Focus on Redox Signaling
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 30 August 2024 | Viewed by 257
Special Issue Editor
Interests: redox proteomics; oxidation; redox signaling; redox regulation; lipid peroxidation; oxidative stress biomarkers; GSH; inflammatory biomarkers; cell culture; GPxs; reactive oxygen species
Special Issue Information
Dear Colleagues,
The study of redox signaling is a rapidly evolving field with important implications for both basic science and clinical medicine. Indeed, reactive molecules do not always lead to pathological conditions, but it is largely acknowledged that reactive oxygen species (ROS) play a crucial role in many physiological processes.
Redox signaling refers to the molecular mechanisms by which cells use ROS and other reactive molecules to regulate a wide range of cell functions. This signaling is a transduction pathway that is carried out by electron transfer reactions and involves radical molecules, reducing equivalents, and redox-active metals.
It is important to consider that redox signaling is different from other types of cell signaling because molecules that have a high non-specific reaction potential are involved and they could be damaging to the cell itself. Therefore, the balance between oxidants and nucleophiles is an essential requirement for human health. Indeed, an excessive accumulation of ROS leads to oxidative stress and an altered redox state, resulting in damage to biological molecules such as proteins, lipids, and DNA. Thus, it is involved in several diseases such as atherosclerosis, type 2 diabetes, cancer, aging, and neurodegeneration.
For all these reasons, research in this area has focused on understanding how ROS are generated and regulated within cells, as well as on developing new methods for detecting and manipulating redox signaling pathways.
This Special Issue aims to provide an overview of recent research into cellular redox balance as well as the identification of the main players in redox signaling.
Dr. Valentina Bosello-Travain
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- redox signaling
- oxidative stress
- reactive oxygen species (ROS)
- reactive molecules
- cellular signaling
- human diseases
