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Biosensors for the Analysis and Detection of Drug, Food or...
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Biosensors for the Analysis and Detection of Drug, Food or Disease

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4188

Special Issue Editors

Prof. Dr. Lingwen Zeng

E-Mail Website
Guest Editor
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Interests: novel diagnostic technologies for human diseases; food and environmental safety
Dr. Junhua Chen

E-Mail Website
Guest Editor
Guangdong Institute of Eco-Environment and Soil Science, Guangzhou, China
Interests: environmental quality and food safety

Special Issue Information

Dear Colleagues,

Burgeoning biosensor technology offers an excellent analytical platform for the rapid, low-cost, portable, and on-site detection of various analytes. Using bioreceptors as the molecular recognition elements, biosensors can recognize a specific analyte based on different mechanisms, such as aptamer-target binding, nucleic acid hybridization, antigen-antibody recognition, enzyme inhibition, and enzyme-mimicking activity. There are many hazardous substances in drug, food, environmental, and biological samples, such as heavy metals, mycotoxins, pesticides, food-borne pathogens, narcotic drugs, veterinary drugs, illegal additives, persistent organic pollutants, and biomarkers of infectious diseases. In recent years, some exquisite biosensors have been developed for the detection of these analytes, including fluorescent, electrochemical, colorimetric, electrochemiluminescent, and lateral flow strip methods. The challenge is how to improve the detection sensitivity and specificity when confronted with complex practical samples. At the same time, on-site analysis has attracted more and more attention in recent years, since it can provide qualitative or/and quantitative information of samples. The realization of on-site analysis largely depends on instruments and sample preparation technologies. Thus, the development of portable instruments for on-site analysis of contaminants in real samples is highly desirable.

This Special Issue is soliciting original articles and reviews on “Biosensors for the Analysis and Detection of Drug, Food or Disease”, mainly focusing on novel analytical methods, biosensors, and portable instruments for the detection of contaminants and biomarkers in drug, food, environmental, and biological samples. We would like to invite you to submit your manuscript to us.

Prof. Dr. Lingwen Zeng
Dr. Junhua Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensor
  • heavy metal
  • mycotoxin
  • pesticide
  • biomarker
  • drug
  • aptamer
  • rapid detection
  • on-site analysis
  • portable instrument

Published Papers (3 papers)

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Research

13 pages, 2355 KiB  
Article
Enhanced Nanozymatic Activity on Rough Surfaces for H2O2 and Tetracycline Detection
by Tawfiq Alsulami and Abdulhakeem Alzahrani
Biosensors 2024, 14(2), 106; https://doi.org/10.3390/bios14020106 - 17 Feb 2024
Cited by 1 | Viewed by 1120
Abstract
The needless use of tetracyclines (TCs) in foodstuffs is a huge health concern in low- and middle-income and Arab countries. Herein, a sensitive and faster monitoring system for H2O2 and TCs is proposed, utilizing the large surface-to-volume ratio of a [...] Read more.
The needless use of tetracyclines (TCs) in foodstuffs is a huge health concern in low- and middle-income and Arab countries. Herein, a sensitive and faster monitoring system for H2O2 and TCs is proposed, utilizing the large surface-to-volume ratio of a non-spherical gold nanoparticle/black phosphorus nanocomposite (BP-nsAu NPs) for the first time. BP-nsAu NPs were synthesized through a single-step method that presented nanozymatic activity through 3,3′,5,5′-Tetramethylbenzidine (TMB) oxidation while H2O2 was present and obeyed the Michaelis–Menten equation. The nanozymatic activity of the BP-nsAu NPs was enhanced 12-fold and their detection time was decreased 83-fold compared to conventional nanozymatic reactions. The proposed method enabled us to quantify H2O2 with a limit of detection (LOD) value of 60 nM. Moreover, target-specific aptamer-conjugated BP-nsAu NPs helped us detect TCs with an LOD value of 90 nM. The present strategy provides a proficient route for low-level TC monitoring in real samples. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food or Disease)
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13 pages, 6602 KiB  
Article
Lateral Flow Biosensor for On-Site Multiplex Detection of Viruses Based on One-Step Reverse Transcription and Strand Displacement Amplification
by Xuewen Lu, Kangning Ding, Zhiyuan Fang, Yilei Liu, Tianxing Ji, Jian Sun, Zhenling Zeng and Limin He
Biosensors 2024, 14(2), 103; https://doi.org/10.3390/bios14020103 - 17 Feb 2024
Viewed by 1183
Abstract
Respiratory pathogens pose a huge threat to public health, especially the highly mutant RNA viruses. Therefore, reliable, on-site, rapid diagnosis of such pathogens is an urgent need. Traditional assays such as nucleic acid amplification tests (NAATs) have good sensitivity and specificity, but these [...] Read more.
Respiratory pathogens pose a huge threat to public health, especially the highly mutant RNA viruses. Therefore, reliable, on-site, rapid diagnosis of such pathogens is an urgent need. Traditional assays such as nucleic acid amplification tests (NAATs) have good sensitivity and specificity, but these assays require complex sample pre-treatment and a long test time. Herein, we present an on-site biosensor for rapid and multiplex detection of RNA pathogens. Samples with viruses are first lysed in a lysis buffer containing carrier RNA to release the target RNAs. Then, the lysate is used for amplification by one-step reverse transcription and single-direction isothermal strand displacement amplification (SDA). The yield single-strand DNAs (ssDNAs) are visually detected by a lateral flow biosensor. With a secondary signal amplification system, as low as 20 copies/μL of virus can be detected in this study. This assay avoids the process of nucleic acid purification, making it equipment-independent and easier to operate, so it is more suitable for on-site molecular diagnostic applications. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food or Disease)
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13 pages, 2662 KiB  
Article
The Development of Reagentless Amperometric Glucose Biosensor Based on Gold Nanostructures, Prussian Blue and Glucose Oxidase
by Laura Sakalauskiene, Benediktas Brasiunas, Anton Popov, Asta Kausaite-Minkstimiene and Almira Ramanaviciene
Biosensors 2023, 13(10), 942; https://doi.org/10.3390/bios13100942 - 20 Oct 2023
Cited by 1 | Viewed by 1540
Abstract
Precise blood glucose detection plays a crucial role in diagnosing and medicating diabetes, in addition to aiding diabetic patients in effectively managing their condition. In this research, a first-generation reagentless amperometric glucose biosensor was developed by combining the graphite rod (GR) electrode modification [...] Read more.
Precise blood glucose detection plays a crucial role in diagnosing and medicating diabetes, in addition to aiding diabetic patients in effectively managing their condition. In this research, a first-generation reagentless amperometric glucose biosensor was developed by combining the graphite rod (GR) electrode modification by gold nanostructures (AuNS) and Prussian blue (PB) with glucose oxidase (GOx)—an enzyme that can oxidize glucose and produce H2O2. Firstly, AuNS was electrochemically deposited on the GR electrode (AuNS/GR), and then PB was electrochemically synthesized on the AuNS/GR electrode (PB/AuNS/GR). Finally, GOx was immobilized over the PB/AuNS nanocomposite with the assistance of Nafion (Nf) (Nf-GOx/PB/AuNS/GR). An application of PB in the design of a glucose biosensor enables an easy electrochemical reduction and, thus, the determination of the H2O2 produced during the GOx-catalyzed oxidation of glucose in the sample at a low operation potential of −0.05 V vs. Ag/AgCl/KCl3 mol L−1. In addition, AuNS increased the electrochemically active surface area, improved the GOx immobilization and ensured a higher analytical signal. The developed glucose biosensor based on the Nf-GOx/PB/AuNS/GR electrode exhibited a wide linear range, from 0.025 to 1 mmol L−1 of glucose, with a 0.0088 mmol L−1 limit of detection, good repeatability and high selectivity over electroactive interfering substances. The developed biosensor is convenient for the determination of glucose in the physiological environment. Full article
(This article belongs to the Special Issue Biosensors for the Analysis and Detection of Drug, Food or Disease)
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