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Biosensors
Special Issues
Nanoprobes for Biomedical Applications
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Nanoprobes for Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 6399

Special Issue Editor

Prof. Dr. Zheyu Shen

E-Mail Website
Guest Editor
School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China
Interests: MRI contrast agents; tumor ferroptosis therapy; nanomaterials; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of Nanoprobes for Biomedical Applications, including tumor diagnosis, tumor therapy, molecular imaging, drug/gene delivery, and tissue engineering, is a research hotspot that is growing fast. Its development has been leading to the the transformation of many new technologies in clinical applications. Consequently, to serve the growing scientific community, there is an urgent need to publish a Special Issue on “Nanoprobes for Biomedical Applications”. This Special Issue aims to provide a exchange platform for various research communities of materials science, chemistry, pharmacology, medicine, oncology, biology, and biomedical engineering to promote the biomedical application of nanoprobes. This Special Issue mainly publishes editorials, reviews, and research articles. The scope includes but is not limited to nanoprobes, nanomaterials, tumor theranostics, drug/gene delivery, magnetic resonance imaging contrast agents, photoacoustic imaging, fluorescence imaging, immunotherapy, ferroptosis therapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, heavy ion therapy, gas therapy, synergistic treatment, tissue engineering, and circulating tumor cells.

Prof. Dr. Zheyu Shen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoprobes
  • tumor diagnosis
  • tumor therapy
  • molecular imaging
  • drug/gene delivery
  • tissue engineering

Published Papers (4 papers)

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Research

12 pages, 4716 KiB  
Communication
A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide
by Yulei Li, Chen Zhou, Jiaxin Li and Jing Sun
Biosensors 2024, 14(1), 51; https://doi.org/10.3390/bios14010051 - 18 Jan 2024
Viewed by 1211
Abstract
A new fluorescent sensor for the detection of CN− was developed based on the conjugation of phenothiazine fluorophore and benzofuran unit. By the nucleophilic attacking of CN− to the fluoroacetylamino group in the sensor, the additional reaction of CN− and [...] Read more.
A new fluorescent sensor for the detection of CN− was developed based on the conjugation of phenothiazine fluorophore and benzofuran unit. By the nucleophilic attacking of CN− to the fluoroacetylamino group in the sensor, the additional reaction of CN− and carbonyl group induced the ICT (intramolecular charge transfer) effect in the molecule and caused the fluorescence quenching sensor. The titration experiments show that the sensor has good sensitivity, selectivity and quick response for CN−. In addition, the fluorescent detection of CN− in the living cell and zebrafish experiments demonstrated the value of the sensor in tracing the CN− in biological systems. Full article
(This article belongs to the Special Issue Nanoprobes for Biomedical Applications)
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15 pages, 3170 KiB  
Article
Cascade Amplified Plasmonics Molecular Biosensor for Sensitive Detection of Disease Biomarkers
by Hsin-Neng Wang and Tuan Vo-Dinh
Biosensors 2023, 13(8), 774; https://doi.org/10.3390/bios13080774 - 31 Jul 2023
Viewed by 1094
Abstract
Recent advances in molecular technologies have provided various assay strategies for monitoring biomarkers, such as miRNAs for early detection of various diseases and cancers. However, there is still an urgent unmet need to develop practical and accurate miRNA analytical tools that could facilitate [...] Read more.
Recent advances in molecular technologies have provided various assay strategies for monitoring biomarkers, such as miRNAs for early detection of various diseases and cancers. However, there is still an urgent unmet need to develop practical and accurate miRNA analytical tools that could facilitate the incorporation of miRNA biomarkers into clinical practice and management. In this study, we demonstrate the feasibility of using a cascade amplification method, referred to as the “Cascade Amplification by Recycling Trigger Probe” (CARTP) strategy, to improve the detection sensitivity of the inverse Molecular Sentinel (iMS) nanobiosensor. The iMS nanobiosensor developed in our laboratory is a unique homogeneous multiplex bioassay technique based on surface-enhanced Raman scattering (SERS) detection, and was used to successfully detect miRNAs from clinical samples. The CARTP strategy based on the toehold-mediated strand displacement reaction is triggered by a linear DNA strand, called the “Recycling Trigger Probe” (RTP) strand, to amplify the iMS SERS signal. Herein, by using the CARTP strategy, we show a significantly improved detection sensitivity with the limit of detection (LOD) of 45 fM, which is 100-fold more sensitive than the non-amplified iMS assay used in our previous report. We envision that the further development and optimization of this strategy ultimately will allow multiplexed detection of miRNA biomarkers with ultra-high sensitivity for clinical translation and application. Full article
(This article belongs to the Special Issue Nanoprobes for Biomedical Applications)
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16 pages, 14515 KiB  
Article
Conductive Nanofibers-Enhanced Microfluidic Device for the Efficient Capture and Electrical Stimulation-Triggered Rapid Release of Circulating Tumor Cells
by Yisha Huang, Xilin Li, Jianwen Hou, Zhouying Luo, Guang Yang and Shaobing Zhou
Biosensors 2023, 13(5), 497; https://doi.org/10.3390/bios13050497 - 25 Apr 2023
Viewed by 1378
Abstract
The effective detection and release of circulating tumor cells (CTCs) are of great significance for cancer diagnosis and monitoring. The microfluidic technique has proved to be a promising method for CTCs isolation and subsequent analysis. However, complex micro-geometries or nanostructures were often constructed [...] Read more.
The effective detection and release of circulating tumor cells (CTCs) are of great significance for cancer diagnosis and monitoring. The microfluidic technique has proved to be a promising method for CTCs isolation and subsequent analysis. However, complex micro-geometries or nanostructures were often constructed and functionalized to improve the capture efficiency, which limited the scale-up for high-throughput production and larger-scale clinical applications. Thus, we designed a simple conductive nanofiber chip (CNF-Chip)-embedded microfluidic device with a herringbone microchannel to achieve the efficient and specific capture and electrical stimulation-triggered rapid release of CTCs. Here, the most used epithelial cell adhesion molecule (EpCAM) was selected as the representative biomarker, and the EpCAM-positive cancer cells were mainly studied. Under the effects of the nanointerface formed by the nanofibers with a rough surface and the herringbone-based high-throughput microfluidic mixing, the local topographic interaction between target cells and nanofibrous substrate in the microfluidic was synergistically enhanced, and the capture efficiency for CTCs was further improved (more than 85%). After capture, the sensitive and rapid release of CTCs (release efficiency above 97%) could be conveniently achieved through the cleavage of the gold-sulfur bond by applying a low voltage (−1.2 V). The device was successfully used for the effective isolation of CTCs in clinical blood samples from cancer patients, indicating the great potential of this CNF-Chip-embedded microfluidic device in clinical applications. Full article
(This article belongs to the Special Issue Nanoprobes for Biomedical Applications)
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11 pages, 2732 KiB  
Article
Enhanced Therapeutic Potential of Irreversible Electroporation under Combination with Gold-Doped Mesoporous Silica Nanoparticles against EMT-6 Breast Cancer Cells
by Yixin Jiang, Ratchapol Jenjob and Su-Geun Yang
Biosensors 2023, 13(1), 41; https://doi.org/10.3390/bios13010041 - 27 Dec 2022
Cited by 2 | Viewed by 2012
Abstract
Irreversible electroporation (IRE) is a non-thermal tumor ablation technique that delivers short pulses of strong electric fields to cancer tissues and induces cell death through the destruction of cell membranes. Here, we synthesized gold-doped mesoporous silica nanoparticles (Au-MSNs) via incipient wetness impregnation and [...] Read more.
Irreversible electroporation (IRE) is a non-thermal tumor ablation technique that delivers short pulses of strong electric fields to cancer tissues and induces cell death through the destruction of cell membranes. Here, we synthesized gold-doped mesoporous silica nanoparticles (Au-MSNs) via incipient wetness impregnation and evaluated the therapeutic potentials of combination therapy with IRE. The fabricated Au-MSNs had around 80–100 nm of particle size and were successfully end-doped with Au nanoparticles. Combination treatment of IRE (800 V/cm) and Au-MSNs (100 μg/mL) increased cell membrane permeability by 25-fold compared with single IRE treatment. Cellular reactive oxygen species (ROS) and lipid peroxidation of EMT-6 cells were significantly increased by 14- and 265-fold, respectively, under combination treatment of IRE (800 V/cm) and Au-MSNs (100 µg/mL). Cytotoxic cell death increased by 28% under a combination treatment of IRE (800 V/cm) and Au-MSNs (100 ug/mL) over single IRE. Our studies suggest that the combination treatment of IRE with Au-MSNs can enhance the therapeutic efficacy of IRE for breast cancer. Full article
(This article belongs to the Special Issue Nanoprobes for Biomedical Applications)
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