carsten Watzl
Cells 2022, 11(21), 3489; https://doi.org/10.3390/cells11213489 - 3 Nov 2022
Cited by 1 | Viewed by 2090
Abstract
Tumor cells often have very high energy demands. Inhibition of glucose uptake is therefore a possible approach to limit the proliferation and survival of transformed cells. However, immune cells also require energy to initiate and to maintain anti-tumor immune reactions. Here, we investigate [...] Read more.
Tumor cells often have very high energy demands. Inhibition of glucose uptake is therefore a possible approach to limit the proliferation and survival of transformed cells. However, immune cells also require energy to initiate and to maintain anti-tumor immune reactions. Here, we investigate the effect of Glutor, an inhibitor of glucose transporters, on the function of human Natural Killer (NK) cells, which are important for the immunosurveillance of cancer. Glutor treatment effectively inhibits glycolysis in NK cells. However, acute treatment with the inhibitor has no effect on NK cell effector functions. Prolonged inhibition of glucose uptake by Glutor prevents the proliferation of NK cells, increases their pro-inflammatory regulatory function and reduces the stimulation-dependent production of IFN-γ. Interestingly, even after prolonged Glutor treatment NK cell cytotoxicity and serial killing activity were still intact, demonstrating that cytotoxic NK cell effector functions are remarkably robust against metabolic disturbances. Full article
(This article belongs to the Special Issue Immunoregulatory Roles of Natural Killer (NK) Cells)
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