Recent Advances in Nanomaterial-Based Biosensing and Diagnosis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1189

Special Issue Editors

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
Interests: biosensing based on functional nanomaterials; microfluidic paper-based devices; fabricating and controlling solid–liquid interface; non-invasive diagnosis
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Guest Editor
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Interests: ordered nanostructured arrays for nanodevices such as biosensors and gas sensors; interfacial analysis of inorganic–organic interfaces at the micro/nanoscale

Special Issue Information

Dear Colleagues,

Nanomaterials, including carbon nanomaterials, metal nanomaterials, silica nanoparticles, quantum dots, polymeric-based materials, and other functionalized nanoparticles, have attracted the extensive attention of scientists in view of their unique chemical, physical and size properties. They have provided great contributions to the development of biosensors and diagnosis over the past few decades. The ability to tailor the structure and therefore the properties of nanomaterials enables for desirable surface properties, crystallographic orientations, and biological activities, and this allows for the fabrication of novel application platforms for biosensing and diagnosis by improving performance. So far, various nanomaterial-based techniques on account of electrochemistry, chemiluminescence, electrochemiluminescence, fluorescence, surface plasmon resonance, and colorimetric analysis have been developed. Nevertheless, fully satisfying the continued growing demand for application platforms that have the advantages of high sensitivity, low cost, and convenient operation is still a challenge, especially for industry requirements with high-performance fabrication technology. It is believed that multidisciplinary collaborations will remain the focus for the future development of biosensing and diagnosis applications, which will further stimulate research interest from academia and industry. Accordingly, this Special Issue is devoted to a collection of significant advances on innovative research in the fabrication of different types of nanomaterial-based biosensors and diagnosis applications.

Dr. Kang Cui
Dr. Yizhong Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biosensors
  • biosensing
  • health biomarker
  • point-of-care testing
  • bioimaging
  • diagnosis

Published Papers (1 paper)

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Research

13 pages, 1638 KiB  
Article
Gold Nanoprobes for Detection of a Crucial EGFR Deletion for Early Diagnosis of Non-Small-Cell Lung Cancer
by Maria Enea, Anupong Nuekaew, Ricardo Franco and Eulália Pereira
Biosensors 2024, 14(4), 162; https://doi.org/10.3390/bios14040162 - 29 Mar 2024
Viewed by 1005
Abstract
Gold nanoparticles (AuNPs) exhibit improved optical and spectral properties compared to bulk materials, making them suitable for the detection of DNA, RNA, antigens, and antibodies. Here, we describe a simple, selective, and rapid non-cross linking detection assay, using approx. 35 nm spherical Au [...] Read more.
Gold nanoparticles (AuNPs) exhibit improved optical and spectral properties compared to bulk materials, making them suitable for the detection of DNA, RNA, antigens, and antibodies. Here, we describe a simple, selective, and rapid non-cross linking detection assay, using approx. 35 nm spherical Au nanoprobes, for a common mutation occurring in exon 19 of the epidermal growth factor receptor (EGFR), associated with non-small-cell lung cancer cells. AuNPs were synthesized based on the seed-mediated growth method and functionalized with a specific 16 bp thiolated oligonucleotide using a pH-assisted method. Both AuNPs and Au nanoprobes proved to be highly stable and monodisperse through ultraviolet-visible spectrophotometry, dynamic light scattering (DLS), and electrophoretic light scattering (ELS). Our results indicate a detection limit of 1.5 µg mL−1 using a 0.15 nmol dm−3 Au nanoprobe concentration. In conclusion, this work presents an effective possibility for a straightforward, fast, and inexpensive alternative for the detection of DNA sequences related to lung cancer, leading to a potential platform for early diagnosis of lung cancer patients. Full article
(This article belongs to the Special Issue Recent Advances in Nanomaterial-Based Biosensing and Diagnosis)
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