Multidimensional Impact of Ionic Liquids on Cellular Dynamics: Integrating Cell Physiology, Molecular Biology, and Biophysics

Dear Colleagues,

In this Special Issue, we will explore the intricate interplay between ionic liquids and cellular processes within our engaging research topic, titled "Multidimensional Impact of Ionic Liquids on Cellular Dynamics: Integrating Cell Physiology, Molecular Biology and Biophysics." This extensive exploration is meticulously designed to unveil the myriad effects of ionic liquids, extending from fundamental cellular functions to the intricate realms of molecular and biophysical dynamics. We will create a comprehensive understanding by seamlessly integrating insights from cell physiology, molecular biology, and biophysics, providing a holistic perspective on how ionic liquids shape and influence cellular dynamics. In the realm of biological applications, challenges such as the toxicity, environmental impacts, and efficiency of traditional solvent systems impede progress. Innovative solutions, namely bioinspired ionic liquids and deep eutectic solvents, have emerged to overcome these hurdles. These solvents mimic biological efficiency, ensuring their compatibility with biomolecules, reduced toxicity, and precise control over interactions. Their transformative advantages over conventional solvents in biological applications are profound. The integration of bioinspired solvents has the potential to revolutionize the processes involved in regenerative medicine, wound healing, bone regeneration, and biological implants, offering eco-friendly alternatives for biomolecule stability, thus enhancing yields of bioactive compounds. This paradigm shift optimizes processes and promotes sustainability across various biological fields.  This research topic extends a warm invitation to authors, encouraging them to contribute to the unfolding narrative of ionic liquids in cellular science. It serves as a dynamic platform for showcasing the diverse dimensions of this impactful intersection.

Keywords: ionic liquids; cellular dynamics; multidisciplinary research; biophysical effects; biotechnological applications

We envision this special issue as a platform encompassing diverse themes associated with bioinspired Ionic Liquids (ILs) and Deep Eutectic Solvents (DES). We welcome a spectrum of contributions, including Original Research, Reviews, Mini Reviews, and Perspective articles on themes including, but not limited to:

1. Ionic Liquids in Cell Physiology: Cellular homeostasis and ionic liquid interactions, Influence of ionic liquids on cell membrane dynamics, Ionic liquid impact on cellular transport mechanisms.

2. Molecular Biology of Ionic Liquids: Gene expression modulation by ionic liquids, Epigenetic effects of ionic liquids on cellular processes, DNA and RNA interactions in the presence of ionic liquids.

3. Biophysical Effects of Ionic Liquids in Cells: Structural changes in cellular proteins induced by ionic liquids, Ionic liquid influence on cellular biomechanics, Interactions of ionic liquids with cellular organelles.

4. Ionic Liquids and Cellular Signaling: Intracellular signaling pathways affected by ionic liquids, Role of ionic liquids in cellular signal transduction, Impact on cell communication and response to stimuli.

5. Ionic Liquids in Cellular Metabolism: Metabolic pathways affected by ionic liquids, Mitochondrial function and ionic liquid exposure, Cellular energetics in the presence of ionic liquids.

6. Applications of Ionic Liquids in Biotechnology: Development of ionic liquid-based biosensors, Ionic liquid-assisted bioprocessing and fermentation, Biomedical applications of ionic liquids in drug delivery and therapy.

Dr. Gagandeep Singh
Dr. Meena Bisht
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• ionic liquids
• cellular dynamics
• multidisciplinary research
• biophysical effects
• biotechnological applications