Regulation of Fibroblasts and Fibrosis in Cardiovascular Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 20 August 2024 | Viewed by 74
Special Issue Editor
Interests: fibrosis; extracellular matrix; fibroblast activation; integrins; cardiovascular disease; alcohol abuse; decellularization; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The extracellular matrix forms a three-dimensional network of fibrous proteins and other biopolymers surrounding cells. Contrary to previous views, it is now appreciated that the extracellular matrix is highly dynamic, with alterations in composition and organization to meet the mechanical demands of tissues and organs. An increased deposition of the extracellular matrix is a common, transient response to tissue damage or stress in many organs. Dysregulation of the repair process can result in chronic increases in extracellular matrix or fibrosis. Accumulation of the extracellular matrix results in altered tissue biomechanical properties and can deleteriously impact tissue and organ function. In the cardiovascular system, fibrosis is a predictor of adverse cardiovascular events and is an important driving force in the progression of cardiovascular disease. Fibrosis is a highly complex process that involves a number of cell types, including extracellular matrix-producing cells, as well as immune and inflammatory cells. This process also involves an array of biochemical mediators, including secreted factors and diverse signaling pathways. Recent studies in experimental models and clinical observations indicate that fibrosis may be reversible. This has led to enhanced interest in elucidating the underlying mechanisms of fibrosis and identifying novel therapeutic targets for this process.
This Special Issue aims to provide review and primary research articles focused on the cellular and molecular mechanisms of cardiovascular fibrosis and potential therapeutic approaches for this processes.
We look forward to your contributions to this exciting Special Issue of Cells.
Prof. Dr. Wayne Carver
Guest Editor
Manuscript Submission Information
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Keywords
- fibrosis
- fibroblasts
- cardiovascular
- inflammation
- extracellular matrix
- collagen
