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Biosensors
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Novel Materials for Electrochemical Biosensors
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Novel Materials for Electrochemical Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 12319

Special Issue Editor

Dr. Tzu-Yen Huang

E-Mail Website
Guest Editor
Neutron Group, National Synchrotron Radiation Research Center (NSRRC), Hsinchu 300, Taiwan
Interests: electrochemical sensors; biosensors; nanocomposites; polymers; neutron reflectometry and X-ray scattering techniques

Special Issue Information

Dear Colleagues,

Electrochemical sensors are accurate, fast, and inexpensive analytical methods with the advantage of easily integrating into electronic devices, and are widely employed in the fields of healthcare, environmental pollutants, and food contaminants. Surface modification of working electrodes offers a sensor with novel and versatile properties. The electrode surface can be modified via adsorption, self-assembling, covalent bonding, and polymerization. The fabrication of modified electrodes is a facilitative approach that can provide modification materials suitable to practical application. Surface modification plays a critical role in improving the performance of sensors, and has the following advantages. First, it obtains physical and chemical properties from the modifiers. Second, it reduces interference and provides better selectivity towards analytes. Third, it enhances sensitivity by having a larger electrochemical active surface area. Fourth, it has fast diffusion and preconcentration of analytes at the electrode surface. Fifth, it reduces fouling in electrochemical sensors.

In this Special Issue, we will focus on the development of novel materials for electrochemical biosensors. These modification materials can be carbon-based materials, metal oxides, polymers, small molecules, biomolecules, enzymes, and antibodies. Novel materials play an important role in boosting the performance of electrochemical biosensors. In this Special Issue, we seek unique research and efforts to enhance and expand the significant field of electrochemical biosensors.

Dr. Tzu-Yen Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Electrochemical sensors
  • Biosensors Electrochemistry
  • Modified electrodes
  • Nanomaterials
  • Nanocomposites
  • Graphene/carbon nanotubes
  • Transition metal dichalcogenides/metal oxides
  • Metal–organic frameworks
  • Polymers/small molecules
  • Enzymes
  • DNA

Published Papers (3 papers)

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Research

15 pages, 2577 KiB  
Article
Developing Activated Carbon Veil Electrode for Sensing Salivary Uric Acid
by Maria A. Bukharinova, Natalia Yu. Stozhko, Elizaveta A. Novakovskaya, Ekaterina I. Khamzina, Aleksey V. Tarasov and Sergey V. Sokolkov
Biosensors 2021, 11(8), 287; https://doi.org/10.3390/bios11080287 - 20 Aug 2021
Cited by 9 | Viewed by 2660
Abstract
The paper describes the development of a carbon veil-based electrode (CVE) for determining uric acid (UA) in saliva. The electrode was manufactured by lamination technology, electrochemically activated and used as a highly sensitive voltammetric sensor (CVEact). Potentiostatic polarization of the electrode [...] Read more.
The paper describes the development of a carbon veil-based electrode (CVE) for determining uric acid (UA) in saliva. The electrode was manufactured by lamination technology, electrochemically activated and used as a highly sensitive voltammetric sensor (CVEact). Potentiostatic polarization of the electrode at 2.0 V in H2SO4 solution resulted in a higher number of oxygen and nitrogen-containing groups on the electrode surface; lower charge transfer resistance; a 1.5 times increase in the effective surface area and a decrease in the UA oxidation potential by over 0.4 V, compared with the non-activated CVE, which was confirmed by energy dispersive X-ray spectroscopy, electrochemical impedance spectroscopy, chronoamperometry and linear sweep voltammetry. The developed sensor is characterized by a low detection limit of 0.05 µM and a wide linear range (0.09–700 µM). The results suggest that the sensor has perspective applications for quick determination of UA in artificial and human saliva. RSD does not exceed 3.9%, and recovery is 96–105%. UA makes a significant contribution to the antioxidant activity (AOA) of saliva (≈60%). In addition to its high analytical characteristics, the important advantages of the proposed CVEact are the simple, scalable, and cost-effective manufacturing technology and the absence of additional complex and time-consuming modification operations. Full article
(This article belongs to the Special Issue Novel Materials for Electrochemical Biosensors)
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17 pages, 3426 KiB  
Article
Paper-Based Electrochemical Biosensors for Voltammetric Detection of miRNA Biomarkers Using Reduced Graphene Oxide or MoS2 Nanosheets Decorated with Gold Nanoparticle Electrodes
by Hilal Torul, Ece Yarali, Ece Eksin, Abhijit Ganguly, John Benson, Ugur Tamer, Pagona Papakonstantinou and Arzum Erdem
Biosensors 2021, 11(7), 236; https://doi.org/10.3390/bios11070236 - 13 Jul 2021
Cited by 47 | Viewed by 4653
Abstract
Paper-based biosensors are considered simple and cost-efficient sensing platforms for analytical tests and diagnostics. Here, a paper-based electrochemical biosensor was developed for the rapid and sensitive detection of microRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer. Hydrophobic barriers to creating [...] Read more.
Paper-based biosensors are considered simple and cost-efficient sensing platforms for analytical tests and diagnostics. Here, a paper-based electrochemical biosensor was developed for the rapid and sensitive detection of microRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer. Hydrophobic barriers to creating electrode areas were manufactured by wax printing, whereas a three-electrode system was fabricated by a simple stencil approach. A carbon-based working electrode was modified using either reduced graphene oxide or molybdenum disulfide nanosheets modified with gold nanoparticle (AuNPs/RGO, AuNPs/MoS2) hybrid structures. The resulting paper-based biosensors offered sensitive detection of miRNA-155 and miRNA-21 by differential pulse voltammetry (DPV) in only 5.0 µL sample. The duration in our assay from the point of electrode modification to the final detection of miRNA was completed within only 35 min. The detection limits for miRNA-21 and miRNA-155 were found to be 12.0 and 25.7 nM for AuNPs/RGO and 51.6 and 59.6 nM for AuNPs/MoS2 sensors in the case of perfectly matched probe-target hybrids. These biosensors were found to be selective enough to distinguish the target miRNA in the presence of single-base mismatch miRNA or noncomplementary miRNA sequences. Full article
(This article belongs to the Special Issue Novel Materials for Electrochemical Biosensors)
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17 pages, 2713 KiB  
Article
Screen-Printed Glucose Sensors Modified with Cellulose Nanocrystals (CNCs) for Cell Culture Monitoring
by Ye Tang, Konstantinos Petropoulos, Felix Kurth, Hui Gao, Davide Migliorelli, Olivier Guenat and Silvia Generelli
Biosensors 2020, 10(9), 125; https://doi.org/10.3390/bios10090125 - 13 Sep 2020
Cited by 22 | Viewed by 4317
Abstract
Glucose sensors are potentially useful tools for monitoring the glucose concentration in cell culture medium. Here, we present a new, low-cost, and reproducible sensor based on a cellulose-based material, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) oxidized-cellulose nanocrystals (CNCs). This novel biocompatible and inert nanomaterial is employed as [...] Read more.
Glucose sensors are potentially useful tools for monitoring the glucose concentration in cell culture medium. Here, we present a new, low-cost, and reproducible sensor based on a cellulose-based material, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) oxidized-cellulose nanocrystals (CNCs). This novel biocompatible and inert nanomaterial is employed as a polymeric matrix to immobilize and stabilize glucose oxidase in the fabrication of a reproducible, operationally stable, highly selective, cost-effective, screen-printed glucose sensor. The sensors have a linear range of 0.1–2 mM (R2 = 0.999) and a sensitivity of 5.7 ± 0.3 µA cm−2∙mM−1. The limit of detection is 0.004 mM, and the limit of quantification is 0.015 mM. The sensor maintains 92.3 % of the initial current response after 30 consecutive measurements in a 1 mM standard glucose solution, and has a shelf life of 1 month while maintaining high selectivity. We demonstrate the practical application of the sensor by monitoring the glucose consumption of a fibroblast cell culture over the course of several days. Full article
(This article belongs to the Special Issue Novel Materials for Electrochemical Biosensors)
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