Novel Developments in Tinnitus and Heterogeneity

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Systems Neuroscience".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 4556

Special Issue Editors

Institute for Physical and Information Technologies (ITEFI), Spanish National Research Council (CSIC), Madrid, Spain
Interests: tinnitus assessment; counselling of tinnitus; sound therapies of tinnitus
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Guest Editor
Institute for Physical and Information Technologies (ITEFI), Spanish National Research Council (CSIC), Madrid, Spain
Interests: tinnitus; hearing loss; sound therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tinnitus is a highly heterogeneous auditory disorder. At the input side, there are many risk factors that may trigger tinnitus, including hearing loss, vestibular disorders, migraines and chronic headaches, psychiatric conditions (stress, anxiety and depression), cervical and temporomandibular junction troubles, and head trauma. Tinnitus can be also triggered by various mechanisms, including hyperactivity, hypersynchrony, cortical tonotopic map reorganization, or ion quantum tunneling. Additionally, there are no objective biomarkers available for tinnitus, which make its diagnosis even more difficult. Tinnitus patients cannot be described as a homogeneous group, as they are affected by many different psychological and personality traits, as well as by sociodemographic factors. Therefore, this non-uniform patient pattern with high risk factor diversity demonstrates a rather variable response, including tinnitus perception (laterality, pitch and loudness), comorbidities (hyperacusis and emotional disorders), tinnitus severity (distress), and treatment response. An enhanced understanding of tinnitus heterogeneity is desirable in order to better define the subtypes of this disorder for which personalized treatments could be optimized.

The aim of the current Special Issue is to present recent findings within this field of research, in order to provide new insights on some of these topics. Authors are invited to submit innovative research that addresses this broad range of themes related to tinnitus heterogeneity. In particular, we aim to present advances in tinnitus research that lead us to design improved customized treatments that help to alleviate the most severe effects of tinnitus in patients.

Authors are invited to submit relevant original research articles, as well as opinion and review papers.

Dr. Pedro Cobo
Dr. Maria Cuesta
Guest Editors

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Keywords

  • tinnitus heterogeneity
  • tinnitus sub-typing
  • tinnitus perception
  • tinnitus mechanisms
  • tinnitus risk factors
  • tinnitus comorbidities
  • personality and psychological traits of tinnitus
  • tinnitus severity
  • tinnitus treatments

Published Papers (2 papers)

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Research

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13 pages, 1903 KiB  
Article
A Heterogeneous Sample of a Spanish Tinnitus Cohort
by María Cuesta and Pedro Cobo
Brain Sci. 2023, 13(4), 652; https://doi.org/10.3390/brainsci13040652 - 12 Apr 2023
Cited by 1 | Viewed by 1026
Abstract
Taking into account heterogeneity has been highly recommended in tinnitus studies both to disentangle all diverse factors that can contribute to their complexity and to design personalized treatments. To this aim, a heterogeneous sample of 270 tinnitus subjects is analyzed considering the gender [...] Read more.
Taking into account heterogeneity has been highly recommended in tinnitus studies both to disentangle all diverse factors that can contribute to their complexity and to design personalized treatments. To this aim, a heterogeneous sample of 270 tinnitus subjects is analyzed considering the gender (male/female), hearing condition (hearing-impaired/normal-hearing), and tinnitus severity (compensated/decompensated) subgroups. Two categorical variables (tinnitus laterality and tinnitus sound type) and four quantitative variables (average auditory threshold, age of tinnitus onset, tinnitus frequency, and tinnitus severity) are used. The percentages (for categorical variables) and mean values (for quantitative variables) of the whole sample are compared with these of each subgroup. Furthermore, correlational and hypothesis testing is applied to calculate the correlation coefficients and statistical significance, respectively. The results show that the male and female subgroups contrast in the sound type and frequency of their tinnitus, hearing-impaired and normal-hearing individuals differ, in addition, in their average auditory threshold, and the compensated/decompensated tinnitus subgroup provides significantly distinct values in tinnitus laterality and tinnitus sound. Full article
(This article belongs to the Special Issue Novel Developments in Tinnitus and Heterogeneity)
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Review

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26 pages, 600 KiB  
Review
Tinnitus, Suicide, and Suicidal Ideation: A Scoping Review of Primary Research
by Carol MacDonald, Charlotte Caimino, Georgina Burns-O’Connell, Douglas Hartley, Joanna Lockwood, Magdalena Sereda, William Whitmer, Rilana Cima, Laura Turton and Derek J. Hoare
Brain Sci. 2023, 13(10), 1496; https://doi.org/10.3390/brainsci13101496 - 23 Oct 2023
Cited by 2 | Viewed by 2957
Abstract
Tinnitus (the perception of sound in the absence of any corresponding external source) is highly prevalent and can be distressing. There are unanswered questions about how tinnitus, suicidal thoughts, and suicidal behaviours co-occur and interact. To establish the extent of scientific literature, this [...] Read more.
Tinnitus (the perception of sound in the absence of any corresponding external source) is highly prevalent and can be distressing. There are unanswered questions about how tinnitus, suicidal thoughts, and suicidal behaviours co-occur and interact. To establish the extent of scientific literature, this scoping review catalogued primary reports addressing the associations between tinnitus, suicidal ideation, attempted suicide, and death by suicide. We searched OvidSP, Medline, EMBASE, PsycINFO, CINAHL, Google Scholar, EThoS, and ProQuest for all studies and case reports on ideation and/or attempted and/or completed suicide in the context of tinnitus. Twenty-three studies were included, and data were charted according to study type. Several epidemiological and other observational studies gave evidence of risk factors and an association between suicidal ideation, suicidal behaviour, and tinnitus. However, there was no evidence of the direction of causality. Qualitative studies are indicated to explore the patient’s experience and understand the dynamics of any interaction between tinnitus and suicidal thoughts and behaviours. A theory-informed model of tinnitus and suicide needs to be developed to inform the development of interventions and how tinnitus patients are supported clinically. Full article
(This article belongs to the Special Issue Novel Developments in Tinnitus and Heterogeneity)
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