Platelet Biology and Functions

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 1423

Special Issue Editor


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Guest Editor
Academia Nacional de Medicina de Buenos Aires, Buenos Aires, Argentina
Interests: platelets; megakaryocytes; infection; platelets-leukocyte interactions

Special Issue Information

Dear Colleagues,

Platelets are small anucleated cytoplasmic fragments derived from large megakaryocytes present in the bone marrow and are involved not only in hemostasis and arterial thrombosis but also in other physiological and pathophysiological processes.

Considerable evidence to date has underscored the ability of platelets to function as pluripotent cells, understanding the many molecular mediators critical to platelet function. This all indicates that platelets impact a wide range of diseases including cardiovascular, obesity, metabolic syndrome, and gastrointestinal disorders as well as infection, cancer, neurodegeneration, and other brain dysfunctions. 

To better understand the mechanisms by which platelets protect or damage an organism, the latest research on platelet biogenesis, activation, function, and clearance in health and disease must be integrated.

This Special Issue entitled "Platelet Biology and Functions" will focus on the latest description of the more interesting aspects of platelet biology that are highly relevant to human physiopathology.

Dr. Mirta A. Schattner
Guest Editor

Manuscript Submission Information

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Keywords

  • platelets
  • virus
  • toll-like receptors
  • microvesicles

Published Papers (1 paper)

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Research

26 pages, 6636 KiB  
Article
Changes in the Proteome of Platelets from Patients with Critical Progression of COVID-19
by Monika Wolny, Svitlana Rozanova, Cornelius Knabbe, Kathy Pfeiffer, Katalin Barkovits, Katrin Marcus and Ingvild Birschmann
Cells 2023, 12(17), 2191; https://doi.org/10.3390/cells12172191 - 1 Sep 2023
Cited by 2 | Viewed by 1237
Abstract
Platelets, the smallest cells in human blood, known for their role in primary hemostasis, are also able to interact with pathogens and play a crucial role in the immune response. In severe coronavirus disease 2019 (COVID-19) cases, platelets become overactivated, resulting in the [...] Read more.
Platelets, the smallest cells in human blood, known for their role in primary hemostasis, are also able to interact with pathogens and play a crucial role in the immune response. In severe coronavirus disease 2019 (COVID-19) cases, platelets become overactivated, resulting in the release of granules, exacerbating inflammation and contributing to the cytokine storm. This study aims to further elucidate the role of platelets in COVID-19 progression and to identify predictive biomarkers for disease outcomes. A comparative proteome analysis of highly purified platelets from critically diseased COVID-19 patients with different outcomes (survivors and non-survivors) and age- and sex-matched controls was performed. Platelets from critically diseased COVID-19 patients exhibited significant changes in the levels of proteins associated with protein folding. In addition, a number of proteins with isomerase activity were found to be more highly abundant in patient samples, apparently exerting an influence on platelet activity via the non-genomic properties of the glucocorticoid receptor (GR) and the nuclear factor κ-light-chain-enhancer of activated B cells (NFκB). Moreover, carbonic anhydrase 1 (CA-1) was found to be a candidate biomarker in platelets, showing a significant increase in COVID-19 patients. Full article
(This article belongs to the Special Issue Platelet Biology and Functions)
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