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Cells
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Emerging Topics in the Signaling Pathways of Angiogenesis
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Emerging Topics in the Signaling Pathways of Angiogenesis

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".

Deadline for manuscript submissions: closed (25 April 2023) | Viewed by 6428

Special Issue Editors

Prof. Dr. Jincai Luo

E-Mail Website
Guest Editor
Institute of Molecular Medicine, New Life Science Building, Room 234, Peking University, Beijing 100871, China
Interests: angiogenesis and lymphangiogenesis; vascular inflammation and thrombosis; cellular signaling; vesicle traffic and exocytosis; growth factors
Prof. Dr. Zhi-Cheng Jing

E-Mail Website1 Website2
Guest Editor
Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Interests: genetics; pulmonary vascular science; thrombosis
Prof. Dr. Xiao Yang

E-Mail Website
Guest Editor
National Center for Protein Sciences (Beijing), Beijing, China
Interests: signaling

Special Issue Information

Dear Colleagues,

As an important scientific domain, angiogenesis, the formation of new blood vessels, has gradually penetrated many areas of biology, physiology/pathophysiology, and medicine. Over the last decade, there has been continuous progress in our understanding of angiogenesis, which involves a multitude of complex signaling programs, in various aspects ranging from the mechanism underlying endothelial plasticity, the regulation of cellular metabolism during angiogenic processes, to the development of new therapeutic avenues. As such, we highly encourage researchers to submit the potential topics including, but not limited to: vascular development/genetics, angiogenesis in tissue homeostasis/repair and pathology (such as tumor pathogenesis, inflammation, etc.), and advanced technologies (such as stem cell bioengineering, organoid, etc.) in observing the angiogenesis process at spatiotemporal high resolution or manipulating the angiogenesis for therapeutic purposes.

Prof. Dr. Jincai Luo
Prof. Dr. Zhi-Cheng Jing
Prof. Dr. Xiao Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • angiogenesis;
  • signaling pathways;
  • vascular development;
  • tissue homeostasis and repair;
  • technological advances

Published Papers (3 papers)

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Research

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13 pages, 6143 KiB  
Article
Sema4C Is Required for Vascular and Primary Motor Neuronal Patterning in Zebrafish
by Jiajing Sheng, Boxuan Jiang, Ruijun Shi, Linsheng Shi and Dong Liu
Cells 2022, 11(16), 2527; https://doi.org/10.3390/cells11162527 - 15 Aug 2022
Cited by 1 | Viewed by 2082
Abstract
Endothelial cells (ECs) and neurons share a number of common signaling pathways and molecular mediators to orchestrate directional migration and guide the pattern of the vascular network and nervous system. So far, research concerning the functional coupling between vascular and neuronal pathfinding remains [...] Read more.
Endothelial cells (ECs) and neurons share a number of common signaling pathways and molecular mediators to orchestrate directional migration and guide the pattern of the vascular network and nervous system. So far, research concerning the functional coupling between vascular and neuronal pathfinding remains insufficient. Semaphorin4C (sema4C), a member of class 4 semaphorins, is initially described in the nervous system, whose role has been demonstrated in diverse biological developments. The present study focused on the role of sema4C in the vascular and neural development process in zebrafish embryos. It confirmed that sema4C is expressed in both the nervous system and intersegmental vessels (ISVs) in zebrafish embryos by diverse expression analysis. It also showed that the knockdown of sema4C caused a serious pathfinding anomaly both in the ISVs and primary motor neurons (PMNs) of zebrafish embryos. In addition, overexpressing exogenous sema4C mRNA in sema4C morphants remarkably neutralized the defective pattern of the vascular and neural system. Collectively, this report suggests that sema4C acts as a dual guiding factor regulating vascular and neuronal development. These findings elucidate a new molecular mechanism underlying blood vessel and nerve development and might serve as groundwork for future research on functional coupling between both systems. Full article
(This article belongs to the Special Issue Emerging Topics in the Signaling Pathways of Angiogenesis)
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Review

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23 pages, 2976 KiB  
Review
The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease
by Rong Mou, Kai Chen, Pengwei Zhu, Qingbo Xu and Liang Ma
Cells 2022, 11(24), 4056; https://doi.org/10.3390/cells11244056 - 15 Dec 2022
Viewed by 2086
Abstract
Lymphatic vessels, as the main tube network of fluid drainage and leukocyte transfer, are responsible for the maintenance of homeostasis and pathological repairment. Recently, by using genetic lineage tracing and single-cell RNA sequencing techniques, significant cognitive progress has been made about the impact [...] Read more.
Lymphatic vessels, as the main tube network of fluid drainage and leukocyte transfer, are responsible for the maintenance of homeostasis and pathological repairment. Recently, by using genetic lineage tracing and single-cell RNA sequencing techniques, significant cognitive progress has been made about the impact of stem/progenitor cells during lymphangiogenesis. In the embryonic stage, the lymphatic network is primarily formed through self-proliferation and polarized-sprouting from the lymph sacs. However, the assembly of lymphatic stem/progenitor cells also guarantees the sustained growth of lymphvasculogenesis to obtain the entire function. In addition, there are abundant sources of stem/progenitor cells in postnatal tissues, including circulating progenitors, mesenchymal stem cells, and adipose tissue stem cells, which can directly differentiate into lymphatic endothelial cells and participate in lymphangiogenesis. Specifically, recent reports indicated a novel function of lymphangiogenesis in transplant arteriosclerosis and atherosclerosis. In the present review, we summarized the latest evidence about the diversity and incorporation of stem/progenitor cells in lymphatic vasculature during both the embryonic and postnatal stages, with emphasis on the impact of lymphangiogenesis in the development of vascular diseases to provide a rational guidance for future research. Full article
(This article belongs to the Special Issue Emerging Topics in the Signaling Pathways of Angiogenesis)
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Other

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18 pages, 1357 KiB  
Systematic Review
Parsimonious Effect of Pentoxifylline on Angiogenesis: A Novel Pentoxifylline-Biased Adenosine G Protein-Coupled Receptor Signaling Platform
by William Khoury, Ryan Trus, Xingyu Chen, Leili Baghaie, Mira Clark, Myron R. Szewczuk and Mohammad El-Diasty
Cells 2023, 12(8), 1199; https://doi.org/10.3390/cells12081199 - 20 Apr 2023
Cited by 1 | Viewed by 1877
Abstract
Angiogenesis is the physiological process of developing new blood vessels to facilitate the delivery of oxygen and nutrients to meet the functional demands of growing tissues. It also plays a vital role in the development of neoplastic disorders. Pentoxifylline (PTX) is a vasoactive [...] Read more.
Angiogenesis is the physiological process of developing new blood vessels to facilitate the delivery of oxygen and nutrients to meet the functional demands of growing tissues. It also plays a vital role in the development of neoplastic disorders. Pentoxifylline (PTX) is a vasoactive synthetic methyl xanthine derivative used for decades to manage chronic occlusive vascular disorders. Recently, it has been proposed that PTX might have an inhibitory effect on the angiogenesis process. Here, we reviewed the modulatory effects of PTX on angiogenesis and its potential benefits in the clinical setting. Twenty-two studies met the inclusion and exclusion criteria. While sixteen studies demonstrated that pentoxifylline had an antiangiogenic effect, four suggested it had a proangiogenic effect, and two other studies showed it did not affect angiogenesis. All studies were either in vivo animal studies or in vitro animal and human cell models. Our findings suggest that pentoxifylline may affect the angiogenic process in experimental models. However, there is insufficient evidence to establish its role as an anti-angiogenesis agent in the clinical setting. These gaps in our knowledge regarding how pentoxifylline is implicated in host-biased metabolically taxing angiogenic switch may be via its adenosine A2BAR G protein-coupled receptor (GPCR) mechanism. GPCR receptors reinforce the importance of research to understand the mechanistic action of these drugs on the body as promising metabolic candidates. The specific mechanisms and details of the effects of pentoxifylline on host metabolism and energy homeostasis remain to be elucidated. Full article
(This article belongs to the Special Issue Emerging Topics in the Signaling Pathways of Angiogenesis)
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