Special Issue "Application of Functional Nucleic Acid Based Biosensors in Cell or Tissue Analysis"
Deadline for manuscript submissions: 29 February 2024 | Viewed by 121
Functional nucleic acids, such as aptamers and DNAzymes, have excellent flexibility, are convenient in their structural design, and thus possess significant advantages as recognition elements (probes) in biosensing. Combining functional nucleic acids with signal amplification methods offers a promising technique by which to achieve signal-amplified target detection. Functional DNA nanostructures are easily constructed and highly programmable, such that shapes and their sizes can be designed. Compared to small molecules, functional nucleic acid structures are more efficiently endocytosed by cells. For example, the structure of a tetrahedron can be transferred to the cell without transfection. In addition, sensitive and accurate diagnosis and treatment can be achieved by integrating various units into functional nucleic acid probes, such as imaging agents, aptamers for cancer targets, and cancer therapeutic drugs. In recent decades, various biosensing strategies based on functional nucleic acids and functional DNA nanostructures with amplified signals have been developed to achieve signal-amplified cell imaging and tissue analysis. The labeling of DNA nanostructures with fluorescent dyes is one of the techniques most often employed to track the spatial location of biomarkers inside cells. Many in situ amplifications have been developed for cell imaging and tissue analysis via FRET signals. Encouraged by the developments concerning functional nucleic acids in cell imaging and tissues analysis, greater valuable information of the cell or tissue should be provided.
Prof. Dr. Fujian Huang
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- functional nucleic acids probe
- DNA nanostructure
- signal amplification
- cell imaging
- tissue analysis
- fluorescence signal