Controversies in Obstructive Sleep Apnea (OSA) Pathophysiology, Diagnosis and Treatment
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurosurgery and Neuroanatomy".
Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 4135
Special Issue Editor
Interests: sleep disordered breathing pathophysiology, diagnosis and therapy; hearing loss diagnosis and surgical treatment; head and neck oncology diagnosis and surgical treatment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder, characterized by a quite complex and multifactorial pathophysiology. Four physiological traits have recently been identified, which include an anatomical upper airway collapsibility, poor muscle responsiveness, low arousal threshold, and high loop gain. Several controversies are still extensively reported in the literature regarding different methods for the identification of anatomical and non-anatomical OSA phenotype traits, including CPAP dials in sleep labs, the mean inspiratory flow during flow limitations, airflow shapes, negative expiratory pressures, diagnostic PSG findings, and recent advances in imaging techniques, photogrammetry, and the acoustic analysis of snoring.
Since its introduction in 1990, drug-induced sleep endoscopy has been employed for the assessment of upper airway obstruction during apnea, and in the last three decades, considerable developments and progress have been achieved in fine-tuning this procedure and addressing various controversies.
The OSA treatment has undergone significant changes in recent years, other than CPAP therapy, the main non-invasive treatments including the intraoral negative airway pressure or mandibular advancement device. Palatal surgical procedures include minimally invasive radiofrequency and modified pharyngoplasties, with tongue surgery also having been changed from minimally invasive radiofrequency to tongue suspension and tongue base resection. Finally, the conventional maxillo-mandibular advancement is being developed into a minimally invasive version. Based on the clinical evidence, a customized OSA treatment remains an open-question field of research.
The aim of this Special Issue is to analyze the updated literature regarding the most important controversial points of the pathophysiology, diagnosis and treatment of OSA.
We welcome prospective, retrospective and meta-analysis papers concerning this topic.
Prof. Dr. Andrea De Vito
Guest Editor
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Keywords
- obstructive sleep apnea
- critical closing pressure
- drug-induced sleep endoscopy
- pharyngoplasty
- robotic surgery
- radiofrequency
- mandibular advancement device
