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Biosensors
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Surface-Enhanced Raman Scattering Biosensors
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Surface-Enhanced Raman Scattering Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 14860

Special Issue Editor

Dr. Nicoleta Elena Dina

E-Mail Website
Guest Editor
National Institute for Research and Development of Isotopic and Molecular Technologies, 400293 Cluj Napoca, Romania
Interests: SERS; biosensing; miniaturized devices; PoC devices; clinical applications of SERS; spectral pathology; liquid SERS-based biopsy; SERS based diagnosis; SERS on bacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Like every up-to-date analytical technique with high potential for clinical application, surface-enhanced Raman scattering (SERS) spectroscopy has evolved into a futuristic asset in point-of-care (PoC) analysis. SERS-based biosensing approaches offer promising solutions for identifying pathogens; rapid testing for viruses, glucose or O2 saturation; antibiotic susceptibility testing; early cancer diagnosis or prognosis and various other crucial clinical issues. We herein intend to comprehensively collect relevant SERS biosensors studies with potential in PoC testing and off-site use, meant to improve healthcare accessibility and sustainability.

In this Special Issue we will also provide the latest input resulting from synergistic approaches like SERS and machine learning, SERS-based spectral pathology enhanced by chemometrics and adaptive, robust computational tools or SERS-based setups which integrate digital technology for ultrasensitivity and reliability.

The Special Issue topics include, but are not limited to, the following:

  • Label-free and label-based SERS bioassays;
  • Miniaturized SERS-activated platforms for biosensing;
  • Data augmentation in spectral pathology and diagnosis;
  • Modern and conventional chemometric tools for high-accuracy SERS data analysis;
  • Single-cell SERS detection of morphological variations associated with chronic diseases;
  • Microfluidic SERS-based devices for clinical use;
  • Functional, original SERS-based setups for diagnosis and malignancy monitoring;
  • Nanomaterials’ interaction with viable cells for susceptibility testing, drug delivery and efficient treatment.

Dr. Nicoleta Elena Dina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SERS
  • biosensing
  • miniaturized devices
  • PoC devices
  • clinical applications of SERS
  • SERS-based diagnosis

Published Papers (5 papers)

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Research

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17 pages, 7360 KiB  
Article
Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses
by Cristina M. Muntean, Denisa Cuibus, Sanda Boca, Alexandra Falamas, Nicoleta Tosa, Ioana Andreea Brezeştean, Attila Bende, Lucian Barbu-Tudoran, Rebeca Moldovan, Ede Bodoki and Cosmin Farcǎu
Biosensors 2023, 13(5), 530; https://doi.org/10.3390/bios13050530 - 09 May 2023
Cited by 4 | Viewed by 2384
Abstract
The increasing pollution of surface and groundwater bodies by pharmaceuticals is a general environmental problem requiring routine monitoring. Conventional analytical techniques used to quantify traces of pharmaceuticals are relatively expensive and generally demand long analysis times, associated with difficulties in performing field analyses. [...] Read more.
The increasing pollution of surface and groundwater bodies by pharmaceuticals is a general environmental problem requiring routine monitoring. Conventional analytical techniques used to quantify traces of pharmaceuticals are relatively expensive and generally demand long analysis times, associated with difficulties in performing field analyses. Propranolol, a widely used β-blocker, is representative of an emerging class of pharmaceutical pollutants with a noticeable presence in the aquatic environment. In this context, we focused on developing an innovative, highly accessible analytical platform based on self-assembled metal colloidal nanoparticle films for the fast and sensitive detection of propranolol based on Surface Enhanced Raman Spectroscopy (SERS). The ideal nature of the metal used as the active SERS substrate was investigated by comparing silver and gold self-assembled colloidal nanoparticle films, and the improved enhancement observed on the gold substrate was discussed and supported by Density Functional Theory calculations, optical spectra analyses, and Finite-Difference Time-Domain simulations. Next, direct detection of propranolol at low concentrations was demonstrated, reaching the ppb regime. Finally, we showed that the self-assembled gold nanoparticle films could be successfully used as working electrodes in electrochemical-SERS analyses, opening the possibility of implementing them in a wide array of analytical applications and fundamental studies. This study reports for the first time a direct comparison between gold and silver nanoparticle films and, thus, contributes to a more rational design of nanoparticle-based SERS substrates for sensing applications. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering Biosensors)
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17 pages, 3348 KiB  
Article
SERS Determination of Oxidative Stress Markers in Saliva Using Substrates with Silver Nanoparticle-Decorated Silicon Nanowires
by Anastasia Kanioura, Georgia Geka, Ioannis Kochylas, Vlassis Likodimos, Spiros Gardelis, Anastasios Dimitriou, Nikolaos Papanikolaou, Sotirios Kakabakos and Panagiota Petrou
Biosensors 2023, 13(2), 273; https://doi.org/10.3390/bios13020273 - 14 Feb 2023
Cited by 5 | Viewed by 1675
Abstract
Glutathione and malondialdehyde are two compounds commonly used to evaluate the oxidative stress status of an organism. Although their determination is usually performed in blood serum, saliva is gaining ground as the biological fluid of choice for oxidative stress determination at the point [...] Read more.
Glutathione and malondialdehyde are two compounds commonly used to evaluate the oxidative stress status of an organism. Although their determination is usually performed in blood serum, saliva is gaining ground as the biological fluid of choice for oxidative stress determination at the point of need. For this purpose, surface-enhanced Raman spectroscopy (SERS), which is a highly sensitive method for the detection of biomolecules, could offer additional advantages regarding the analysis of biological fluids at the point of need. In this work, silicon nanowires decorated with silver nanoparticles made by metal-assisted chemical etching were evaluated as substrates for the SERS determination of glutathione and malondialdehyde in water and saliva. In particular, glutathione was determined by monitoring the reduction in the Raman signal obtained from substrates modified with crystal violet upon incubation with aqueous glutathione solutions. On the other hand, malondialdehyde was detected after a reaction with thiobarbituric acid to produce a derivative with a strong Raman signal. The detection limits achieved after optimization of several assay parameters were 50 and 3.2 nM for aqueous solutions of glutathione and malondialdehyde, respectively. In artificial saliva, however, the detection limits were 2.0 and 0.32 μM for glutathione and malondialdehyde, respectively, which are, nonetheless, adequate for the determination of these two markers in saliva. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering Biosensors)
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12 pages, 2523 KiB  
Article
Machine Learning Assisted Real-Time Label-Free SERS Diagnoses of Malignant Pleural Effusion due to Lung Cancer
by Jayakumar Perumal, Pyng Lee, Kapil Dev, Hann Qian Lim, U. S. Dinish and Malini Olivo
Biosensors 2022, 12(11), 940; https://doi.org/10.3390/bios12110940 - 28 Oct 2022
Cited by 2 | Viewed by 1953
Abstract
More than half of all pleural effusions are due to malignancy of which lung cancer is the main cause. Pleural effusions can complicate the course of pneumonia, pulmonary tuberculosis, or underlying systemic disease. We explore the application of label-free surface-enhanced Raman spectroscopy (SERS) [...] Read more.
More than half of all pleural effusions are due to malignancy of which lung cancer is the main cause. Pleural effusions can complicate the course of pneumonia, pulmonary tuberculosis, or underlying systemic disease. We explore the application of label-free surface-enhanced Raman spectroscopy (SERS) as a point of care (POC) diagnostic tool to identify if pleural effusions are due to lung cancer or to other causes (controls). Lung cancer samples showed specific SERS spectral signatures such as the position and intensity of the Raman band in different wave number region using a novel silver coated silicon nanopillar (SCSNP) as a SERS substrate. We report a classification accuracy of 85% along with a sensitivity and specificity of 87% and 83%, respectively, for the detection of lung cancer over control pleural fluid samples with a receiver operating characteristics (ROC) area under curve value of 0.93 using a PLS-DA binary classifier to distinguish between lung cancer over control subjects. We have also evaluated discriminative wavenumber bands responsible for the distinction between the two classes with the help of a variable importance in projection (VIP) score. We found that our label-free SERS platform was able to distinguish lung cancer from pleural effusions due to other causes (controls) with higher diagnostic accuracy. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering Biosensors)
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Review

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33 pages, 8158 KiB  
Review
A Review on Integrated ZnO-Based SERS Biosensors and Their Potential in Detecting Biomarkers of Neurodegenerative Diseases
by Alia Colniță, Vlad-Alexandru Toma, Ioana Andreea Brezeștean, Muhammad Ali Tahir and Nicoleta Elena Dina
Biosensors 2023, 13(5), 499; https://doi.org/10.3390/bios13050499 - 25 Apr 2023
Cited by 3 | Viewed by 2047
Abstract
Surface-enhanced Raman spectroscopy (SERS) applications in clinical diagnosis and spectral pathology are increasing due to the potential of the technique to bio-barcode incipient and differential diseases via real-time monitoring of biomarkers in fluids and in real-time via biomolecular fingerprinting. Additionally, the rapid advancements [...] Read more.
Surface-enhanced Raman spectroscopy (SERS) applications in clinical diagnosis and spectral pathology are increasing due to the potential of the technique to bio-barcode incipient and differential diseases via real-time monitoring of biomarkers in fluids and in real-time via biomolecular fingerprinting. Additionally, the rapid advancements in micro/nanotechnology have a visible influence in all aspects of science and life. The miniaturization and enhanced properties of materials at the micro/nanoscale transcended the confines of the laboratory and are revolutionizing domains such as electronics, optics, medicine, and environmental science. The societal and technological impact of SERS biosensing by using semiconductor-based nanostructured smart substrates will be huge once minor technical pitfalls are solved. Herein, challenges in clinical routine testing are addressed in order to understand the context of how SERS can perform in real, in vivo sampling and bioassays for early neurodegenerative disease (ND) diagnosis. The main interest in translating SERS into clinical practice is reinforced by the practical advantages: portability of the designed setups, versatility in using nanomaterials of various matter and costs, readiness, and reliability. As we will present in this review, in the frame of technology readiness levels (TRL), the current maturity reached by semiconductor-based SERS biosensors, in particular that of zinc oxide (ZnO)-based hybrid SERS substrates, is situated at the development level TRL 6 (out of 9 levels). Three-dimensional, multilayered SERS substrates that provide additional plasmonic hot spots in the z-axis are of key importance in designing highly performant SERS biosensors for the detection of ND biomarkers. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering Biosensors)
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31 pages, 6083 KiB  
Review
Miniaturized Raman Instruments for SERS-Based Point-of-Care Testing on Respiratory Viruses
by Ahmed Ali, Ezekiel Edward Nettey-Oppong, Elijah Effah, Chan Yeong Yu, Riaz Muhammad, Toufique Ahmed Soomro, Kyung Min Byun and Seung Ho Choi
Biosensors 2022, 12(8), 590; https://doi.org/10.3390/bios12080590 - 02 Aug 2022
Cited by 20 | Viewed by 4317
Abstract
As surface-enhanced Raman scattering (SERS) has been used to diagnose several respiratory viruses (e.g., influenza A virus subtypes such as H1N1 and the new coronavirus SARS-CoV-2), SERS is gaining popularity as a method for diagnosing viruses at the point-of-care. Although the prior and [...] Read more.
As surface-enhanced Raman scattering (SERS) has been used to diagnose several respiratory viruses (e.g., influenza A virus subtypes such as H1N1 and the new coronavirus SARS-CoV-2), SERS is gaining popularity as a method for diagnosing viruses at the point-of-care. Although the prior and quick diagnosis of respiratory viruses is critical in the outbreak of infectious disease, ELISA, PCR, and RT-PCR have been used to detect respiratory viruses for pandemic control that are limited for point-of-care testing. SERS provides quantitative data with high specificity and sensitivity in a real-time, label-free, and multiplex manner recognizing molecular fingerprints. Recently, the design of Raman spectroscopy system was simplified from a complicated design to a small and easily accessible form that enables point-of-care testing. We review the optical design (e.g., laser wavelength/power and detectors) of commercialized and customized handheld Raman instruments. As respiratory viruses have prominent risk on the pandemic, we review the applications of handheld Raman devices for detecting respiratory viruses. By instrumentation and commercialization advancements, the advent of the portable SERS device creates a fast, accurate, practical, and cost-effective analytical method for virus detection, and would continue to attract more attention in point-of-care testing. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering Biosensors)
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