Melanoma: Epigenetic Modification, Molecular Changes, and Precision Targeting
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 1216
Special Issue Editors
Interests: epigenetics; DNA methylation; histone modifications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Melanoma, a formidable form of skin cancer, primarily emerges from the malignant transformation of melanin pigment-producing melanocytes within the basal layer of the epidermis. The etiology of melanoma transformation, known as melanomagenesis, is an intricate process, stemming from sequential modifications in transcriptional pathways orchestrated by diverse mechanisms.
These mechanisms encompass direct mutations affecting gene regulators such as BRAF, NF1, and RAS, coupled with alterations in their expression levels that trigger perturbations in transcription. This cascade subsequently modifies downstream signaling pathways. Given the nuclear sequestration of genes associated with heightened melanoma susceptibility through chromatinization, and considering chromatin's role in regulating the transcriptional competence of cellular genes, it is plausible that chromatin-dependent pathways contribute to the underlying mechanisms of melanomagenesis. Although this intriguing avenue remains incompletely explored, indirect evidence indicates associations between chromatin reorganization and transcriptional dysregulation in melanoma cells.
The focal intent of this Special Issue lies in curating a compendium of primary research papers and review articles, showcasing burgeoning paradigms in the realm of epigenetics' role in governing diverse pathologies. By doing so, it seeks to provide novel insights into the molecular mechanisms and cellular pathways that orchestrate these processes.
Dr. Yonghwan Shin
Dr. Sungmin Kim
Guest Editors
Manuscript Submission Information
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Keywords
- melanoma
- melanomagenesis
- epigenetics
- histone modification
- DNA methylation
