Special Issue "Advances in Mechanism Research of Diabetes and Insulin Resistance"
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 95
Interests: diabetes mellitus; insulin resistance; AGEs; inflammation; oxidative stress; epigenetic modifications; insulin signal perturbations
Diabetes is a chronic disease that affects millions of people worldwide, making it one of the biggest challenges of the 21st century. Hyperglycemia, leading to the generation of advanced glycations end products, and insulin resistance, leading to metabolic disorders and pancreatic beta cell death, are the major contributors to the development of type 2 diabetes mellitus. Insulin resistance is a complex condition where the body's cells become less sensitive to insulin, impairing its downstream metabolic actions, including the normalization of the serum glucose concentrations. Over the past few decades, mechanisms underlying diabetes and insulin resistance have been the subject of intense research, which has resulted in several key advancements. An increasing body of work has linked hyperglycemic memory, metabolic inflammation, lipid accumulation, advanced glycation end products (AGEs), mitochondrial dysfunction, oxidative stress, microbiota composition, and epigenetics changes with insulin resistance and diabetes mellitus. This Special Issue, entitled “Advances in Mechanism Research of Diabetes and Insulin Resistance”, will focus on all of these mechanistic aspects. This Special Issue aims to link advances in the mechanisms underlying diabetes and insulin resistance to the development of new treatments and management strategies. Targeting inflammation, improving mitochondrial function, reducing lipid accumulation, modulating the gut microbiota, and addressing epigenetic and hormonal factors are all potential avenues for future research and treatment development.
We are delighted to invite authors to submit original research and review articles related to multiple aspects of insulin resistance and diabetes mellitus. In this regard, special attention will be paid to novel mechanistic perspectives to develop more effective prevention and treatment strategies.
We look forward to receiving your contributions.
Prof. Dr. Abdu Adem
Dr. Sandro Massao Hirabara
Manuscript Submission Information
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