Lab-on-a-Chip Devices for Point-of-Care Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1713

Special Issue Editors


E-Mail Website
Guest Editor
National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA
Interests: biosensors; organ-on-a-chip; electrochemistry; semiconductor physics and devices; microfabrication

E-Mail Website
Guest Editor
Nanobioelectronics Laboratory, Department of Biomedical Engineering, Ben‐Gurion University of the Negev, Beer‐Sheva 8410501, Israel
Interests: BioMEMS; biosensors; electrochemistry; lab-on-a-chip; microfabrication; bioelectronics

Special Issue Information

Dear Colleagues,

Lab-on-a-chip (LOC) devices have emerged as new tools to model disease, assess therapeutic efficacy, screen potentially toxic drugs, and monitor health. Given their reduced spatial footprint, LOC devices are particularly well-suited for point-of-care (POC) diagnostic applications, which often require portability, prompt results, and simple, user-friendly operation. In light of this rapidly growing area of research, we are pleased to invite you to contribute to this Special Issue focused on recent advances, current challenges, and future perspectives for the development of lab-on-a-chip devices and their application in point-of-care diagnostics.

This Special Issue is devoted to advancements in all aspects of lab-on-a-chip devices targeting point-of-care diagnostic applications, including, but not limited to, new device architectures and fabrication methods, sample preparation and sorting strategies, analytical techniques and capabilities, applications (e.g., multi-functional devices for diagnosis and treatment), and sensor design and development. These can be applied to a range of analytes and markers of interest at the point-of-care, including, but not limited to, small molecules, metabolites, microbes, mammalian cells, proteins, nucleic acids, and ions.

This Special issue aims to focus on the most recent developments in the area of lab-on-a-chip devices for point-of-care applications and will consist of research articles, short communications, review articles, and perspectives.

We are excited to work with you and look forward to your submission.

Dr. Derrick Butler
Dr. Hadar Ben-Yoav
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab-on-a-chip
  • point-of-care
  • diagnostics
  • biosensor
  • organ-on-a-chip
  • microphysiological systems

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 3737 KiB  
Article
Development of a Quantitative Digital Urinalysis Tool for Detection of Nitrite, Protein, Creatinine, and pH
by Vince S. Siu, Minhua Lu, Kuan Yu Hsieh, Bo Wen, Italo Buleje, Nigel Hinds, Krishna Patel, Bing Dang and Russell Budd
Biosensors 2024, 14(2), 70; https://doi.org/10.3390/bios14020070 - 30 Jan 2024
Viewed by 1352
Abstract
This paper presents a cost-effective, quantitative, point-of-care solution for urinalysis screening, specifically targeting nitrite, protein, creatinine, and pH in urine samples. Detecting nitrite is crucial for the early identification of urinary tract infections (UTIs), while regularly measuring urinary protein-to-creatinine (UPC) ratios aids in [...] Read more.
This paper presents a cost-effective, quantitative, point-of-care solution for urinalysis screening, specifically targeting nitrite, protein, creatinine, and pH in urine samples. Detecting nitrite is crucial for the early identification of urinary tract infections (UTIs), while regularly measuring urinary protein-to-creatinine (UPC) ratios aids in managing kidney health. To address these needs, we developed a portable, transmission-based colorimeter using readily available components, controllable via a smartphone application through Bluetooth. Multiple colorimetric detection strategies for each analyte were identified and tested for sensitivity, specificity, and stability in a salt buffer, artificial urine, and human urine. The colorimeter successfully detected all analytes within their clinically relevant ranges: nitrite (6.25–200 µM), protein (2–1024 mg/dL), creatinine (2–1024 mg/dL), and pH (5.0–8.0). The introduction of quantitative protein and creatinine detection, and a calculated urinary protein-to-creatinine (UPC) ratio at the point-of-care, represents a significant advancement, allowing patients with proteinuria to monitor their condition without frequent lab visits. Furthermore, the colorimeter provides versatile data storage options, facilitating local storage on mobile devices or in the cloud. The paper further details the setup of the colorimeter’s secure connection to a cloud-based environment, and the visualization of time-series analyte measurements in a web-based dashboard. Full article
(This article belongs to the Special Issue Lab-on-a-Chip Devices for Point-of-Care Diagnostics)
Show Figures

Figure 1

Back to TopTop