Advances in Nanomaterial-Based Drug Delivery Systems

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1304

Special Issue Editor


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Guest Editor
Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
Interests: nanomedicine; drug delivery; pharmaceutical nanotechnology; cancer therapy; gene therapy

Special Issue Information

Dear Colleagues,

I would like to invite you to contribute new discoveries that may help advance the applications of nanotechnology in drug delivery.

Nanotechnology has been utilized in clinics. For example, two nanomedicines, liposome-based doxorubicin (Doxil) and albumin-conjugated paclitaxel (Abraxane), have been approved by the FDA for cancer chemotherapy. The recent success of mRNA COVID-19 vaccines has meant the development of nanotechnology-driven drug delivery systems has thrived.

Despite remarkable progress in the past few decades, challenges are still associated with nanomedicine. Biological barriers limit nanoparticles’ delivery of therapeutic drugs to the desired tissues or cells. The low efficiency of clinical translation indicates that there are safety and regulation issues. This Special Issue aims to publish up-to-date progress in engineering novel nanomaterials and formulations for delivering small-molecule and biologic drugs, strategies of enhancing the therapeutic outcome in treating diseases, such as cancer and autoimmune and infectious diseases, and  mechanisms of improving the delivery efficiency of nanoparticles. I hope the contributions to this Special Issue will cast some light on improving the therapeutic effect and reducing the side effects of nanoparticle-based drug delivery systems in cancer therapy, gene therapy, and immunotherapy.

Dr. Donghui Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • drug delivery
  • nanomedicine
  • delivery efficiency
  • cancer therapy
  • gene therapy
  • immunotherapy

Published Papers (1 paper)

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Review

18 pages, 945 KiB  
Review
Advances in Nrf2 Signaling Pathway by Targeted Nanostructured-Based Drug Delivery Systems
by Sarmistha Saha, Nadezhda Sachivkina, Arfenya Karamyan, Ekaterina Novikova and Tamara Chubenko
Biomedicines 2024, 12(2), 403; https://doi.org/10.3390/biomedicines12020403 - 09 Feb 2024
Viewed by 1154
Abstract
Nanotechnology has gained significant interest in various applications, including sensors and therapeutic agents for targeted disease sites. Several pathological consequences, including cancer, Alzheimer’s disease, autoimmune diseases, and many others, are mostly driven by inflammation and Nrf2, and its negative regulator, the E3 ligase [...] Read more.
Nanotechnology has gained significant interest in various applications, including sensors and therapeutic agents for targeted disease sites. Several pathological consequences, including cancer, Alzheimer’s disease, autoimmune diseases, and many others, are mostly driven by inflammation and Nrf2, and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), plays a crucial role in maintaining redox status, the expression of antioxidant genes, and the inflammatory response. Interestingly, tuning the Nrf2/antioxidant response element (ARE) system can affect immune–metabolic mechanisms. Although many phytochemicals and synthetic drugs exhibited potential therapeutic activities, poor aqueous solubility, low bioavailability, poor tissue penetration, and, consequently, poor specific drug targeting, limit their practical use in clinical applications. Also, the therapeutic use of Nrf2 modulators is hampered in clinical applications by the absence of efficient formulation techniques. Therefore, we should explore the engineering of nanotechnology to modulate the inflammatory response via the Nrf2 signaling pathway. This review will initially examine the role of the Nrf2 signaling pathway in inflammation and oxidative stress-related pathologies. Subsequently, we will also review how custom-designed nanoscale materials encapsulating the Nrf2 activators can interact with biological systems and how this interaction can impact the Nrf2 signaling pathway and its potential outcomes, emphasizing inflammation. Full article
(This article belongs to the Special Issue Advances in Nanomaterial-Based Drug Delivery Systems)
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