Special Issue "Application of Functional Nucleic Acid Based Biosensors in Cell or Tissue Analysis"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 121

Special Issue Editor

Prof. Dr. Fujian Huang
E-Mail Website
Guest Editor
Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China
Interests: single cell analysis DNA nanotechnology

Special Issue Information

Dear Colleagues,

Functional nucleic acids, such as aptamers and DNAzymes, have excellent flexibility, are convenient in their structural design, and thus possess significant advantages as recognition elements (probes) in biosensing. Combining functional nucleic acids with signal amplification methods offers a promising technique by which to achieve signal-amplified target detection. Functional DNA nanostructures are easily constructed and highly programmable, such that shapes and their sizes can be designed. Compared to small molecules, functional nucleic acid structures are more efficiently endocytosed by cells. For example, the structure of a tetrahedron can be transferred to the cell without transfection. In addition, sensitive and accurate diagnosis and treatment can be achieved by integrating various units into functional nucleic acid probes, such as imaging agents, aptamers for cancer targets, and cancer therapeutic drugs. In recent decades, various biosensing strategies based on functional nucleic acids and functional DNA nanostructures with amplified signals have been developed to achieve signal-amplified cell imaging and tissue analysis. The labeling of DNA nanostructures with fluorescent dyes is one of the techniques most often employed to track the spatial location of biomarkers inside cells. Many in situ amplifications have been developed for cell imaging and tissue analysis via FRET signals. Encouraged by the developments concerning functional nucleic acids in cell imaging and tissues analysis, greater valuable information of the cell or tissue should be provided.

Prof. Dr. Fujian Huang
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • functional nucleic acids probe
  • aptamer
  • DNAzyme
  • DNA nanostructure
  • signal amplification
  • biosensing
  • cell imaging
  • tissue analysis
  • fluorescence signal

Published Papers

This special issue is now open for submission.
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