Sigma-1 Receptor in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2220

Special Issue Editor


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Guest Editor
1. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan
2. Neuroscience and Brain Disease Center, China Medical University, Taichung 404333, Taiwan
Interests: sigma-1 receptor; neurological diseases; glioblastoma; nucleocytoplasmic transport function

Special Issue Information

Dear Colleagues,

Our Special Issue focuses on the biological function of the Sigma-1 receptor in health and diseases. Specifically, it explores research trends in Sigma-1R-related areas, to assess their potential for the treatment of diseases. The scope of the Special Issue includes neurobiology, cancer biology, inflammation-related diseases, biomedicines, signal transduction, nuclear and cytosol transport, gene regulation, cell death, and cell biology. Currently, more studies are focusing on the new biological functions of Sigma-1R in neurological diseases. We encourage not only neuroscientists but also researchers from other fields to submit manuscripts for this Special Issue. Hopefully, the Sigma-1R can be used as a translational therapeutic target for the treatment of various diseases.

Dr. Shao-Ming Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sigma-1 receptor
  • signaling transduction
  • biochemsity
  • molecular neurobiology
  • neurological diseases

Published Papers (1 paper)

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Research

22 pages, 4629 KiB  
Article
Genetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice
by Sergio López-Estévez, Mònica Aguilera, Georgia Gris, Beatriz de la Puente, Alicia Carceller and Vicente Martínez
Biomedicines 2023, 11(10), 2758; https://doi.org/10.3390/biomedicines11102758 - 12 Oct 2023
Viewed by 1417
Abstract
Sigma-1 receptors (σ1Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ1Rs on acute colitis-associated hypersensitivity using both genetic (constitutive knockout) and pharmacological blockade of the receptor. Colitis was induced in CD1 wild-type [...] Read more.
Sigma-1 receptors (σ1Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ1Rs on acute colitis-associated hypersensitivity using both genetic (constitutive knockout) and pharmacological blockade of the receptor. Colitis was induced in CD1 wild-type (WT) and σ1R KO mice (exposure to dextran sodium sulfate, 3%). A von Frey test was used to assess referred mechanosensitivity (abdominal and plantar withdrawal responses). The effects of the selective σ1R antagonists BD1063 and E-52862 were also assessed in WT animals. The expression of immune and sensory-related markers (RT-qPCR, Western blot) was assessed in the colon and lumbosacral spinal cord. The genetic ablation or pharmacological blockade of σ1Rs attenuated acute colonic inflammation in a similar manner. Mechanosensitivity was similar in WT and σ1R KO mice before colitis. In WT mice, but not in σ1R KO, colitis was associated with the development of referred mechanical hypersensitivity, manifested as a reduction in the withdrawal thresholds to mechanical probing (paw and abdominal wall). In WT mice, BD1063 and E-52862 blocked colitis-associated hypersensitivity. A genotype- and treatment-related differential regulation of sensory-related markers was detected locally (colon) and within the spinal cord. σ1Rs are involved in the development of acute intestinal inflammation and its associated referred mechanical hypersensitivity. The selective modulation of sensory-related pathways within the colon and spinal cord might be part of the underlying mechanisms. These observations support the pharmacological use of σ1R antagonists for the treatment of intestinal inflammation-induced hypersensitivity. Full article
(This article belongs to the Special Issue Sigma-1 Receptor in Health and Disease)
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