Energy Metabolism in Cancers
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 5205
Special Issue Editor
Interests: anticancer therapy for hepatocellular carcinoma or other cancers; glycolysis; mitochondrial oxidation; energy metabolism; metastasis; epithelial to mesenchymal transition; chemo-resistance
Special Issue Information
Dear Colleagues,
Over the course of several decades, the survival of patients with cancers has increased due to advances in anticancer therapy such as immunotherapy (PD-1 blockade), tyrosine kinase inhibitors (sorafenib, lenvatinib, regorafenib, cabozantinib), or their combination therapy. However, the overall survival of cancer patients is still not satisfactory. Accordingly, we need a different point of view for anticancer therapy based on recent approaches in cancers. Energy metabolism is the process of generating energy in the form of adenosine triphosphate (ATP) from nutrients, including both glycolysis and mitochondrial respiration including fatty acid and amino acid metabolism. The metabolic pathways are highly regulated and interconnected to maintain ATP production in order to sustain all fundamental cellular processes in cancers. Cancer cells are known to exhibit dysregulated metabolic pathways, which contribute to metabolic flexibility that promotes aberrant cell proliferation and survival even under difficult conditions such as hypoxia. Given the critical importance of energy metabolism in cancers, alterations in key metabolic pathways lead to the development and progression of cancers. In contrast, energy depletion in cancers is one of the major triggers of the cancer cell death cascade and dysfunction of mitochondria. This Special Issue, entitled “Energy Metabolism in Cancers”, aims to present a collection of original research articles (basic, translational, or clinical) and reviews that address the molecular and cellular biology underlying various pathways in energy metabolism that contribute to the progression of cancers, or their initiation and metastasis. Studies on compounds that modulate energy metabolism as strategies to suppress cancer progression, metastasis, and resistance to anticancer therapy will also be considered.
Dr. Minjong Lee
Guest Editor
Manuscript Submission Information
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Keywords
- Warburg effect
- mitochondrial oxidation
- energy metabolism
- metastasis
- chemo-resistance
- glutamine
- fatty acid
