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Biosensors
Special Issues
Nanomaterial Based Biosensors for Biomedical Applications
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Special Issue "Nanomaterial Based Biosensors for Biomedical Applications"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 1832

Special Issue Editor

Dr. Jian Ju

E-Mail Website
Guest Editor
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
Interests: nanomaterials; biosensors; electrochemical sensors; SERS sensors; microneedle-based biosensors

Special Issue Information

Dear Colleagues,

Nanomaterials-based biosensors designed depending on the sensitive stimuli-responsive of nanomaterials can respond to pH, temperature, electricity, stress, light, and chemical or biological stimuli. In the past several decades, nanomaterial-based biosensors have been widely used in many different fields, including environmental protection, enzymatic processes, and applications taking advantage of their ability to diagnose health issues.

Predictive and preventative measures enabled by biosensors represent a potential advancement in biomedical applications, which would involve the identification of individuals likely to suffer from a disease and the development of methods to combat the disease development before it takes place. Nanomaterials-based biosensors have already become an important avenue of biomedical research due to their generally sensitive, selective, and convenient operation.

In this Special Issue, we aim to gather the most advanced nanomaterials-based biosensor technologies that advance the field of biomedical applications; original research articles, short communications, and reviews are all welcome.

Dr. Jian Ju
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biosensors
  • optical sensing
  • electrochemical sensing
  • biomarker detection
  • cancer diagnostics
  • point-of-care biosensors

Published Papers (2 papers)

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Research

15 pages, 2879 KiB  
Article
A Methylene Blue-Enhanced Nanostructured Electrochemical Immunosensor for H-FABP Myocardial Injury Biomarker
by
Cecília Maciel Prado
,
Paula Angélica Burgos Ferreira
,
Lucas Alves de Lima
,
Erika Ketlem Gomes Trindade
and
Rosa Fireman Dutra
Biosensors 2023, 13(9), 873; https://doi.org/10.3390/bios13090873 - 07 Sep 2023
Viewed by 687
Abstract
A sensitive electrochemical immunosensor for the detection of the heart-type fatty acid binding protein (HFABP), an earlier biomarker for acute myocardial infarction than Troponins, is described. The sensing platform was enhanced with methylene blue (MB) redox coupled to carbon nanotubes (CNT) assembled on [...] Read more.
A sensitive electrochemical immunosensor for the detection of the heart-type fatty acid binding protein (HFABP), an earlier biomarker for acute myocardial infarction than Troponins, is described. The sensing platform was enhanced with methylene blue (MB) redox coupled to carbon nanotubes (CNT) assembled on a polymer film of polythionine (PTh). For this strategy, monomers of thionine rich in amine groups were electrosynthesized by cyclic voltammetry on the immunosensor’s gold surface, forming an electroactive film with excellent electron transfer capacity. Stepwise sensor surface preparation was electrochemically characterized at each step and scanning electronic microscopy was carried out showing all the preparation steps. The assembled sensor platform combines MB and PTh in a synergism, allowing sensitive detection of the H-FABP in a linear response from 3.0 to 25.0 ng∙mL−1 with a limit of detection of 1.47 ng∙mL−1 HFABP that is similar to the clinical level range for diagnostics. H-FABP is a newer powerful biomarker for distinguishing between unstable angina and acute myocardial infarction. Full article
(This article belongs to the Special Issue Nanomaterial Based Biosensors for Biomedical Applications)
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12 pages, 3436 KiB  
Article
Cobalt–Nitrogen Co-Doped Carbon as Highly Efficient Oxidase Mimics for Colorimetric Assay of Nitrite
by
Dalei Lin
,
Shuzhi Wu
,
Shushu Chu
and
Yizhong Lu
Biosensors 2023, 13(7), 748; https://doi.org/10.3390/bios13070748 - 20 Jul 2023
Viewed by 641
Abstract
Transition metal-N-doped carbon has been demonstrated to mimic natural enzyme activity; in this study, cobalt–nitrogen co-doped carbon (Co-N-C) nanomaterial was developed, and it could be an oxidase mimic. Firstly, Co-N-C with oxidase-like activity boosts the chromogenic reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce the [...] Read more.
Transition metal-N-doped carbon has been demonstrated to mimic natural enzyme activity; in this study, cobalt–nitrogen co-doped carbon (Co-N-C) nanomaterial was developed, and it could be an oxidase mimic. Firstly, Co-N-C with oxidase-like activity boosts the chromogenic reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce the oxidized TMB (oxTMB). And the aromatic primary amino group of oxTMB reacts with nitrite (NO2−) to form diazo groups. Based on this background, we developed a cascade system of a Co-N-C-catalyzed oxidation reaction and a diazotization reaction for nitrite determination. The low detection limit (0.039 μM) indicates that Co-N-C is superior compared with the vast majority of previously reported nitrite assays. This study not only provides a novel nanozyme with sufficiently dispersed active sites, but it also further applies it to the determination of nitrite, which is expected to expand the application of nanozymes in colorimetric analysis. Full article
(This article belongs to the Special Issue Nanomaterial Based Biosensors for Biomedical Applications)
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