Multimodal Interdisciplinary Approach of Tumor Vasculogenesis and Angiogenesis in Oncology
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1137
Special Issue Editor
Interests: histology; histopathology; tumor and non-tumor angiogenesis; vasculogenesis; digital image analysis; molecular biology; experimental models; chick embryo chorioallantoic membrane; microfluidic systems for tumor, vasculogenesis and angiogenesis research; immunohistochemistry; RNA scope; immunofluorescence; medical education; microscopy; in vitro studies; breast cancer; renal cancer; thymus; thymomas; pituitary adenomas; ovarian cancer; targeted tumor therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The observation of tumor vasculature dates back to ancient times. However, the idea of targeting tumor vessels was developed in the late 1960s and early 1970s by Professor Judah Folkman. He introduced the concept of tumor angiogenesis and conducted extensive preclinical and clinical studies to develop therapies that focused on angiogenic growth factors. Additionally, he explored the inhibition of tumor vasculature development as a potential mechanism to halt the development of various types of cancer. Despite the approval of clinical anti-angiogenic or anti-vascular therapies, the mechanisms of initiation and resistance development in tumor angiogenesis are not yet fully understood. During the 1980s, Höpfel-Kreiner identified a developmental stage of infantile hemangiomas that closely resembles embryonic vasculogenesis. However, that there are only 1000 articles in the literature dedicated to the topic of tumor vasculogenesis, which is still a highly controversial and incompletely understood subject. Most of these papers focused on tumor vasculogenesis in preclinical studies and, to a lesser extent, in clinical research. Based on these facts, we launch the present Special Issue open for reviews, original papers, new and innovative experimental models and techniques and clinical research in the field of tumor angiogenesis and vasculogenesis. This Special Issue is addressed to researchers from the field of basic science but also is open for clinicians, oncologists, pharmacists, radiologists, surgeons and radiotherapy specialists who applied experimental and clinical methods targeting tumor angiogenesis and vasculogenesis.The main topics are as follows:
- Tumor endothelial cells heterogeneity and its impact on tumor angiogenesis and vasculogenesis.
- Molecular characterization of cells initiating tumor vasculogenesis.
- New innovative experimental models for the study of tumor angiogenesis and vasculogenesis.
- Chemotherapy and radiotherapy as friends or foes of tumor angiogenesis and vasculogenesis.
- Malignant cells involvement in tumor vasculogenesis.
- Tumor stroma immune microenvironment and its modulation related to tumor angiogenesis and vasculogenesis.
- New radiologic research techniques for in vivo study of tumor angiogenesis and vasculogenesis and for targeting tumor vessels.
- Nanotechnology, tumor angiogenesis and vasculogenesis.
- Artificial intelligence, tumor vasculogenesis and angiogenesis.
- Pathologist role in the assessment of tumor angiogenesis and vasculogenesis by conventional immunohistochemistry and digital image analysis and its impact on initial preliminary diagnosis.
Dr. Anca-Maria Cimpean
Guest Editor
Manuscript Submission Information
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Keywords
- tumor vasculogenesis
- tumor angiogenesis
- vascular normalization
- anti-angiogenic/anti-vascular targeted therapies
