Molecular Mechanism of Protein Synthesis in Alzheimer's Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 180
Special Issue Editor
Special Issue Information
Dear Colleagues,
Local protein synthesis at synapses plays a crucial role in synaptic plasticity and might contribute to memory loss. Furthermore, a morphological feature of abnormal translational machinery, observed in Alzheimer’s disease mice models and patients, is the degeneration of dendritic spines. Recent studies have demonstrated how mRNA expression locally at synapses and the control of their expression, the mRNA expression of several ribosomal proteins, the expression of selected histones involved in nucleolar processing, and the expression levels of initiation and elongation factors of protein synthesis in the CA1 region as well as dentate gyrus of the hippocampus are observed in individuals with AD. Moreover, ER stress and the UPR system are also found to be altered in Alzheimer’s disease mice models and patients.
This Special Issue aims to collect all of the literature present in the field and provide a great contribution to the scientific community. Alzheimer’s disease is a very multifactorial disease, and identifying the molecular mechanism underlining its complex pathology will be helpful for the entire community.
The idea of this Special Issue is focused on the collection of all information and methodologies related to protein synthesis machinery and cognition.
Dr. Antonella Borreca
Guest Editor
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Keywords
- protein synthesis
- UPR system
- ER stress
- translational factor and cognition
- Alzheimer’s disease
- translational control
- post-translational modification
