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Brain Sciences
Special Issues
Epilepsy Surgery and Neuromodulation
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Epilepsy Surgery and Neuromodulation

A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: closed (10 September 2020) | Viewed by 11308

Special Issue Editor

Dr. Churl-Su Kwon

E-Mail Website
Guest Editor
Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, United States
Interests: epilepsy; funtional neurosurgery; deep brain stimulation; neuromodulation; neurophysiology

Special Issue Information

Dear Colleagues,

About 30% of epilepsy cases are drug-resistant and require nonpharmacological treatment. Resective epilepsy surgery remains a vastly underutilized therapy for these patients despite its efficacy shown in randomized controlled trials. Furthermore, a considerable number of those who are drug-resistant will not be candidates for resective surgery due to multifocality, an extensive network or having an epileptogenic zone in the eloquent cortex. Electrical stimulation for the treatment of drug-resistant epilepsy is increasingly being utilized in these patients.

We would like to invite you to contribute to this Special issue of Brain Sciences. This Issue is dedicated to indications, mechanisms of action, safety, efficacy, and the various modes of neuromodulatory treatments for drug-resistant epilepsy as well as the new developments that are taking place in the field.

Dr. Churl-Su Kwon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epilepsy
  • surgery
  • neuromodulation
  • deep brain stimulation (DBS)
  • responsive neuromodulation (RNS)
  • vagal nerve stimulation (VNS)
  • external trigeminal nerve stimulation (eTNS)
  • repetitive transcranial magnetic stimulation (rTMS)
  • transcranial direct current stimulation (tDCS)
  • machine learning
  • artificial intelligence

Published Papers (2 papers)

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Review

14 pages, 1201 KiB  
Review
Contributions of Imaging to Neuromodulatory Treatment of Drug-Refractory Epilepsy
by Niels Alexander Foit, Andrea Bernasconi and Neda Ladbon-Bernasconi
Brain Sci. 2020, 10(10), 700; https://doi.org/10.3390/brainsci10100700 - 02 Oct 2020
Cited by 2 | Viewed by 2344
Abstract
Epilepsy affects about 1% of the world’s population, and up to 30% of all patients will ultimately not achieve freedom from seizures with anticonvulsive medication alone. While surgical resection of a magnetic resonance imaging (MRI) -identifiable lesion remains the first-line treatment option for [...] Read more.
Epilepsy affects about 1% of the world’s population, and up to 30% of all patients will ultimately not achieve freedom from seizures with anticonvulsive medication alone. While surgical resection of a magnetic resonance imaging (MRI) -identifiable lesion remains the first-line treatment option for drug-refractory epilepsy, surgery cannot be offered to all. Neuromodulatory therapy targeting “seizures” instead of “epilepsy” has emerged as a valuable treatment option for these patients, including invasive procedures such as deep brain stimulation (DBS), responsive neurostimulation (RNS) and peripheral approaches such as vagus nerve stimulation (VNS). The purpose of this review is to provide in-depth information on current concepts and evidence on network-level aspects of drug-refractory epilepsy. We reviewed the current evidence gained from studies utilizing advanced imaging methodology, with a specific focus on their contributions to neuromodulatory therapy. Full article
(This article belongs to the Special Issue Epilepsy Surgery and Neuromodulation)
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18 pages, 2791 KiB  
Review
A Review of Neurostimulation for Epilepsy in Pediatrics
by Keith Starnes, Kai Miller, Lily Wong-Kisiel and Brian Nils Lundstrom
Brain Sci. 2019, 9(10), 283; https://doi.org/10.3390/brainsci9100283 - 18 Oct 2019
Cited by 61 | Viewed by 8369
Abstract
Neurostimulation for epilepsy refers to the application of electricity to affect the central nervous system, with the goal of reducing seizure frequency and severity. We review the available evidence for the use of neurostimulation to treat pediatric epilepsy, including vagus nerve stimulation (VNS), [...] Read more.
Neurostimulation for epilepsy refers to the application of electricity to affect the central nervous system, with the goal of reducing seizure frequency and severity. We review the available evidence for the use of neurostimulation to treat pediatric epilepsy, including vagus nerve stimulation (VNS), responsive neurostimulation (RNS), deep brain stimulation (DBS), chronic subthreshold cortical stimulation (CSCS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). We consider possible mechanisms of action and safety concerns, and we propose a methodology for selecting between available options. In general, we find neurostimulation is safe and effective, although any high quality evidence applying neurostimulation to pediatrics is lacking. Further research is needed to understand neuromodulatory systems, and to identify biomarkers of response in order to establish optimal stimulation paradigms. Full article
(This article belongs to the Special Issue Epilepsy Surgery and Neuromodulation)
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