Biosensors for Neurodegenerative Diseases and Related Disorders

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 4831

Special Issue Editors


E-Mail Website
Guest Editor
Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Interests: biomarker research; bioassay analytical and clinical validation; electrochemical biosensors; neurodegenerative-disease

E-Mail Website
Guest Editor
Medical School, Department of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy
Interests: biosensor; biomedical applications; amperometry; biological fluids; interferents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The last few years have seen a proliferation of reports and calls for action for the management and early diagnosis of dementia, worldwide. Advances in understanding neurodegenerative disorders are proceeding parallel to the development of novel and innovative technology for disease monitoring and biomarker detection. A wide range of sensors can represent upcoming and promising tools for people affected by neurodegenerative disorders. Sensors and software can measure digital biomarkers and behaviors (e.g., in sleep, mood, physical activity, memory, frailty status, and social activity) from which we can effectively measure and identify changes in outcomes that are clinically meaningful. Biosensors for biomarker detection and therapy monitoring can aid in the management of the disease.In recent years, thanks to advances in material science, numerous optical and electrochemical biosensors have been developed for specific biomarkers detection taking advantage of increasing sensitivity, low cost, and rapid response.This Special Issue will provide the state-of-the-art of novel biosensors in the field of neurodegenerative disease, focusing not only on disease monitoring and early disease detection but also addressing the daily lives of patients.

Prof. Dr. Daniela Uberti
Prof. Dr. Gaia Rocchitta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomarkers
  • Digital biomarkers
  • Medical device
  • Electrochemical and optical biosensor
  • Neurodegenerative disease

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 1648 KiB  
Article
Kynurenic Acid Electrochemical Immunosensor: Blood-Based Diagnosis of Alzheimer’s Disease
by Jose Marrugo-Ramírez, Montserrat Rodríguez-Núñez, M.-Pilar Marco, Mónica Mir and Josep Samitier
Biosensors 2021, 11(1), 20; https://doi.org/10.3390/bios11010020 - 12 Jan 2021
Cited by 12 | Viewed by 3979
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by a functional deterioration of the brain. Currently, there are selected biomarkers for its diagnosis in cerebrospinal fluid. However, its extraction has several disadvantages for the patient. Therefore, there is an urgent need for a [...] Read more.
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by a functional deterioration of the brain. Currently, there are selected biomarkers for its diagnosis in cerebrospinal fluid. However, its extraction has several disadvantages for the patient. Therefore, there is an urgent need for a detection method using sensitive and selective blood-based biomarkers. Kynurenic acid (KYNA) is a potential biomarker candidate for this purpose. The alteration of the KYNA levels in blood has been related with inflammatory processes in the brain, produced as a protective function when neurons are damaged. This paper describes a novel electrochemical immunosensor for KYNA detection, based on successive functionalization multi-electrode array. The resultant sensor was characterized by cyclic voltammetry (CV), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS). The proposed biosensor detects KYNA within a linear calibration range from 10 pM to 100 nM using CA and EIS, obtaining a limit of detection (LOD) of 16.9 pM and 37.6 pM in buffer, respectively, being the lowest reported LOD for this biomarker. Moreover, to assess our device closer to the real application, the developed immunosensor was also tested under human serum matrix, obtaining an LOD of 391.71 pM for CA and 278.8 pM for EIS with diluted serum. Full article
(This article belongs to the Special Issue Biosensors for Neurodegenerative Diseases and Related Disorders)
Show Figures

Graphical abstract

Back to TopTop