The New World of Mitosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 482
Special Issue Editor
Special Issue Information
Dear Colleagues,
The fundamental attribute of life is an extraordinary capacity to grow, reproduce, and, in the long term, to evolve. This ability relies on the mechanism of cell division, or mitosis. The phenomenon of mitosis has fascinated biologists since the first observations of pioneers until the present times. Mitosis must be tightly controlled to ensure an exact partitioning of the chromosomes at each cell division. Cells pack their DNA genome into chromosomes such that they can be replicated and accurately segregated into newly formed daughter cells. Any errors lead to an abnormal number of chromosomes, a situation that favors cancer emergence or genetic abnormalities in the cell progeny. Therefore, the mechanism of chromosome organization and segregation is a key problem in both biology and medicine. Today, new technologies and concepts integrating diverse fields are being applied to mitosis research. In this Special Issue of Cells, we propose to gather reviews and original papers that bring new insights into the macromolecular structures driving mitosis (centromeres, centrosomes, kinetochore fibers, and so on) and the biophysical mechanisms leading to the accurate organization and spatial orientation of the mitotic spindle.
Dr. Alain Debec
Guest Editor
Manuscript Submission Information
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Keywords
- mitotic spindle
- centrosome
- centromere
- kinetochore fibers
- chromosome
- spindle orientation
- microtubules dynamics
