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Biomimetics
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Advances in Bioceramics for Bone Regeneration
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Advances in Bioceramics for Bone Regeneration

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 5069

Special Issue Editors

Prof. Dr. Mihai Valentin Predoi

E-Mail Website
Guest Editor
Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania
Interests: numerical simulation of ultrasound propagation; nondestructive ultrasonic technique for biomaterials; sound propagation simulation; nonlinear vibrations; plate vibrations; vibrations in aeronautical structures; finite elements analysis
Dr. Simona Liliana Iconaru

E-Mail Website
Guest Editor
National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
Interests: biomaterials; biomedical applications; environmental applications; surface analysis; antimicrobial properties
Special Issues, Collections and Topics in MDPI journals
Dr. Carmen Steluta Ciobanu

E-Mail Website
Guest Editor
National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
Interests: biomaterials; nanoparticles; hydroxyapatite; biomedical applications; physico-chemical properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A biomaterial is a material designed to interact with biological systems for either therapeutic or medical diagnostic purposes. Various biomaterials have been developed for use as synthetic bone graft substitutes, ranging from metals to polymers. However, bioceramics remain the most used material. Furthermore, calcium orthophosphates (CaP), due to their similarity to the mineral phase of bone, are the most widely used. Hydroxyapatite (HAp) is the only CaP that can be obtained both by precipitation in aqueous systems at low temperature and by reaction in the solid state. HAp represents approximately 65% of the weight of bone tissue, but the properties of bone are not only explained by its composition, but also by its complex structure.

In this Special Issue, we aim to bring together interdisciplinary studies focused on research on recent advances in the creation of innovative and functional nanostructured materials that could be used in bone generation.

Prof. Dr. Mihai Valentin Predoi
Dr. Simona Liliana Iconaru
Dr. Carmen Steluta Ciobanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydroxyapatite
  • calcium phosphate
  • biomaterials
  • bioceramics
  • bone regeneration

Published Papers (5 papers)

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Research

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17 pages, 20940 KiB  
Article
Strontium and Copper Co-Doped Multifunctional Calcium Phosphates: Biomimetic and Antibacterial Materials for Bone Implants
by Vladimir N. Lebedev, Mariya I. Kharovskaya, Bogdan I. Lazoryak, Anastasiya O. Solovieva, Inna V. Fadeeva, Abdulkarim A. Amirov, Maksim A. Koliushenkov, Farid F. Orudzhev, Oksana V. Baryshnikova, Viktoriya G. Yankova, Julietta V. Rau and Dina V. Deyneko
Biomimetics 2024, 9(4), 252; https://doi.org/10.3390/biomimetics9040252 - 20 Apr 2024
Viewed by 743
Abstract
β-tricalcium phosphate (β-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that doping the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped β-TCP, [...] Read more.
β-tricalcium phosphate (β-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that doping the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped β-TCP, that is explained by their ability, on the one hand, to reduce cytotoxicity for cells of the human organism, on the other hand, to achieve a successful antibacterial effect. Sr, Cu-co-doped solid solutions of the composition Ca9.5–xSrxCu(PO4)7 was obtained by the method of solid-phase reactions. The Rietveld method of structural refinement revealed the presence of Sr2+ ions in four crystal sites: M1, M2, M3, and M4. The M5 site is completely occupied by Cu2+. Isomorphic substitution of Ca2+ → (Sr2+and Cu2+) expands the concentration limits of the existence of the solid solution with the β-TCP structure. No additional phases were formed up to x = 4.5 in Ca9.5–xSrxCu(PO4)7. Biocompatibility tests were performed on cell lines of human bone marrow mesenchymal stromal cells (hMSC), human fibroblasts (MRC-5) and osteoblasts (U-2OS). It was demonstrated that cytotoxicity exhibited a concentration dependence, along with an increase in osteogenesis and cell proliferation. Ca9.5–xSrxCu(PO4)7 powders showed significant inhibitory activity against pathogenic strains Escherichia coli and Staphylococcus aureus. Piezoelectric properties of Ca9.5–xSrxCu(PO4)7 were investigated. Possible ways to achieve high piezoelectric response are discussed. The combination of bioactive properties of Ca9.5–xSrxCu(PO4)7 renders them multifunctional materials suitable for bone substitutes. Full article
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration)
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15 pages, 18476 KiB  
Article
Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®
by Imen Hammami, Manuel Pedro Fernandes Graça, Sílvia Rodrigues Gavinho, Suresh Kumar Jakka, João Paulo Borges, Jorge Carvalho Silva and Luís Cadillon Costa
Biomimetics 2024, 9(4), 213; https://doi.org/10.3390/biomimetics9040213 - 02 Apr 2024
Viewed by 879
Abstract
In recent decades, the requirements for implantable medical devices have increased, but the risks of implant rejection still exist. These issues are primarily associated with poor osseointegration, leading to biofilm formation on the implant surface. This study focuses on addressing these issues by [...] Read more.
In recent decades, the requirements for implantable medical devices have increased, but the risks of implant rejection still exist. These issues are primarily associated with poor osseointegration, leading to biofilm formation on the implant surface. This study focuses on addressing these issues by developing a biomaterial for implant coatings. 45S5 bioglass® has been widely used in tissue engineering due to its ability to form a hydroxyapatite layer, ensuring a strong bond between the hard tissue and the bioglass. In this context, 45S5 bioglasses®, modified by the incorporation of different amounts of copper oxide, from 0 to 8 mol%, were synthesized by the melt–quenching technique. The incorporation of Cu ions did not show a significant change in the glass structure. Since the bioglass exhibited the capacity for being polarized, thereby promoting the osseointegration effectiveness, the electrical properties of the prepared samples were studied using the impedance spectroscopy method, in the frequency range of 102–106 Hz and temperature range of 200–400 K. The effects of CuO on charge transport mobility were investigated. Additionally, the bioactivity of the modified bioglasses was evaluated through immersion tests in simulated body fluid. The results revealed the initiation of a Ca–P-rich layer formation on the surface within 24 h, indicating the potential of the bioglasses to enhance the bone regeneration process. Full article
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration)
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22 pages, 6382 KiB  
Article
Antimicrobial and Cell-Friendly Properties of Cobalt and Nickel-Doped Tricalcium Phosphate Ceramics
by Dina V. Deyneko, Vladimir N. Lebedev, Katia Barbaro, Vladimir V. Titkov, Bogdan I. Lazoryak, Inna V. Fadeeva, Alevtina N. Gosteva, Irina L. Udyanskaya, Sergey M. Aksenov and Julietta V. Rau
Biomimetics 2024, 9(1), 14; https://doi.org/10.3390/biomimetics9010014 - 31 Dec 2023
Cited by 1 | Viewed by 1227
Abstract
β-Tricalcium phosphate (β-TCP) is widely used as bone implant material. It has been observed that doping the β-TCP structure with certain cations can help in combating bacteria and pathogenic microorganisms. Previous literature investigations have focused on tricalcium phosphate structures with silver, copper, zinc, [...] Read more.
β-Tricalcium phosphate (β-TCP) is widely used as bone implant material. It has been observed that doping the β-TCP structure with certain cations can help in combating bacteria and pathogenic microorganisms. Previous literature investigations have focused on tricalcium phosphate structures with silver, copper, zinc, and iron cations. However, there are limited studies available on the biological properties of β-TCP containing nickel and cobalt ions. In this work, Ca10.5−xNix(PO4)7 and Ca10.5−xCox(PO4)7 solid solutions with the β-Ca3(PO4)2 structure were synthesized by a high-temperature solid-state reaction. Structural studies revealed the β-TCP structure becomes saturated at 9.5 mol/% for Co2+ or Ni2+ ions. Beyond this saturation point, Ni2+ and Co2+ ions form impurity phases after complete occupying of the octahedral M5 site. The incorporation of these ions into the β-TCP crystal structure delays the phase transition to the α-TCP phase and stabilizes the structure as the temperature increases. Biocompatibility tests conducted on adipose tissue-derived mesenchymal stem cells (aMSC) using the (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) (MTT) assay showed that all prepared samples did not exhibit cytotoxic effects. Furthermore, there was no inhibition of cell differentiation into the osteogenic lineage. Antibacterial properties were studied on the C. albicans fungus and on E. coli, E. faecalis, S. aureus, and P. aeruginosa bacteria strains. The Ni- and Co-doped β-TCP series exhibited varying degrees of bacterial growth inhibition depending on the doping ion concentration and the specific bacteria strain or fungus. The combination of antibacterial activity and cell-friendly properties makes these phosphates promising candidates for anti-infection bone substitute materials. Full article
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration)
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Review

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22 pages, 2937 KiB  
Review
The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives
by Md Amit Hasan Tanvir, Md Abdul Khaleque, Ga-Hyun Kim, Whang-Yong Yoo and Young-Yul Kim
Biomimetics 2024, 9(4), 230; https://doi.org/10.3390/biomimetics9040230 - 12 Apr 2024
Viewed by 868
Abstract
Osteoporosis is a skeletal disorder marked by compromised bone integrity, predisposing individuals, particularly older adults and postmenopausal women, to fractures. The advent of bioceramics for bone regeneration has opened up auspicious pathways for addressing osteoporosis. Research indicates that bioceramics can help bones grow [...] Read more.
Osteoporosis is a skeletal disorder marked by compromised bone integrity, predisposing individuals, particularly older adults and postmenopausal women, to fractures. The advent of bioceramics for bone regeneration has opened up auspicious pathways for addressing osteoporosis. Research indicates that bioceramics can help bones grow back by activating bone morphogenetic protein (BMP), mitogen-activated protein kinase (MAPK), and wingless/integrated (Wnt)/β-catenin pathways in the body when combined with stem cells, drugs, and other supports. Still, bioceramics have some problems, such as not being flexible enough and prone to breaking, as well as difficulties in growing stem cells and discovering suitable supports for different bone types. While there have been improvements in making bioceramics better for healing bones, it is important to keep looking for new ideas from different areas of medicine to make them even better. By conducting a thorough scrutiny of the pivotal role bioceramics play in facilitating bone regeneration, this review aspires to propel forward the rapidly burgeoning domain of scientific exploration. In the end, this appreciation will contribute to the development of novel bioceramics that enhance bone regrowth and offer patients with bone disorders alternative treatments. Full article
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration)
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Other

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17 pages, 1246 KiB  
Systematic Review
Influence of Immediate Dentin Sealing on Bond Strength of Resin-Based CAD/CAM Restoratives to Dentin: A Systematic Review of In Vitro Studies
by Iliana Antoniou, Petros Mourouzis, Dimitrios Dionysopoulos, Panagiotis Pandoleon and Kosmas Tolidis
Biomimetics 2024, 9(5), 267; https://doi.org/10.3390/biomimetics9050267 - 28 Apr 2024
Viewed by 394
Abstract
Immediate dentin sealing (IDS) is a method of improving the bond strength of indirect dental restorative materials to dentin and belongs to the biomimetic protocols of contemporary dentistry. The purpose of this systematic review was to evaluate the effect of IDS on the [...] Read more.
Immediate dentin sealing (IDS) is a method of improving the bond strength of indirect dental restorative materials to dentin and belongs to the biomimetic protocols of contemporary dentistry. The purpose of this systematic review was to evaluate the effect of IDS on the bond strength of resin-based CAD/CAM materials to dentin. PubMed and MEDLINE, Scopus, and the Web of Science were searched by two individual researchers, namely for studies that have been published in English between 1 January 2005 and 1 October 2022 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The inclusion criteria encompassed articles related to in vitro studies, measuring the bond strength through microtensile bond strength (μ-TBS), micro-shear bond strength (μ-SBS), tensile bond strength (TBS) or shear bond strength (SBS) tests after the use of the IDS technique. The included restorative materials comprised resin-based CAD/CAM materials bonded to dentin. A total of 1821 studies were identified, of which 7 met the inclusion criteria. A meta-analysis was not deemed appropriate due to the high level of diversity inthe publications and techniques. The use of IDS yielded higher bond strength outcomesin various experimental conditions and resin-based CAD/CAM materials. Overall, IDS in CAD/CAM restorations may contribute to better clinical outcomesand improved restoration longevity due to this property. Full article
(This article belongs to the Special Issue Advances in Bioceramics for Bone Regeneration)
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