Advances in Mechanism Research of Diabetes and Insulin Resistance

Dear Colleagues,

Diabetes is a chronic disease that affects millions of people worldwide, making it one of the biggest challenges of the 21st century. Hyperglycemia, leading to the generation of advanced glycations end products, and insulin resistance, leading to metabolic disorders and pancreatic beta cell death, are the major contributors to the development of type 2 diabetes mellitus. Insulin resistance is a complex condition where the body's cells become less sensitive to insulin, impairing its downstream metabolic actions, including the normalization of the serum glucose concentrations. Over the past few decades, mechanisms underlying diabetes and insulin resistance have been the subject of intense research, which has resulted in several key advancements. An increasing body of work has linked hyperglycemic memory, metabolic inflammation, lipid accumulation, advanced glycation end products (AGEs), mitochondrial dysfunction, oxidative stress, microbiota composition, and epigenetics changes with insulin resistance and diabetes mellitus. This Special Issue, entitled “Advances in Mechanism Research of Diabetes and Insulin Resistance”, will focus on all of these mechanistic aspects. This Special Issue aims to link advances in the mechanisms underlying diabetes and insulin resistance to the development of new treatments and management strategies. Targeting inflammation, improving mitochondrial function, reducing lipid accumulation, modulating the gut microbiota, and addressing epigenetic and hormonal factors are all potential avenues for future research and treatment development.

We are delighted to invite authors to submit original research and review articles related to multiple aspects of insulin resistance and diabetes mellitus. In this regard, special attention will be paid to novel mechanistic perspectives to develop more effective prevention and treatment strategies.

We look forward to receiving your contributions.

Prof. Dr. Abdu Adem
Dr. Sandro Massao Hirabara
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.