The Complex and Multifaceted Role of Damage Associated Molecular Patterns (DAMPs) in COPD
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 20 May 2024 | Viewed by 96
Special Issue Editor
Interests: COPD; DAMPs; innate immune system; cigarette smoke; biomarkers; cell death; RAGE
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic obstructive pulmonary disease (COPD) is a severe and debilitating respiratory disease characterized by chronic bronchitis and emphysema. Currently, no curative treatments are available for COPD; instead, all treatments are focused on reducing symptoms and improving the quality of life. In order to facilitate the development of novel treatments, it is important to fully understand the pathophysiology of COPD. Over the past 10 years, increasing amounts of evidence have become available that show that endogenous danger signals, called damage-associated molecular patterns (DAMPs), and their receptors play an instrumental role in various aspects of the pathophysiology of COPD.
There is a growing list of molecules that can act as DAMPs, but they all have two things in common: (1) they are released into the extracellular space upon cellular damage and cell death, and (2) they can trigger a pro-inflammatory response by activation of pattern recognition receptors (PRRs). DAMPs can be derived from various sub-cellular origins, like the mitochondrion, the cytoplasm, the nucleus, the cytoskeleton or even the extracellular matrix. Furthermore, DAMPs can bind to and activate a plethora of PRRs, including Toll-like receptors (TLRs), the receptor for advanced glycation end-products (RAGE) or purinergic receptors.
The goal of this Special Issue is to gather evidence for the various roles of DAMPs and their receptors in the pathophysiology of COPD. Which DAMPs are associated with emphysema, or chronic bronchitis? Which DAMPs are related to the development of exacerbations? Does the remodeled and damaged extracellular matrix in COPD patients lead to the increased release of ECM-DAMPs? And can we use specific inhibitors for DAMPs or their receptors as treatment for COPD patients? These are all questions that could be addressed in this Special Issue of Cells.
Dr. Simon D. Pouwels
Guest Editor
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Keywords
- COPD
- DAMPs
- danger signals
- cell death
- pattern recognition receptors
- RAGE
- HMGB1
- necroptosis
- biomarkers
- toll-like receptors
