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Biomedicines
Special Issues
Musculoskeletal Regenerative Medicine
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Musculoskeletal Regenerative Medicine

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 3928

Special Issue Editors

Dr. Ashim Gupta

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Guest Editor
South Texas Orthopaedic Research Institute, Laredo, TX, USA
Interests: orthopedic surgery; regenerative medicine; shoulder arthroplasty; shoulder arthroscopy; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Nicola Maffulli

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Guest Editor
1. Barts and The London School of Medicine and Dentistry, Mile End Hospital, Queen Mary University of London, 275 Bancroft Road, London E1 4DG, UK
2. School of Pharmacy and Bioengineering, Keele University Faculty of Medicine, Thornburrow Drive, Stoke on Trent ST4 7QB, UK
3. Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Fisciano, Italy
Interests: orthopaedic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Musculoskeletal injuries involve bones, ligaments, muscles, and tendons, producing pain, loss of function, instability, and, in the long term, osteoarthritis. Traditionally, the management of these injuries involves activity modification, physical therapy, pharmacological agents, including non-steroidal anti-inflammatory drugs, corticosteroid viscosupplementation, and narcotics, as well as a variety of surgical procedures. All of these modalities have limitations and potential side effects.

Over the last decade, there has been an increasing interest in the use of biologics for regenerative medicine applications. In regenerative medicine, functional tissue is engineered to repair, regenerate, or replace cells, tissues, or organs to restore and/or establish normal function lost from age, disease, damage, or congenital defects. Both autologous and allogenic biologics are currently used in clinical practice. Autologous biologics include platelet-rich plasma, bone marrow aspirate/concentrate, and adipose tissue aspirate. Allogenic biologics include formulations derived from perinatal tissues, including amniotic fluid, amniotic membrane, umbilical cord, and umbilical cord blood. The healing potential of these products is attributed to the presence of stem cells, growth factors, cytokines, hyaluronic acid, and extracellular vesicles, including exosomes.

Dr. Ashim Gupta
Prof. Dr. Nicola Maffulli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • stem cells
  • exosomes
  • musculoskeletal injuries
  • osteoarthritis
  • bone
  • cartilage
  • ligament
  • tendon
  • tissue engineering

Published Papers (4 papers)

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Editorial

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4 pages, 213 KiB  
Editorial
StemOneTM/Stempeucel®: CDSCO Approved, Adult Human Bone Marrow-Derived, Cultured, Pooled, Allogenic Mesenchymal Stem Cells for Knee Osteoarthritis
by Ashim Gupta
Biomedicines 2023, 11(11), 2894; https://doi.org/10.3390/biomedicines11112894 - 26 Oct 2023
Cited by 1 | Viewed by 950
Abstract
The knee, the most likely joint to present osteoarthritis (OA), is accountable for approximately 80% of the global burden of the OA [...] Full article
(This article belongs to the Special Issue Musculoskeletal Regenerative Medicine)
3 pages, 178 KiB  
Editorial
Combination of Platelet-Rich Plasma and Hyaluronic Acid vs. Platelet-Rich Plasma Alone for Treatment of Knee Osteoarthritis
by Ashim Gupta, Surya Prakash Sharma and Anish G. Potty
Biomedicines 2023, 11(10), 2759; https://doi.org/10.3390/biomedicines11102759 - 12 Oct 2023
Cited by 2 | Viewed by 966
Abstract
Knee osteoarthritis (OA) is the most documented form of OA and is accountable for about 80% of total OA cases worldwide [...] Full article
(This article belongs to the Special Issue Musculoskeletal Regenerative Medicine)

Research

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11 pages, 590 KiB  
Article
Platelet-Rich Plasma Injections in Chronic Lateral Ankle Instability: A Case Series
by Ivan Medina-Porqueres, Pablo Martin-Garcia, Sofia Sanz-De-Diego, Marcelo Reyes-Eldblom, Francisco Moya-Torrecilla, Rafael Mondragon-Cortes, Daniel Rosado-Velazquez and Abel Gomez-Caceres
Biomedicines 2024, 12(5), 963; https://doi.org/10.3390/biomedicines12050963 (registering DOI) - 26 Apr 2024
Viewed by 202
Abstract
The platelet-rich plasma (PRP) approach may be an effective treatment for joint and cartilage pathologies. However, the rationale for its effectiveness on joint instability is limited. This study aimed to assess the safety and effectiveness of PRP injections in patients with chronic lateral [...] Read more.
The platelet-rich plasma (PRP) approach may be an effective treatment for joint and cartilage pathologies. However, the rationale for its effectiveness on joint instability is limited. This study aimed to assess the safety and effectiveness of PRP injections in patients with chronic lateral ankle instability (CLAI). This retrospective study was performed at a single-center outpatient clinic between January 2015 and February 2023 and included pre-intervention assessment and short-term follow-up. Patients were excluded if they had received previous surgical treatment or had constitutional hyperlaxity, systemic diseases, or grade II or III osteoarthritis. The clinical and functional evaluation consisted of the Karlsson score, the Cumberland Ankle Instability Tool (CAIT), Good’s grading system, the patient’s subjective satisfaction level, and the time required to return to exercise. The entire PRP therapy regime consisted of three PRP administrations at 7-day intervals and follow-up appointments. PRP was administered both intraarticularly and into talofibular ligaments. A total of 47 consecutive patients with CLAI were included, 11 were female (23.4%), with a mean age at intervention of 31.19 ± 9.74 years. A statistically significant improvement was found in the CAIT and Karlsson scores at 3 months (27.74 ± 1.68 and 96.45 ± 4.28, respectively) relative to the pre-intervention status (10.26 ± 4.33 and 42.26 ± 14.9, respectively, p < 0.000). The mean follow-up of patients with CLAI was 17.94 ± 3.25 weeks. This study represents successful short-term functional and clinical outcomes in patients with CLAI after PRP treatment, with no adverse effects. It demonstrates the feasibility of a randomized controlled trial to further assess this therapy. Full article
(This article belongs to the Special Issue Musculoskeletal Regenerative Medicine)
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12 pages, 855 KiB  
Article
Positive Correlation between Relative Concentration of Spermine to Spermidine in Whole Blood and Skeletal Muscle Mass Index: A Possible Indicator of Sarcopenia and Prognosis of Hemodialysis Patients
by Hidenori Sanayama, Kiyonori Ito, Susumu Ookawara, Takeshi Uemura, Sojiro Imai, Satoshi Kiryu, Miho Iguchi, Yoshio Sakiyama, Hitoshi Sugawara, Yoshiyuki Morishita, Kaoru Tabei, Kazuei Igarashi and Kuniyasu Soda
Biomedicines 2023, 11(3), 746; https://doi.org/10.3390/biomedicines11030746 - 01 Mar 2023
Cited by 3 | Viewed by 1523
Abstract
Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal failure. Hemodialysis (HD) may compensate for polyamine excretion; however, little is [...] Read more.
Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal failure. Hemodialysis (HD) may compensate for polyamine excretion; however, little is known about polyamine excretion. We measured whole-blood polyamine levels in patients on HD and examined the relationship between polyamine concentrations and indicators associated with health status. Study participants were 59 hemodialysis patients (median age: 70.0 years) at Minami-Uonuma City Hospital and 26 healthy volunteers (median age: 44.5 years). Whole-blood spermidine levels were higher and spermine/spermidine ratio (SPM/SPD) was lower in hemodialysis patients. Hemodialysis showed SPD efflux into the dialysate; however, blood polyamine levels were not altered by hemodialysis and appeared to be minimally excreted. The skeletal muscle mass index (SMI), which was positively correlated with hand grip strength and serum albumin level, was positively correlated with SPM/SPD. Given that sarcopenia and low serum albumin levels are reported risk factors for poor prognosis in HD patients, whole blood SPM/SPD in hemodialysis patients may be a new indicator of the prognosis and health status of HD patients. Full article
(This article belongs to the Special Issue Musculoskeletal Regenerative Medicine)
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