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Cells
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Molecular Mechanisms of Drug Addiction Treatment
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Molecular Mechanisms of Drug Addiction Treatment

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 1491

Special Issue Editors

Dr. Shiqiu Meng

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Guest Editor
National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China
Interests: neurological mechanism and interventions of drug addiction and other related mental diseases
Prof. Dr. Tifei Yuan

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Guest Editor
Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China
Interests: neuromodulation; drug addiction
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yingjie Zhu

E-Mail Website
Guest Editor
1. Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
2. Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Fundamental Research Institutions, Shenzhen, China
Interests: the role of synaptic plasticity in drug addiction; the neural circuit mechanism in drug addiction
Dr. Jie Yan

E-Mail Website
Guest Editor
Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, China
Interests: neural injury and addiction of new psychoactive substances

Special Issue Information

Dear Colleagues, 

Drug addiction has been a major public health problem and a chronic brain disease, creating a heavy burden on patients, families and the society around the world. In recent years, animal and clinical research on treatments of drug addiction has flourished, including pharmaceutical therapies, as well as behavioral and neuromodulating interventions. Many breakthroughs have been made in revealing the underlying molecular mechanisms of these treatments. The aim of this Special Issue is to address traditional and state-of-the-art approaches to the treatment of drug addiction and their molecular bases, and give voice to the existing bottleneck problems and future research directions in this field. This Special Issue, welcome (but is not strictly limited to) original research and review papers that discuss new developments in genetic, molecular, and cellular mechanisms of pharmaceutical and non-pharmaceutical interventions of drug addiction and its neurotoxicity, based on established or novel animal models and human subjects.

Dr. Shiqiu Meng
Prof. Dr. Tifei Yuan
Prof. Dr. Yingjie Zhu
Dr. Jie Yan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • addiction
  • relapse
  • synaptic plasticity
  • genetic
  • neuroimaging
  • neural circuit
  • intervention
  • pharmacotherapy
  • neurotoxicity

Published Papers (1 paper)

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Research

15 pages, 3470 KiB  
Article
The Role of circTmeff-1 in Morphine Addiction Memory of Mice
by Hailei Yu, Boyang Wen, Yun Lu, Bing Xie, Feng Yu, Minglong Zhang, Chunling Ma, Bin Cong, Di Wen and Haitao Bi
Cells 2023, 12(15), 1985; https://doi.org/10.3390/cells12151985 - 1 Aug 2023
Viewed by 1057
Abstract
In addition to the essential pharmacological effects of opioids, situational cues associated with drug addiction memory are key triggers for drug seeking. CircRNAs, an emerging hotspot regulator in crown genetics, play an important role in central nervous system-related diseases. However, the internal mediating [...] Read more.
In addition to the essential pharmacological effects of opioids, situational cues associated with drug addiction memory are key triggers for drug seeking. CircRNAs, an emerging hotspot regulator in crown genetics, play an important role in central nervous system-related diseases. However, the internal mediating mechanism of circRNAs in the field of drug reward and addiction memory remains unknown. Here, we trained mice on a conditional place preference (CPP) model and collected nucleus accumbens (NAc) tissues from day 1 (T0) and day 8 (T1) for high-throughput RNA sequencing. QRT-PCR analysis revealed that circTmeff-1 was highly expressed in the NAc core but not in the NAc shell, suggesting that it plays a role in addiction memory formation. Meanwhile, the down-regulation of circTmeff-1 by adeno-associated viruses in the NAc core or shell could inhibit the morphine CPP scores. Subsequently, the GO and KEGG analyses indicated that circTmeff-1 might regulate the addiction memory via the MAPK and AMPK pathways. These findings suggest that circTmeff-1 in NAc plays a crucial role in morphine-dependent memory formation. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Drug Addiction Treatment)
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