Neurodegenerative Diseases: From Mechanisms to Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 926
Special Issue Editor
Interests: neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are characterized by the progressive degeneration of the nervous system. These diseases result in the progressive and irreversible loss of neurons, leading to cognitive decline or motor dysfunction. The best-known neurodegenerative diseases are Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Neurodegeneration can result from different mechanisms: (a) Protein misfolding and aggregation. Beta-amyloid peptide and tau protein have been implicated in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and huntingtin in Huntington’s disease. (b) Oxidative stress damages cellular structures, including neurons, and may contribute to their degeneration. (c) Chronic inflammation within the nervous system can exacerbate neuronal damage and contribute to the progression of neurodegenerative diseases. (d) Mutations in specific genes can increase an individual’s susceptibility to developing these diseases. For example, mutations in the APP, PSEN1, and PSEN2 genes are associated with familial forms of early onset Alzheimer's disease.
The aim of this Special Issue of Biomedecines is to present mechanisms involved in neurodegenerative diseases, or to outline therapeutic approaches with their progress and pitfalls.
Dr. Marie-Lise Maddelein
Guest Editor
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Keywords
- neurodegenerative diseases
- neurons
- mechanism
