Cellular Stress and Regulation of Cell Growth and Apoptosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 320
Special Issue Editors
Interests: cancer; cell cycle; cellular senescence; endoplasmic reticulum stress; molecular target drugs; p53; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; cell cycle; cellular senescence; endoplasmic reticulum stress; molecular target drugs; p53; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Mammalian cells have the ability to adapt to various cellular situatons. Over 30 years of research in cell biology has provided considerable insight into the molecular mechanisms by which individual cells respond to homeostatic perturbations. For example, the integrated stress response (ISR) is a fine-tuning signal transduction pathway that exists in mammalian cells that is activated by cells to adapt to a variety of stresses, including hypoxia, amino acid deprivation, virus infection and endoplasmic reticlum (ER) stress, which is caused by the accumulation of unfolded or misfolded proteins in the ER. Although ISR is primarily a pro-survival homeostasis program designed to adapt cells to varous stresses, exposure to severe stress on cells rather induces signal transduction to apoptotic cell death. The existence of transcriptional factors (e.g., ATF4, c-Myc and p53) involved in cell fate decisions such as cell survival and death has been elucidated, and this impairment in signaling transduction is involved in the development and progression of various diseases, including neurodegenerative diseases, diabetes and cancers. This Special Issue provides an open access forum aimed at compiling a collection of original research and review articles on the response to expanding cellular stress and cell fate decisions.
Prof. Hidetoshi Hayashi
Dr. Yasumichi Inoue
Guest Editors
Manuscript Submission Information
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Keywords
- apoptosis
- cancer
- cell cycle
- DNA damage
- endoplasmic reticlum (ER) stress
- hypoxia
- integrated stress response (ISR)
- metabolic diseases
- oxidative stress
- senescence
- therapeutic approach
