Cell Asymmetry and Polarity: Guiding Cellular Behavior and Development
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (19 April 2024) | Viewed by 208
Special Issue Editor
Interests: planar cell polarity; protein–protein interaction; neural tube closure; ubiquitination; cancer biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cell asymmetry, an essential aspect of cell biology, directs cellular behavior and organizes complex developmental processes. Interlinked with cell polarity, it governs cell differentiation, tissue formation, and organogenesis, underscoring its fundamental role in health and disease.
New insights have highlighted the pivotal role of cell asymmetry in diseases, such as cancer, and developmental disorders, illuminating its potential in therapeutic strategies. Simultaneously, our understanding of the biomechanical aspects of cell asymmetry has grown, revealing compelling nuances of tissue morphogenesis.
Our comprehension of cell asymmetry at the molecular level has also broadened, unveiling the integral role of proteins in the planar cell polarity (PCP) pathway, which is responsible for the two-dimensional cell orientation, the apical and basolateral polarity, the left–right axis formation (Nodal-Lefty-Pitx2 module), and neuronal polarization. These proteins exert directional control on cells, thereby shaping tissue architecture. Furthermore, their cross-talk with other signaling pathways, including Wnt, TGF-β, and Notch, intricately modulates cell behavior and tissue organization.
In this Special Issue, we aim to gather the latest discoveries in cell asymmetry and polarity, with an emphasis on its molecular underpinnings, impact on cell behavior as well as development, associations with diseases, and potential therapeutic implications. We invite original research and review articles that deepen our understanding of this dynamic and critical field.
You may choose our Joint Special Issue in Life.
Dr. Tadahiro Nagaoka
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell asymmetry
- cell polarity
- tissue morphogenesis
- planar cell polarity (PCP) pathway
- wnt pathway
- therapeutic implications
