New Insights Into Comprehensive Molecular Systems Regulating Cell Proliferation, Growth, and Cell Death

Dear Colleagues,

This Special Issue focuses on basic cellular events (“proliferation”, “growth”, and “death”) in the process of organ regeneration. If the organ is damaged and loses its function, it will immediately begin to regenerate and try to withhold its function. The regeneration process is complicated and unique depending on the organ, and therefore not yet fully elucidated.

In each organ, regeneration is achieved by smart and unique molecular machinery that coordinates cell proliferation, growth, and death. The proliferation of parenchymal/non-parenchymal cells is a central event of regeneration. Various kinds of pathological and mechanical stresses, such as ischemia–reperfusion or surgical resection, ignite the unique machinery by comprehensively regulating the initiation, continuation, and termination of regeneration. Similarly, cell growth plays a pivotal role in the achievement of quick and sure organ regeneration, especially in cases where cell proliferation is disturbed. The signals that regulate cell proliferation and growth interact each other to advance regeneration without delay. It is also important in all processes relating to regeneration to regulate cell death (programmed cell death or not). The signals of cell proliferation, growth, and survival are activated in the early regeneration phase, and often involved in the protection of cell death. Programmed cell death may play a key role to settle or terminate regeneration when sufficient function is recovered. At present, the precise mechanism of the cellular events mentioned above are not fully understood.

In this Special Issue, we expect papers on the molecular mechanisms that comprehensively regulate the interactions of cell proliferation, growth, survival, and death in organ regeneration in common or pathological situations. Studies on the molecular/cellular therapy of various diseases, surgical resection, and organ transplantation are also welcome.

Prof. Dr. Michitaka Ozaki
Guest Editor

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• regeneration
• ischemia–reperfusion (hypoxia–reoxygenation) injury
• surgical resection
• cell proliferation
• cell growth
• programmed cell death
• oxidative stress
• signal transduction