Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.7
4.7
Journals
Biomedicines
Special Issues
Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects
share announcement

Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 10954

Special Issue Editors

Prof. Dr. Aleksei V. Trofimov

E-Mail Website
Guest Editor
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
Interests: chemiluminescence (fundamentals, analytical & bioanalytical applications, biosensors); molecular spectroscopy; energy & electron transfer; free radicals; reactive oxygen species; bioantioxidants; oxidative stress; biomarkers
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Luciano Saso

grade E-Mail Website
Guest Editor
Faculty of Pharmacy and Medicine, Sapienza University of Rome, 00185 Rome, Italy
Interests: pharmacology; therapeutic modulators of oxidative stress
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In view of the vital importance of oxygen metabolism and oxidation chemistry in vivo, the biological role of diverse exogenous and endogenous compounds is often considered in the light of their ability to mediate and modify oxidative processes in living organisms, both in health and disease. In this context, it is noteworthy that many of these substances exhibit antioxidant activities, whose mechanisms are often related to pathways such as NRF2/KEAP1 but still require further studies from the pharmacological point of view. Clearly, overlapping the biochemical and physiological functions of various bioantioxidants adds complexity to such a mechanistic elucidation. Another intricacy stems from an inherent chemical sophistication of bioantioxidants’ properties. Some compounds known for their antioxidant activity may under certain conditions exhibit prooxidant properties.

The forthcoming Special Issue of Biomedicines, “Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects” is devoted to chemical and biological mechanisms of the functioning bioantioxidants in health and disease, as well as to the pertinent biomedical implications, drawing particular attention to unresolved contemporary issues which merit in-depth investigation. Contributions are invited concerning all kinds of endogenous and exogenous antioxidants, both natural and synthetics, but only research papers dealing with well-characterized substances and clear chemical composition will be considered for further processing. Critical reviews on this topic are also welcome.

Prof. Dr. Aleksei V. Trofimov
Prof. Dr. Luciano Saso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioantioxidants
  • oxidation
  • oxidative stress
  • reactive oxygen species
  • Nrf2
  • antioxidant enzymes
  • antioxidant therapy

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Editorial

Jump to: Research, Review

4 pages, 217 KiB  
Editorial
Chemical, Biological and Biomedical Aspects of Bioantioxidants
by Sarmistha Saha, Luciano Saso, Aleksei V. Trofimov and Olga I. Yablonskaya
Biomedicines 2023, 11(5), 1377; https://doi.org/10.3390/biomedicines11051377 - 06 May 2023
Viewed by 866
Abstract
Bioantioxidants are biologically important antioxidants, a heterogeneous variety of molecules, which are difficult to classify using commonly shared structural features [...] Full article
(This article belongs to the Special Issue Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects)

Research

Jump to: Editorial, Review

13 pages, 2584 KiB  
Article
The Identification of Prohibitin in the Rat Heart Mitochondria in Heart Failure
by Yulia Baburina, Roman Krestinin, Irina Odinokova, Irina Fadeeva, Linda Sotnikova and Olga Krestinina
Biomedicines 2021, 9(12), 1793; https://doi.org/10.3390/biomedicines9121793 - 29 Nov 2021
Cited by 6 | Viewed by 1691
Abstract
Mitochondria are considered the main organelles in the cell. They play an important role in both normal and abnormal heart function. There is a supramolecular organization between the complexes of the respiratory chain (supercomplexes (SCs)), which are involved in mitochondrial respiration. Prohibitins (PHBs) [...] Read more.
Mitochondria are considered the main organelles in the cell. They play an important role in both normal and abnormal heart function. There is a supramolecular organization between the complexes of the respiratory chain (supercomplexes (SCs)), which are involved in mitochondrial respiration. Prohibitins (PHBs) participate in the regulation of oxidative phosphorylation (OXPHOS) activity and interact with some subunits of the OXPHOS complexes. In this study, we identified a protein whose level was decreased in the mitochondria of the heart in rats with heart failure. This protein was PHB. Isoproterenol (ISO) has been used as a compound to induce heart failure in rats. We observed that astaxanthin (AX) increased the content of PHB in rat heart mitochondria isolated from ISO-injected rats. Since it is known that PHB forms complexes with some mitochondrial proteins and proteins that are part of the complexes of the respiratory chain, the change in the levels of these proteins was investigated under our experimental conditions. We hypothesized that PHB may be a target for the protective action of AX. Full article
(This article belongs to the Special Issue Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects)
►▼ Show Figures

Figure 1

15 pages, 1871 KiB  
Article
A Use of Tritium-Labeled Peat Fulvic Acids and Polyphenolic Derivatives for Designing Pharmacokinetic Experiments on Mice
by Gennady A. Badun, Maria G. Chernysheva, Yury V. Zhernov, Alina S. Poroshina, Valery V. Smirnov, Sergey E. Pigarev, Tatiana A. Mikhnevich, Dmitry S. Volkov, Irina V. Perminova and Elena I. Fedoros
Biomedicines 2021, 9(12), 1787; https://doi.org/10.3390/biomedicines9121787 - 29 Nov 2021
Cited by 5 | Viewed by 2025
Abstract
Natural products (e.g., polyphenols) have been used as biologically active compounds for centuries. Still, the mechanisms of biological activity of these multicomponent systems are poorly understood due to a lack of appropriate experimental techniques. The method of tritium thermal bombardment allows for non-selective [...] Read more.
Natural products (e.g., polyphenols) have been used as biologically active compounds for centuries. Still, the mechanisms of biological activity of these multicomponent systems are poorly understood due to a lack of appropriate experimental techniques. The method of tritium thermal bombardment allows for non-selective labeling and tracking of all components of complex natural systems. In this study, we applied it to label two well-characterized polyphenolic compounds, peat fulvic acid (FA-Vi18) and oxidized lignin derivative (BP-Cx-1), of predominantly hydrophilic and hydrophobic character, respectively. The identity of the labeled samples was confirmed using size exclusion chromatography. Using ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FT ICR MS), key differences in the molecular composition of BP-Cx-1 and FA-Vi18 were revealed. The labeled samples ([3H]-FA-Vi18 (10 mg/kg) and [3H]-BP-Cx-1 (100 mg/kg)) were administered to female BALB/c mice intravenously (i.v.) and orally. The label distribution was assessed in blood, liver, kidneys, brain, spleen, thymus, ovaries, and heart using liquid scintillation counting. Tritium label was found in all organs studied at different concentrations. For the fulvic acid sample, the largest accumulation was observed in the kidney (Cmax 28.5 mg/kg and 5.6 mg/kg, respectively) for both routes. The organs of preferential accumulation of the lignin derivative were the liver (Cmax accounted for 396.7 and 16.13 mg/kg for i.v. and p.o. routes, respectively) and kidney (Cmax accounted for 343.3 and 17.73 mg/kg for i.v. and p.o. routes, respectively). Our results demonstrate that using the tritium labeling technique enabled successful pharmacokinetic studies on polyphenolic drugs with very different molecular compositions. It proved to be efficient for tissue distribution studies. It was also shown that the dosage of the polyphenolic drug might be lower than 10 mg/kg due to the sensitivity of the 3H detection technique. Full article
(This article belongs to the Special Issue Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects)
►▼ Show Figures

Figure 1

Review

Jump to: Editorial, Research

12 pages, 1312 KiB  
Review
Cardioprotective Mechanisms against Reperfusion Injury in Acute Myocardial Infarction: Targeting Angiotensin II Receptors
by Gabriel Méndez-Valdés, Vicente Pérez-Carreño, Maria Chiara Bragato, Malthe Hundahl, Silvia Chichiarelli, Luciano Saso and Ramón Rodrigo
Biomedicines 2023, 11(1), 17; https://doi.org/10.3390/biomedicines11010017 - 22 Dec 2022
Cited by 3 | Viewed by 1814
Abstract
Ischemia/reperfusion injury is a process associated with cardiologic interventions, such as percutaneous coronary angioplasty after an acute myocardial infarction. Blood flow restoration causes a quick burst of reactive oxygen species (ROS), which generates multiple organelle damage, leading to the activation of cell death [...] Read more.
Ischemia/reperfusion injury is a process associated with cardiologic interventions, such as percutaneous coronary angioplasty after an acute myocardial infarction. Blood flow restoration causes a quick burst of reactive oxygen species (ROS), which generates multiple organelle damage, leading to the activation of cell death pathways. Therefore, the intervention contributes to a greater necrotic zone, thus increasing the risk of cardiovascular complications. A major cardiovascular ROS source in this setting is the activation of multiple NADPH oxidases, which could result via the occupancy of type 1 angiotensin II receptors (AT1R); hence, the renin angiotensin system (RAS) is associated with the generation of ROS during reperfusion. In addition, ROS can promote the expression of NF-κΒ, a proinflammatory transcription factor. Recent studies have described an intracellular RAS pathway that is associated with increased intramitochondrial ROS through the action of isoform NOX4 of NADPH oxidase, thereby contributing to mitochondrial dysfunction. On the other hand, the angiotensin II/ angiotensin type 2 receptor (Ang II/AT2R) axis exerts its effects by counter-modulating the action of AT1R, by activating endothelial nitric oxide synthase (eNOS) and stimulating cardioprotective pathways such as akt. The aim of this review is to discuss the possible use of AT1R blockers to hamper both the Ang II/AT1R axis and the associated ROS burst. Moreover; we suggest that AT1R antagonist drugs should act synergistically with other cardioprotective agents, such as ascorbic acid, N-acetylcysteine and deferoxamine, leading to an enhanced reduction in the reperfusion injury. This therapy is currently being tested in our laboratory and has shown promising outcomes in experimental studies. Full article
(This article belongs to the Special Issue Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects)
►▼ Show Figures

Figure 1

14 pages, 731 KiB  
Review
Potential Antioxidant Multitherapy against Complications Occurring in Sepsis
by Joaquin Abelli, Gabriel Méndez-Valdés, Francisca Gómez-Hevia, Maria Chiara Bragato, Silvia Chichiarelli, Luciano Saso and Ramón Rodrigo
Biomedicines 2022, 10(12), 3088; https://doi.org/10.3390/biomedicines10123088 - 01 Dec 2022
Cited by 5 | Viewed by 1413
Abstract
Septic shock currently represents one of the main causes of mortality in critical patient units with an increase in its incidence in recent years, and it is also associated with a high burden of morbidity in surviving patients. Within the pathogenesis of sepsis, [...] Read more.
Septic shock currently represents one of the main causes of mortality in critical patient units with an increase in its incidence in recent years, and it is also associated with a high burden of morbidity in surviving patients. Within the pathogenesis of sepsis, oxidative stress plays an important role. The excessive formation of reactive oxygen species (ROS) leads to mitochondrial damage and vasomotor dysfunction that characterizes those patients who fall into septic shock. Currently, despite numerous studies carried out in patients with septic shock of different causes, effective therapies have not yet been developed to reduce the morbidity and mortality associated with this pathology. Despite the contribution of ROS in the pathophysiology of sepsis and septic shock, most studies performed in humans, with antioxidant monotherapies, have not resulted in promising data. Nevertheless, some interventions with compounds such as ascorbate, N-acetylcysteine, and selenium would have a positive effect in reducing the morbidity and mortality associated with this pathology. However, more studies are required to demonstrate the efficacy of these therapies. Taking into account the multifactorial features of the pathophysiology of sepsis, we put forward the hypothesis that a supplementation based on the association of more than one antioxidant compound should result in a synergistic or additive effect, thus improving the beneficial effects of each of them alone, potentially serving as a pharmacological adjunct resource to standard therapy to reduce sepsis complications. Therefore, in this review, it is proposed that the use of combined antioxidant therapies could lead to a better clinical outcome of patients with sepsis or septic shock, given the relevance of oxidative stress in the pathogenesis of this multi-organ dysfunction. Full article
(This article belongs to the Special Issue Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects)
►▼ Show Figures

Figure 1

19 pages, 1553 KiB  
Review
Antioxidant Intervention against Male Infertility: Time to Design Novel Strategies
by Cristóbal Ávila, José Ignacio Vinay, Marzia Arese, Luciano Saso and Ramón Rodrigo
Biomedicines 2022, 10(12), 3058; https://doi.org/10.3390/biomedicines10123058 - 28 Nov 2022
Cited by 9 | Viewed by 1980
Abstract
Infertility is a highly prevalent condition, affecting 9–20% of couples worldwide. Among the identifiable causes, the male factor stands out in about half of infertile couples, representing a growing problem. Accordingly, there has been a decline in both global fertility rates and sperm [...] Read more.
Infertility is a highly prevalent condition, affecting 9–20% of couples worldwide. Among the identifiable causes, the male factor stands out in about half of infertile couples, representing a growing problem. Accordingly, there has been a decline in both global fertility rates and sperm counts in recent years. Remarkably, nearly 80% of cases of male infertility (MI) have no clinically identifiable aetiology. Among the mechanisms likely plausible to account for idiopathic cases, oxidative stress (OS) has currently been increasingly recognized as a key factor in MI, through phenomena such as mitochondrial dysfunction, lipid peroxidation, DNA damage and fragmentation and finally, sperm apoptosis. In addition, elevated reactive oxygen species (ROS) levels in semen are associated with worse reproductive outcomes. However, despite an increasing understanding on the role of OS in the pathophysiology of MI, therapeutic interventions based on antioxidants have not yet provided a consistent benefit for MI, and there is currently no clear consensus on the optimal antioxidant constituents or regimen. Therefore, there is currently no applicable antioxidant treatment against this problem. This review presents an approach aimed at designing an antioxidant strategy based on the particular biological properties of sperm and their relationships with OS. Full article
(This article belongs to the Special Issue Bioantioxidants in Health and Disease: Chemical, Biological and Biomedical Aspects)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop