Organic Bioelectronic Materials and Devices for Biosensing Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 6743

Special Issue Editors


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Guest Editor
Professorship of Material Systems for Nanoelectronics, Faculty of Electrical Engineering and Information Technology, Chemnitz University of Technology, 09126 Chemnitz, Germany
Interests: organic bioelectronics; organic electronic devices; organic semiconductors; charge transport mechanisms
Special Issues, Collections and Topics in MDPI journals
Center for Sensors and Devices, Bruno Kessler Foundation (FBK), 38123 Trento, Italy
Interests: organic bioelectronics; organic fied-effect transistors; device physics; semiconductor devices; thin-film processing; micro/nano-fabrication
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As a field, organic bioelectronics focuses on the development and investigation of organic electronic devices that translate biological signals into an electronic readout. Organic bioelectronics allows us to regulate the physiology and processes of cells, tissues, and organs, while it can also be applied for the selective sensing, recording, and monitoring of various signals and physiological states.

In order to bridge the interface between biology and electronics, an important aspect involves the advancement of materials, which, in turn, enables better performing bioelectronic devices or entirely new device concepts. The existing bioelectronic devices mostly compose of conventional materials, such as metals, that do not exhibit intrinsic compatibility with biological systems and are unable to convert biological ionic signals into electronic ones. The structural and functional similarity between organic and biological systems creates many new possibilities in areas spanning from neural interfacing and drug delivery to tissue engineering and diagnostics. Among other unique features, organic materials and devices offer "soft" mechanical properties, mixed electronic/ionic conductivity for efficient signal transduction, facile functionalization for the detection of biological analytes, and economical synthesis. All of the aforementioned aspects, in addition to better biocompatibility and biodegradability, makes organic systems more suitable for biomedical applications.

This Special Issue aims to share new developments and challenges in the growing field of bioelectronics. We invite authors to contribute articles that will stimulate the development of novel bioelectronic materials or devices, or help to optimize the performance of already available technologies.

The topics of interest include, but are not limited to:

- Materials for in vitro and in vivo organic bioelectronics;

- Devices for in vitro and in vivo organic bioelectronics;

- Tailoring bio-interfaces for in vitro and in vivo applications;

- Modeling in vitro and in vivo organic bioelectronics applications;

- Cell-based interfacing for in vitro and in vivo organic bioelectronics;

- Fluidic-integrated models for in vitro and in vivo organic bioelectronic systems.

Dr. Leandro Merces
Dr. Ali Nawaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioelectronic devices
  • biosensing
  • materials
  • biointerfaces
  • neural interfacing
  • drug delivery
  • tissue engineering
  • diagnostics

Published Papers (3 papers)

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Research

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21 pages, 3152 KiB  
Article
Gram-Positive Bacterial Membrane-Based Biosensor for Multimodal Investigation of Membrane–Antibiotic Interactions
by Samavi Farnush Bint-E-Naser, Zeinab Jushkun Mohamed, Zhongmou Chao, Karan Bali, Róisín M. Owens and Susan Daniel
Biosensors 2024, 14(1), 45; https://doi.org/10.3390/bios14010045 - 15 Jan 2024
Viewed by 1637
Abstract
As membrane-mediated antibiotic resistance continues to evolve in Gram-positive bacteria, the development of new approaches to elucidate the membrane properties involved in antibiotic resistance has become critical. Membrane vesicles (MVs) secreted by the cytoplasmic membrane of Gram-positive bacteria contain native components, preserving lipid [...] Read more.
As membrane-mediated antibiotic resistance continues to evolve in Gram-positive bacteria, the development of new approaches to elucidate the membrane properties involved in antibiotic resistance has become critical. Membrane vesicles (MVs) secreted by the cytoplasmic membrane of Gram-positive bacteria contain native components, preserving lipid and protein diversity, nucleic acids, and sometimes virulence factors. Thus, MV-derived membrane platforms present a great model for Gram-positive bacterial membranes. In this work, we report the development of a planar bacterial cytoplasmic membrane-based biosensor using MVs isolated from the Bacillus subtilis WT strain that can be coated on multiple surface types such as glass, quartz crystals, and polymeric electrodes, fostering the multimodal assessment of drug–membrane interactions. Retention of native membrane components such as lipoteichoic acids, lipids, and proteins is verified. This biosensor replicates known interaction patterns of the antimicrobial compound, daptomycin, with the Gram-positive bacterial membrane, establishing the applicability of this platform for carrying out biophysical characterization of the interactions of membrane-acting antibiotic compounds with the bacterial cytoplasmic membrane. We report changes in membrane viscoelasticity and permeability that correspond to partial membrane disruption when calcium ions are present with daptomycin but not when these ions are absent. This biomembrane-based biosensing platform enables an assessment of membrane biophysical characteristics during exposure to antibiotic drug candidates to aid in identifying compounds that target membrane disruption as a mechanism of action. Full article
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Review

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37 pages, 5678 KiB  
Review
Aptamers and Nanobodies as New Bioprobes for SARS-CoV-2 Diagnostic and Therapeutic System Applications
by Ki Sung Park, Tae-In Park, Jae Eon Lee, Seo-Yeong Hwang, Anna Choi and Seung Pil Pack
Biosensors 2024, 14(3), 146; https://doi.org/10.3390/bios14030146 - 15 Mar 2024
Viewed by 1097
Abstract
The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored the critical importance of innovative and efficient control systems for addressing future pandemics. The most effective way to control the pandemic is to rapidly suppress the spread [...] Read more.
The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored the critical importance of innovative and efficient control systems for addressing future pandemics. The most effective way to control the pandemic is to rapidly suppress the spread of the virus through early detection using a rapid, accurate, and easy-to-use diagnostic platform. In biosensors that use bioprobes, the binding affinity of molecular recognition elements (MREs) is the primary factor determining the dynamic range of the sensing platform. Furthermore, the sensitivity relies mainly on bioprobe quality with sufficient functionality. This comprehensive review investigates aptamers and nanobodies recently developed as advanced MREs for SARS-CoV-2 diagnostic and therapeutic applications. These bioprobes might be integrated into organic bioelectronic materials and devices, with promising enhanced sensitivity and specificity. This review offers valuable insights into advancing biosensing technologies for infectious disease diagnosis and treatment using aptamers and nanobodies as new bioprobes. Full article
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48 pages, 26051 KiB  
Review
Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications
by Jyoti Bala Kaushal, Pratima Raut and Sanjay Kumar
Biosensors 2023, 13(11), 976; https://doi.org/10.3390/bios13110976 - 07 Nov 2023
Cited by 4 | Viewed by 3460
Abstract
The promising field of organic electronics has ushered in a new era of biosensing technology, thus offering a promising frontier for applications in both medical diagnostics and environmental monitoring. This review paper provides a comprehensive overview of organic electronics’ remarkable progress and potential [...] Read more.
The promising field of organic electronics has ushered in a new era of biosensing technology, thus offering a promising frontier for applications in both medical diagnostics and environmental monitoring. This review paper provides a comprehensive overview of organic electronics’ remarkable progress and potential in biosensing applications. It explores the multifaceted aspects of organic materials and devices, thereby highlighting their unique advantages, such as flexibility, biocompatibility, and low-cost fabrication. The paper delves into the diverse range of biosensors enabled by organic electronics, including electrochemical, optical, piezoelectric, and thermal sensors, thus showcasing their versatility in detecting biomolecules, pathogens, and environmental pollutants. Furthermore, integrating organic biosensors into wearable devices and the Internet of Things (IoT) ecosystem is discussed, wherein they offer real-time, remote, and personalized monitoring solutions. The review also addresses the current challenges and future prospects of organic biosensing, thus emphasizing the potential for breakthroughs in personalized medicine, environmental sustainability, and the advancement of human health and well-being. Full article
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