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Biosensors
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Nanomaterial Based Biosensors for Biomedical Applications
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Nanomaterial Based Biosensors for Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 8555

Special Issue Editor

Dr. Jian Ju

E-Mail Website
Guest Editor
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
Interests: nanomaterials; biosensors; electrochemical sensors; SERS sensors; microneedle-based biosensors

Special Issue Information

Dear Colleagues,

Nanomaterials-based biosensors designed depending on the sensitive stimuli-responsive of nanomaterials can respond to pH, temperature, electricity, stress, light, and chemical or biological stimuli. In the past several decades, nanomaterial-based biosensors have been widely used in many different fields, including environmental protection, enzymatic processes, and applications taking advantage of their ability to diagnose health issues.

Predictive and preventative measures enabled by biosensors represent a potential advancement in biomedical applications, which would involve the identification of individuals likely to suffer from a disease and the development of methods to combat the disease development before it takes place. Nanomaterials-based biosensors have already become an important avenue of biomedical research due to their generally sensitive, selective, and convenient operation.

In this Special Issue, we aim to gather the most advanced nanomaterials-based biosensor technologies that advance the field of biomedical applications; original research articles, short communications, and reviews are all welcome.

Dr. Jian Ju
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biosensors
  • optical sensing
  • electrochemical sensing
  • biomarker detection
  • cancer diagnostics
  • point-of-care biosensors

Published Papers (4 papers)

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Research

26 pages, 3410 KiB  
Article
Mobile Point-of-Care Device Using Molecularly Imprinted Polymer-Based Chemosensors Targeting Interleukin-1β Biomarker
by Rowoon Park, Sangheon Jeon, Jae Won Lee, Jeonghwa Jeong, Young Woo Kwon, Sung Hyun Kim, Joonkyung Jang, Dong-Wook Han and Suck Won Hong
Biosensors 2023, 13(12), 1013; https://doi.org/10.3390/bios13121013 - 05 Dec 2023
Cited by 1 | Viewed by 1764
Abstract
Molecularly imprinted polymers (MIPs) have garnered significant attention as a promising material for engineering specific biological receptors with superior chemical complementarity to target molecules. In this study, we present an electrochemical biosensing platform incorporating MIP films for the selective detection of the interleukin-1β [...] Read more.
Molecularly imprinted polymers (MIPs) have garnered significant attention as a promising material for engineering specific biological receptors with superior chemical complementarity to target molecules. In this study, we present an electrochemical biosensing platform incorporating MIP films for the selective detection of the interleukin-1β (IL-1β) biomarker, particularly suitable for mobile point-of-care testing (POCT) applications. The IL-1β-imprinted biosensors were composed of poly(eriochrome black T (EBT)), including an interlayer of poly(3,4-ethylene dioxythiophene) and a 4-aminothiophenol monolayer, which were electrochemically polymerized simultaneously with template proteins (i.e., IL-1β) on custom flexible screen-printed carbon electrodes (SPCEs). The architecture of the MIP films was designed to enhance the sensor sensitivity and signal stability. This approach involved a straightforward sequential-electropolymerization process and extraction for leaving behind cavities (i.e., rebinding sites), resulting in the efficient production of MIP-based biosensors capable of molecular recognition for selective IL-1β detection. The electrochemical behaviors were comprehensively investigated using cyclic voltammograms and electrochemical impedance spectroscopy responses to assess the imprinting effect on the MIP films formed on the SPCEs. In line with the current trend in in vitro diagnostic medical devices, our simple and effective MIP-based analytical system integrated with mobile POCT devices offers a promising route to the rapid detection of biomarkers, with particular potential for periodontitis screening. Full article
(This article belongs to the Special Issue Nanomaterial Based Biosensors for Biomedical Applications)
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15 pages, 2879 KiB  
Article
A Methylene Blue-Enhanced Nanostructured Electrochemical Immunosensor for H-FABP Myocardial Injury Biomarker
by Cecília Maciel Prado, Paula Angélica Burgos Ferreira, Lucas Alves de Lima, Erika Ketlem Gomes Trindade and Rosa Fireman Dutra
Biosensors 2023, 13(9), 873; https://doi.org/10.3390/bios13090873 - 07 Sep 2023
Viewed by 1170
Abstract
A sensitive electrochemical immunosensor for the detection of the heart-type fatty acid binding protein (HFABP), an earlier biomarker for acute myocardial infarction than Troponins, is described. The sensing platform was enhanced with methylene blue (MB) redox coupled to carbon nanotubes (CNT) assembled on [...] Read more.
A sensitive electrochemical immunosensor for the detection of the heart-type fatty acid binding protein (HFABP), an earlier biomarker for acute myocardial infarction than Troponins, is described. The sensing platform was enhanced with methylene blue (MB) redox coupled to carbon nanotubes (CNT) assembled on a polymer film of polythionine (PTh). For this strategy, monomers of thionine rich in amine groups were electrosynthesized by cyclic voltammetry on the immunosensor’s gold surface, forming an electroactive film with excellent electron transfer capacity. Stepwise sensor surface preparation was electrochemically characterized at each step and scanning electronic microscopy was carried out showing all the preparation steps. The assembled sensor platform combines MB and PTh in a synergism, allowing sensitive detection of the H-FABP in a linear response from 3.0 to 25.0 ng∙mL−1 with a limit of detection of 1.47 ng∙mL−1 HFABP that is similar to the clinical level range for diagnostics. H-FABP is a newer powerful biomarker for distinguishing between unstable angina and acute myocardial infarction. Full article
(This article belongs to the Special Issue Nanomaterial Based Biosensors for Biomedical Applications)
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12 pages, 3436 KiB  
Article
Cobalt–Nitrogen Co-Doped Carbon as Highly Efficient Oxidase Mimics for Colorimetric Assay of Nitrite
by Dalei Lin, Shuzhi Wu, Shushu Chu and Yizhong Lu
Biosensors 2023, 13(7), 748; https://doi.org/10.3390/bios13070748 - 20 Jul 2023
Cited by 1 | Viewed by 1311
Abstract
Transition metal-N-doped carbon has been demonstrated to mimic natural enzyme activity; in this study, cobalt–nitrogen co-doped carbon (Co-N-C) nanomaterial was developed, and it could be an oxidase mimic. Firstly, Co-N-C with oxidase-like activity boosts the chromogenic reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce the [...] Read more.
Transition metal-N-doped carbon has been demonstrated to mimic natural enzyme activity; in this study, cobalt–nitrogen co-doped carbon (Co-N-C) nanomaterial was developed, and it could be an oxidase mimic. Firstly, Co-N-C with oxidase-like activity boosts the chromogenic reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce the oxidized TMB (oxTMB). And the aromatic primary amino group of oxTMB reacts with nitrite (NO2−) to form diazo groups. Based on this background, we developed a cascade system of a Co-N-C-catalyzed oxidation reaction and a diazotization reaction for nitrite determination. The low detection limit (0.039 μM) indicates that Co-N-C is superior compared with the vast majority of previously reported nitrite assays. This study not only provides a novel nanozyme with sufficiently dispersed active sites, but it also further applies it to the determination of nitrite, which is expected to expand the application of nanozymes in colorimetric analysis. Full article
(This article belongs to the Special Issue Nanomaterial Based Biosensors for Biomedical Applications)
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14 pages, 2366 KiB  
Article
Microfluidic Platform Integrated with Carbon Nanofibers-Decorated Gold Nanoporous Sensing Device for Serum PSA Quantification
by Emiliano Felici, Matías D. Regiart, Sirley V. Pereira, Francisco G. Ortega, Lúcio Angnes, Germán A. Messina and Martín A. Fernández-Baldo
Biosensors 2023, 13(3), 390; https://doi.org/10.3390/bios13030390 - 16 Mar 2023
Cited by 2 | Viewed by 3638
Abstract
Prostate cancer is a disease with a high incidence and mortality rate in men worldwide. Serum prostate-specific antigens (PSA) are the main circulating biomarker for this disease in clinical practices. In this work, we present a portable and reusable microfluidic device for PSA [...] Read more.
Prostate cancer is a disease with a high incidence and mortality rate in men worldwide. Serum prostate-specific antigens (PSA) are the main circulating biomarker for this disease in clinical practices. In this work, we present a portable and reusable microfluidic device for PSA quantification. This device comprises a polymethyl methacrylate microfluidic platform coupled with electrochemical detection. The platinum working microelectrode was positioned in the outflow region of the microchannel and was modified with carbon nanofibers (CNF)-decorated gold nanoporous (GNP) structures by the dynamic hydrogen bubble template method, through the simultaneous electrodeposition of metal precursors in the presence of CNF. CNF/GNP structures exhibit attractive properties, such as a large surface to volume ratio, which increases the antibody’s immobilization capacity and the electroactive area. CNFs/GNP structures were characterized by scanning electron microscopy, energy dispersive spectrometry, and cyclic voltammetry. Anti-PSA antibodies and HRP were employed for the immune-electrochemical reaction. The detection limit for the device was 5 pg mL−1, with a linear range from 0.01 to 50 ng mL−1. The coefficients of variation within and between assays were lower than 4.40%, and 6.15%, respectively. Additionally, its clinical performance was tested in serum from 30 prostate cancer patients. This novel device was a sensitive, selective, portable, and reusable tool for the serological diagnosis and monitoring of prostate cancer. Full article
(This article belongs to the Special Issue Nanomaterial Based Biosensors for Biomedical Applications)
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