Special Issue "Signaling Pathways for Nervous System Mechanotransduction"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 92

Special Issue Editor

Virginia Polytechnic Institute, State University, Blacksburg, VA, USA
Interests: neurotrauma; bioengineering; injury biomechanics; neuroprotection; glia; neuroinflammation

Special Issue Information

Dear Colleagues,

The idea that cells can interpret and reply to mechanical cues is not new to the scientific community. However, the elucidation of the molecular mechanisms by which the cell observes and transforms the mechanics of the extracellular matrix has become the subject of intense study. Mechanotransduction is the process of translating mechanical stress on cells into chemical signals that trigger adaptive responses. Important physiological reactions, such as vasodilation, hearing, balance, muscular contraction, and touch, are influenced by mechanotransduction. Following mild traumatic brain injury (TBI), primary mechanical damage to the brain tissue develops into secondary injury cascades that prolong and exacerbate the injury. In particular, neurons are vulnerable to excitotoxicity, axonal injury, and the subsequent activation of cell death pathways. Alternately, after mechanical injury, astrocytes and other glial cells enter an activated state. Mechanotransduction involves broad, yet critical cellular signaling processes which have yet to be elucidated in traumatic brain injury (TBI) pathophysiology. Therefore, it is necessary to develop strategies for studying the mechanics of cellular injury and the associated mechanobiological responses that result from well-defined mechanical perturbation.

This Special Issue aims to provide a comprehensive overview of in vitro and in vivo models that have been used to shed light on the important cellular, molecular, and mechanobiological aspects of mild traumatic brain injury. We hope that the approaches presented provide valuable practical support to the community of researchers investigating mechanotransduction in the central nervous system.

Dr. Pamela J. VandeVord
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mechanotransduction
  • neurotrauma
  • cell death
  • inflammation
  • reactivity
  • regeneration

Published Papers

There is no accepted submissions to this special issue at this moment.
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