Special Issue "Sphingolipids: From Pathology to Therapeutic Perspectives - A Themed Honorary Issue to Prof. Lina Obeid"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 50869
Sphingolipids are ubiquitous components of cellular membranes. Following their discovery in the brain and first description in 1884 by J.L.W. Thudichum, sphingolipids were largely overlooked for almost a century, perhaps due to their complexity and enigmatic nature. It was with the discovery of sphingolipidoses, a series of autosomatically inherited diseases caused by mutations of enzymes involved in sphingolipid degradation, leading to their intralysosomal storage, that sphingolipids came back into the limelight. The essential breakthrough came, however, decades later in the 1990s with the discovery that sphingolipids are not just structural elements of cells but also intra- and extracellular signaling molecules. It turned out that not only their complex carbohydrate headgroups but especially their lipid backbones, including ceramide and sphingosine-1-phosphate (S1P), have selective physiological functions. Due to this new concept, sphingolipids emerged as essential players in many pathologies, including cancer, diabetes, neurodegenerative disorders, and autoimmune diseases. The aim of the present Special Issue is to highlight the function of sphingolipids starting from simple metabolic intermediates up to complex glycosphingolipids in diverse pathologies, with emphasis on the potential relevance of their metabolism for therapeutic strategies.
Prof. Dr. Gerhild van Echten-Deckert
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- sphingosine-1-phosphate (S1P)
- immune modulation