Biosensors Based on Two-Dimensional Materials

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 9521

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Laboratory of Nanoelectronics, Graphene and 2D materialsDepartment of Electronics and Computer Technology, University of Granada, 18071 Granada, Spain
Interests: advanced device simulation; device characterization; CMOS co-integration; 2D materials; biosensors
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anglaisLaboratoire des Matériaux et du Génie Physique, University Grenoble Alpes, F-38000 Grenoble, France
Interests: transistors; force-sensing device

Special Issue Information

Dear Colleagues,

In 1985, the world market for biosensors was estimated at USD 5 million. Today, it exceeds the figure of USD 28,000 million. This extraordinary success is undoubtedly due to the strategic nature of their use, resulting from the combination of basic research with the eminently practical objective of generating wealth and improving the quality of life. An additional attraction for biosensor research lies in its multidisciplinary nature, that demands not only experience in chemistry, physics, biology, or engineering but also deep knowledge in the areas where biosensors are applied: in pharmaceutical fields, environmental and food control, as well as clinics and healthcare. Related with the latter, the early diagnosis of any disease is a key element that determines the success of its treatment and cure. Being able to conduct rapid and reliable analytic tests at a very low cost would allow widespread and early diagnosis to be possible for the general population, thus contributing to the globalization of healthcare. Two-dimensional materials could be the missing link in the chain that would allow this dream to become a reality within a short period of time: recent results show that biosensors based on two-dimensional materials could make analytical results available at the patient’s bedside or a physician’s office within few minutes, all for a low cost and with very low limits of detection. The nanosized nature of nanomaterials and their unique chemical and electrical properties can improve patient care by making the sensors minimally invasive and extremely sensitive and, at the time, amenable to high-throughput screening, real-time analysis, and label-free detection together with a low limit of detection (LOD) and low sample volume requirements for analysis. This Special Issue is dedicated to the advanced and emerging concepts and technologies of bioelectric sensors based on two-dimensional materials. Topics include, but are not restricted to, electrochemical sensors, optical sensors, and field effect transistor methods. Also of interest are innovative approaches offering a high-throughput analytical capacity, point-of-care/portable and wireless instrumentation, and intelligent bioelectric sensing platforms. Research papers, short communications, and reviews are all welcome.

Prof. Dr. Francisco Gamiz
Dr. Mireille Mouis
Guest Editors

Manuscript Submission Information

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Published Papers (1 paper)

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26 pages, 6740 KiB  
Review
Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis
by Samir Kamel and Tawfik A. Khattab
Biosensors 2020, 10(6), 67; https://doi.org/10.3390/bios10060067 - 17 Jun 2020
Cited by 106 | Viewed by 9190
Abstract
Cellulose has attracted much interest, particularly in medical applications such as advanced biosensing devices. Cellulose could provide biosensors with enhanced biocompatibility, biodegradability and non-toxicity, which could be useful for biosensors. Thus, they play a significant role in environmental monitoring, medical diagnostic tools, forensic [...] Read more.
Cellulose has attracted much interest, particularly in medical applications such as advanced biosensing devices. Cellulose could provide biosensors with enhanced biocompatibility, biodegradability and non-toxicity, which could be useful for biosensors. Thus, they play a significant role in environmental monitoring, medical diagnostic tools, forensic science, and foodstuff processing safety applications. This review summarizes the recent developments in cellulose-based biosensors targeting the molecular design principles toward medical detection purposes. The recognition/detection mechanisms of cellulose-based biosensors demonstrate two major classes of measurable signal generation, including optical and electrochemical cellulosic biosensors. As a result of their simplicity, high sensitivity, and low cost, cellulose-based optical biosensors are particularly of great interest for including label-free and label-driven (fluorescent and colorimetric) biosensors. There have been numerous types of cellulose substrates employed in biosensors, including several cellulose derivatives, nano-cellulose, bacterial cellulose, paper, gauzes, and hydrogels. These kinds of cellulose-based biosensors were discussed according to their preparation procedures and detection principle. Cellulose and its derivatives with their distinctive chemical structure have demonstrated to be versatile materials, affording a high-quality platform for accomplishing the immobilization process of biologically active molecules into biosensors. Cellulose-based biosensors exhibit a variety of desirable characteristics, such as sensitivity, accuracy, convenience, quick response, and low-cost. For instance, cellulose paper-based biosensors are characterized as being low-cost and easy to operate, while nano-cellulose biosensors are characterized as having a good dispersion, high absorbance capacity, and large surface area. Cellulose and its derivatives have been promising materials in biosensors which could be employed to monitor various bio-molecules, such as urea, glucose, cell, amino acid, protein, lactate, hydroquinone, gene, and cholesterol. The future interest will focus on the design and construction of multifunctional, miniaturized, low-cost, environmentally friendly, and integrated biosensors. Thus, the production of cellulose-based biosensors is very important. Full article
(This article belongs to the Special Issue Biosensors Based on Two-Dimensional Materials)
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