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Brain Sciences
Special Issues
Transcranial Magnetic Stimulation: New Research
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Transcranial Magnetic Stimulation: New Research

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 3931

Special Issue Editors

Dr. Chiara Negwer

E-Mail Website
Guest Editor
TUM Fakultät für Medizin, Munich, Germany
Interests: craniotomy; language lateralization; transcranial magnetic stimulation
Dr. Sebastian Ille

E-Mail Website
Guest Editor
Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
Interests: awake craniotomy; brain mapping; glioma; intraoperative imaging; intraoperative neuromonitoring; robotics; spinal navigation; spinal instrumentation; transcranial magnetic stimulation

Special Issue Information

Dear Colleagues,

In the past few years, the relevance of non-invasive brain mapping techniques has increased in different neuroscientific fields and the impact of transcranial magnetic stimulation in this field has led to a multitude of publications in various areas. Transcranial magnetic stimulation is used in clinical setup and experimental research to investigate motor and speech function, as well as other higher cognitive functions such as calculation function, spatial working memory and cognition. Furthermore, publications using TMS on patients and healthy volunteers have provided insights into cortical language distribution and shown cortical reorganization and neuroplasticity, combining TMS with other neuroimaging techniques (e.g., fMRI, DTI). The neuromodulating character of TMS is also used in the neurorehabilitation of stroke and brain tumor patients, delivering promising results.

The objective of this Special Issue is to investigate the newest advancements of TMS mapping techniques in various neuroscientific fields. Authors are encouraged to submit their work in the form of original research, review articles, and case reports, covering multimodal approaches, technical advances and particularly offline stimulation protocols in patients and healthy volunteers.

Dr. Chiara Negwer
Dr. Sebastian Ille
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain mapping
  • cortical mapping
  • DTI fibertracking
  • glioma
  • transcranial magnetic stimulation
  • neuroimaging
  • neuronavigation
  • neuroplasticity
  • neurorehabilitation

Published Papers (2 papers)

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Research

16 pages, 2168 KiB  
Article
Cortical Location of Language Function May Differ between Languages While White Matter Pathways Are Similar in Brain Lesion Patients
by Corinna Boerner, Axel Schroeder, Bernhard Meyer, Sandro M. Krieg and Sebastian Ille
Brain Sci. 2023, 13(8), 1141; https://doi.org/10.3390/brainsci13081141 - 29 Jul 2023
Viewed by 764
Abstract
The neural representation of language can be identified cortically using navigated repetitive transcranial magnetic stimulation and subcortically using the fiber tracking of diffusion tensor imaging. We investigated how cortical locations of language and language-eloquent white matter pathways differ in 40 brain lesion patients [...] Read more.
The neural representation of language can be identified cortically using navigated repetitive transcranial magnetic stimulation and subcortically using the fiber tracking of diffusion tensor imaging. We investigated how cortical locations of language and language-eloquent white matter pathways differ in 40 brain lesion patients speaking various languages. Error rates related to stimulations at single sites in the frontal and parietal lobe differed significantly between Balto-Slavic and Indo-European languages. Error rates related to stimulations at single sites in the temporal lobe differed significantly between bilingual individuals. No differences were found in the white matter language pathway volumes between Balto-Slavic and Indo-European languages nor between bilingual patients. These original and exploratory data indicate that the underlying subcortical structure might be similar across languages, with initially observed differences in the cortical location of language depending on the semantic processing, but these could not be confirmed using detailed statistical analyses pointing at a similar cortical and subcortical network. Full article
(This article belongs to the Special Issue Transcranial Magnetic Stimulation: New Research)
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19 pages, 1122 KiB  
Article
Upper Limb Function Recovery by Combined Repetitive Transcranial Magnetic Stimulation and Occupational Therapy in Patients with Chronic Stroke According to Paralysis Severity
by Daigo Sakamoto, Toyohiro Hamaguchi, Kai Murata, Hiroshi Ito, Yasuhide Nakayama and Masahiro Abo
Brain Sci. 2023, 13(2), 284; https://doi.org/10.3390/brainsci13020284 - 08 Feb 2023
Cited by 3 | Viewed by 2541
Abstract
Repetitive transcranial magnetic stimulation (rTMS) with intensive occupational therapy improves upper limb motor paralysis and activities of daily living after stroke; however, the degree of improvement according to paralysis severity remains unverified. Target activities of daily living using upper limb functions can be [...] Read more.
Repetitive transcranial magnetic stimulation (rTMS) with intensive occupational therapy improves upper limb motor paralysis and activities of daily living after stroke; however, the degree of improvement according to paralysis severity remains unverified. Target activities of daily living using upper limb functions can be established by predicting the amount of change after treatment for each paralysis severity level to further aid practice planning. We estimated post-treatment score changes for each severity level of motor paralysis (no, poor, limited, notable, and full), stratified according to Action Research Arm Test (ARAT) scores before combined rTMS and intensive occupational therapy. Motor paralysis severity was the fixed factor for the analysis of covariance; the delta (post-pre) of the scores was the dependent variable. Ordinal logistic regression analysis was used to compare changes in ARAT subscores according to paralysis severity before treatment. We implemented a longitudinal, prospective, interventional, uncontrolled, and multicenter cohort design and analyzed a dataset of 907 patients with stroke hemiplegia. The largest treatment-related changes were observed in the Limited recovery group for upper limb motor paralysis and the Full recovery group for quality-of-life activities using the paralyzed upper limb. These results will help predict treatment effects and determine exercises and goal movements for occupational therapy after rTMS. Full article
(This article belongs to the Special Issue Transcranial Magnetic Stimulation: New Research)
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