Signaling Pathways for Nervous System Mechanotransduction
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 129
Special Issue Editor
Special Issue Information
Dear Colleagues,
The idea that cells can interpret and reply to mechanical cues is not new to the scientific community. However, the elucidation of the molecular mechanisms by which the cell observes and transforms the mechanics of the extracellular matrix has become the subject of intense study. Mechanotransduction is the process of translating mechanical stress on cells into chemical signals that trigger adaptive responses. Important physiological reactions, such as vasodilation, hearing, balance, muscular contraction, and touch, are influenced by mechanotransduction. Following mild traumatic brain injury (TBI), primary mechanical damage to the brain tissue develops into secondary injury cascades that prolong and exacerbate the injury. In particular, neurons are vulnerable to excitotoxicity, axonal injury, and the subsequent activation of cell death pathways. Alternately, after mechanical injury, astrocytes and other glial cells enter an activated state. Mechanotransduction involves broad, yet critical cellular signaling processes which have yet to be elucidated in traumatic brain injury (TBI) pathophysiology. Therefore, it is necessary to develop strategies for studying the mechanics of cellular injury and the associated mechanobiological responses that result from well-defined mechanical perturbation.
This Special Issue aims to provide a comprehensive overview of in vitro and in vivo models that have been used to shed light on the important cellular, molecular, and mechanobiological aspects of mild traumatic brain injury. We hope that the approaches presented provide valuable practical support to the community of researchers investigating mechanotransduction in the central nervous system.
Dr. Pamela J. VandeVord
Guest Editor
Manuscript Submission Information
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Keywords
- mechanotransduction
- neurotrauma
- cell death
- inflammation
- reactivity
- regeneration
