Advanced Research of Cartilage Repair and Regeneration

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 1508

Special Issue Editor


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Guest Editor
Department of Structural & Cellular Biology, Tulane University, New Orleans, LA 70112, USA
Interests: inflammation and cancer; prostate cancer; articular cartilage regeneration and repair

Special Issue Information

Dear Colleagues,

Arthritis is the most common cause of disability, the most common form of which is osteoarthritis (OA). Early OA is treated with joint-preserving interventions such as lifestyle modification, pharmaceuticals, and surgery. The most commonly used surgical modalities for the treatment of localized cartilage lesions in early OA are microfracture, mosaicplasty (osteochondral autograft), and autologous chondrocyte implantation. These therapies may restore function and relieve pain for a short period, but they are not able to arrest or delay disease progression. End-stage OA is treated with joint replacement; however, the functional outcomes can be poor and the lifespan of prostheses is limited. New strategies based on mesenchymal stem cells are being actively tested in humans and animals; however, few have been successfully translated into clinical practice. This Special Issue on Advanced Research of Cartilage Repair and Regeneration invites original and review articles focusing on stem cells, scaffold, and chondrogenic factors as well as their combinations for articular cartilage regeneration and repair. In vivo animal studies with long-term (24 months and beyond) follow-up are particularly welcome.

Prof. Dr. Zongbing You
Guest Editor

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Keywords

  • articular cartilage
  • stem cells
  • scaffold
  • chondrogenic factor
  • cartilage repair
  • cartilage regeneration
  • regenerative medicine
  • tissue engineering
  • chondrocytes
  • articular joint

Published Papers (1 paper)

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Research

13 pages, 1071 KiB  
Article
Change in Cartilage Status of Medial Compartment after Open-Wedge High Tibial Osteotomy without Cartilage Regeneration Procedure: Second Look Arthroscopic Assessment
by Sung-Sahn Lee, Juyong Oh and Dae-Hee Lee
Biomedicines 2023, 11(6), 1639; https://doi.org/10.3390/biomedicines11061639 - 5 Jun 2023
Cited by 2 | Viewed by 1183
Abstract
This study investigated the rate of cartilage regeneration after an open-wedge high tibial osteotomy (HTO) without cartilage regeneration by second-look arthroscopy. This study included patients who underwent an open-wedge HTO between July 2014 and March 2019. A total of 65 patients were enrolled. [...] Read more.
This study investigated the rate of cartilage regeneration after an open-wedge high tibial osteotomy (HTO) without cartilage regeneration by second-look arthroscopy. This study included patients who underwent an open-wedge HTO between July 2014 and March 2019. A total of 65 patients were enrolled. Pre- and postoperative (second-look arthroscopy) hip–knee–ankle (HKA) angle and tibial slope were measured. All patients underwent arthroscopic examination prior to osteotomy. Medial femoral condyle (MFC) and medial tibial plateau (MTP) articular cartilage were evaluated according to the International Cartilage Repair Society (ICRS) grading system. After 26.5 months, second-look arthroscopy was performed with plate removal to identify the cartilage status of the MFC and MTP. The preoperative HKA angle (6.4° ± 2.7°) was well corrected postoperatively (−2.7° ± 2.7°, p < 0.001). In terms of MFC on second-look arthroscopy, 29 patients (44.6%) showed an improved ICRS grade, 31 patients (47.7%) were maintained, and 5 patients (7.7%) showed a worse ICRS grade since the prior operation. In the MTP group, 19 patients (29.2%) improved, 44 patients (67.7%) were maintained, and 2 patients (3.1%) worsened. Approximately 44.6% and 29.2% of patients showed improved cartilage statuses on the MFC and MTP after open-wedge HTO without any cartilage regeneration procedures. Cartilage regenerations in both the MFC and MTP did not influence clinical outcomes. Full article
(This article belongs to the Special Issue Advanced Research of Cartilage Repair and Regeneration)
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