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Cells
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Lipids, Their Receptors and Signaling in Development and Diseases
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Lipids, Their Receptors and Signaling in Development and Diseases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 3877

Special Issue Editor

Dr. Laurent Calvier

E-Mail Website
Guest Editor
Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas, TX, USA
Interests: hypertension; heart failure; chronic inflammatory diseases; lipids; biomarkers

Special Issue Information

Dear Colleagues,

This Special Issue entitled "Lipids, Their Receptors and Signaling in Development and Diseases" aims to shed light on the latest advancements in the field of lipid signaling, including their receptors as well as their implications in various aspects of development and disease. Lipids play crucial roles as signaling molecules, influencing cellular processes and contributing to the pathogenesis of numerous disorders. This Special Issue seeks to provide a comprehensive overview of recent research in the field, encompassing both fundamental discoveries and potential therapeutic applications.

Key Topics include basic research on the role of lipids, receptors, and signaling in:

  • Cellular development and differentiation;
  • Inflammation and immune response;
  • Cancer progression and therapy;
  • Neurodevelopmental disorders;
  • Metabolism and metabolic diseases;
  • Cardiovascular diseases.

This Special Issue also covers therapeutic and technological advancements in:

  • Lipids as therapeutic targets for drug development;
  • Lipids-based drug delivery systems and nanomedicine;
  • Lipidomics: Analytical methods and technological advancements;
  • Emerging trends and future directions in lipid signaling research.

This Special issue Invites contributions that delve into the synthesis, characterization, and functional roles of lipids, highlighting their significance in understanding disease mechanisms and exploring potential therapeutic interventions. By addressing these cutting-edge topics, this Special Issue aims to inspire new research directions and promote advancements in the field of lipid signaling.

Dr. Laurent Calvier
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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17 pages, 14949 KiB  
Article
Safety of Anti-Reelin Therapeutic Approaches for Chronic Inflammatory Diseases
by Laurent Calvier, Anna Alexander, Austin T. Marckx, Maria Z. Kounnas, Murat Durakoglugil and Joachim Herz
Cells 2024, 13(7), 583; https://doi.org/10.3390/cells13070583 - 27 Mar 2024
Viewed by 943
Abstract
Reelin, a large extracellular glycoprotein, plays critical roles in neuronal development and synaptic plasticity in the central nervous system (CNS). Recent studies have revealed non-neuronal functions of plasma Reelin in inflammation by promoting endothelial–leukocyte adhesion through its canonical pathway in endothelial cells (via [...] Read more.
Reelin, a large extracellular glycoprotein, plays critical roles in neuronal development and synaptic plasticity in the central nervous system (CNS). Recent studies have revealed non-neuronal functions of plasma Reelin in inflammation by promoting endothelial–leukocyte adhesion through its canonical pathway in endothelial cells (via ApoER2 acting on NF-κB), as well as in vascular tone regulation and thrombosis. In this study, we have investigated the safety and efficacy of selectively depleting plasma Reelin as a potential therapeutic strategy for chronic inflammatory diseases. We found that Reelin expression remains stable throughout adulthood and that peripheral anti-Reelin antibody treatment with CR-50 efficiently depletes plasma Reelin without affecting its levels or functionality within the CNS. Notably, this approach preserves essential neuronal functions and synaptic plasticity. Furthermore, in mice induced with experimental autoimmune encephalomyelitis (EAE), selective modulation of endothelial responses by anti-Reelin antibodies reduces pathological leukocyte infiltration without completely abolishing diapedesis. Finally, long-term Reelin depletion under metabolic stress induced by a Western diet did not negatively impact the heart, kidney, or liver, suggesting a favorable safety profile. These findings underscore the promising role of peripheral anti-Reelin therapeutic strategies for autoimmune diseases and conditions where endothelial function is compromised, offering a novel approach that may avoid the immunosuppressive side effects associated with conventional anti-inflammatory therapies. Full article
(This article belongs to the Special Issue Lipids, Their Receptors and Signaling in Development and Diseases)
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13 pages, 6527 KiB  
Communication
Effect of LDL Extracted from Human Plasma on Membrane Stiffness in Living Endothelial Cells and Macrophages via Scanning Ion Conductance Microscopy
by Diana Kiseleva, Vasilii Kolmogorov, Vadim Cherednichenko, Ulyana Khovantseva, Anastasia Bogatyreva, Yuliya Markina, Petr Gorelkin, Alexander Erofeev and Alexander Markin
Cells 2024, 13(4), 358; https://doi.org/10.3390/cells13040358 - 18 Feb 2024
Viewed by 938
Abstract
Mechanical properties of living cells play a crucial role in a wide range of biological functions and pathologies, including atherosclerosis. We used low-stress Scanning Ion-Conductance Microscopy (SICM) correlated with confocal imaging and demonstrated the topographical changes and mechanical properties alterations in EA.hy926 and [...] Read more.
Mechanical properties of living cells play a crucial role in a wide range of biological functions and pathologies, including atherosclerosis. We used low-stress Scanning Ion-Conductance Microscopy (SICM) correlated with confocal imaging and demonstrated the topographical changes and mechanical properties alterations in EA.hy926 and THP-1 exposed to LDL extracted from CVD patients’ blood samples. We show that the cells stiffened in the presence of LDL, which also triggered caveolae formation. Endothelial cells accumulated less cholesterol in the form of lipid droplets in comparison to THP-1 cells based on fluorescence intensity data and biochemical analysis; however, the effect on Young’s modulus is higher. The cell stiffness is closely connected to the distribution of lipid droplets along the z-axis. In conclusion, we show that the sensitivity of endothelial cells to LDL is higher compared to that of THP-1, triggering changes in the cytoskeleton and membrane stiffness which may result in the increased permeability of the intima layer due to loss of intercellular connections and adhesion. Full article
(This article belongs to the Special Issue Lipids, Their Receptors and Signaling in Development and Diseases)
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Review

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18 pages, 1725 KiB  
Review
AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors
by Leonida Rakateli, Rosanna Huchzermeier and Emiel P. C. van der Vorst
Cells 2023, 12(23), 2752; https://doi.org/10.3390/cells12232752 - 30 Nov 2023
Cited by 4 | Viewed by 1710
Abstract
Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors. However, recent studies have highlighted that xenobiotic receptors also play a key role in the regulation of lipid [...] Read more.
Traditionally, xenobiotic receptors are known for their role in chemical sensing and detoxification, as receptor activation regulates the expression of various key enzymes and receptors. However, recent studies have highlighted that xenobiotic receptors also play a key role in the regulation of lipid metabolism and therefore function also as metabolic sensors. Since dyslipidemia is a major risk factor for various cardiometabolic diseases, like atherosclerosis and non-alcoholic fatty liver disease, it is of major importance to understand the molecular mechanisms that are regulated by xenobiotic receptors. In this review, three major xenobiotic receptors will be discussed, being the aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). Specifically, this review will focus on recent insights into the metabolic functions of these receptors, especially in the field of lipid metabolism and the associated dyslipidemia. Full article
(This article belongs to the Special Issue Lipids, Their Receptors and Signaling in Development and Diseases)
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