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Biomedicines
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Advanced Research in Nanomaterials for Biomedical Applications
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Advanced Research in Nanomaterials for Biomedical Applications

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 8118

Special Issue Editors

Dr. Hana Barošová

E-Mail Website
Guest Editor
Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic
Interests: nanomaterial; multicellular human alveolar model; hazard assessment
Dr. Patricia Taladriz-Blanco

E-Mail Website
Guest Editor
International Iberian Nanotechnology Laboratory (INL), Water Quality Group, Av. Mestre José Veiga s/n, 4715-530 Braga, Portugal
Interests: nanoparticles; microfluidics; nanobio interactions; thermoplasmonics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of nanomaterials has boosted biomedical applications, including drug delivery, tissue engineering, bioimaging, biosensing, antimicrobial, microbots, or diagnostics, as nanomaterials present tuneable and frequently improved physicochemical properties compared to conventional materials. As such, nanomaterials can be utilised for unusual applications, and a single nanomaterial can have multiplexed functionalities.

In this Special Issue, we invite you to contribute a full article, methods paper, review, within the scope of advanced biological or medical applications, synthesis, design, characterisation, and safety-related studies of nanomaterials.

Dr. Hana Barošová
Dr. Patricia Taladriz-Blanco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanoparticle
  • drug delivery
  • tissue engineering

Published Papers (3 papers)

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Research

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16 pages, 2809 KiB  
Article
ASL mRNA-LNP Therapeutic for the Treatment of Argininosuccinic Aciduria Enables Survival Benefit in a Mouse Model
by Owen Daly, Azita Josefine Mahiny, Sara Majeski, Kevin McClintock, Julia Reichert, Gábor Boros, Gábor Tamás Szabó, Jonas Reinholz, Petra Schreiner, Steve Reid, Kieu Lam, Marlen Lepper, Melanie Adler, Tracy Meffen, James Heyes, Katalin Karikó, Pete Lutwyche and Irena Vlatkovic
Biomedicines 2023, 11(6), 1735; https://doi.org/10.3390/biomedicines11061735 - 16 Jun 2023
Cited by 3 | Viewed by 3478
Abstract
Argininosuccinic aciduria (ASA) is a metabolic disorder caused by a deficiency in argininosuccinate lyase (ASL), which cleaves argininosuccinic acid to arginine and fumarate in the urea cycle. ASL deficiency (ASLD) leads to hepatocyte dysfunction, hyperammonemia, encephalopathy, and respiratory alkalosis. Here we describe a [...] Read more.
Argininosuccinic aciduria (ASA) is a metabolic disorder caused by a deficiency in argininosuccinate lyase (ASL), which cleaves argininosuccinic acid to arginine and fumarate in the urea cycle. ASL deficiency (ASLD) leads to hepatocyte dysfunction, hyperammonemia, encephalopathy, and respiratory alkalosis. Here we describe a novel therapeutic approach for treating ASA, based on nucleoside-modified messenger RNA (modRNA) formulated in lipid nanoparticles (LNP). To optimize ASL-encoding mRNA, we modified its cap, 5′ and 3′ untranslated regions, coding sequence, and the poly(A) tail. We tested multiple optimizations of the formulated mRNA in human cells and wild-type C57BL/6 mice. The ASL protein showed robust expression in vitro and in vivo and a favorable safety profile, with low cytokine and chemokine secretion even upon administration of increasing doses of ASL mRNA-LNP. In the ASLNeo/Neo mouse model of ASLD, intravenous administration of the lead therapeutic candidate LNP-ASL CDS2 drastically improved the survival of the mice. When administered twice a week lower doses partially protected and 3 mg/kg LNP-ASL CDS2 fully protected the mice. These results demonstrate the considerable potential of LNP-formulated, modified ASL-encoding mRNA as an effective alternative to AAV-based approaches for the treatment of ASA. Full article
(This article belongs to the Special Issue Advanced Research in Nanomaterials for Biomedical Applications)
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16 pages, 4048 KiB  
Article
A Near-Infrared Mechanically Switchable Elastomeric Film as a Dynamic Cell Culture Substrate
by Giovanni Spiaggia, Patricia Taladriz-Blanco, Stefan Hengsberger, Dedy Septiadi, Christoph Geers, Aaron Lee, Barbara Rothen-Rutishauser and Alke Petri-Fink
Biomedicines 2023, 11(1), 30; https://doi.org/10.3390/biomedicines11010030 - 22 Dec 2022
Cited by 1 | Viewed by 1232
Abstract
Commercial static cell culture substrates can usually not change their physical properties over time, resulting in a limited representation of the variation in biomechanical cues in vivo. To overcome this limitation, approaches incorporating gold nanoparticles to act as transducers to external stimuli have [...] Read more.
Commercial static cell culture substrates can usually not change their physical properties over time, resulting in a limited representation of the variation in biomechanical cues in vivo. To overcome this limitation, approaches incorporating gold nanoparticles to act as transducers to external stimuli have been employed. In this work, gold nanorods were embedded in an elastomeric matrix and used as photothermal transducers to fabricate biocompatible light-responsive substrates. The nanocomposite films analysed by lock-in thermography and nanoindentation show a homogeneous heat distribution and a greater stiffness when irradiated with NIR light. After irradiation, the initial stiffness values were recovered. In vitro experiments performed during NIR irradiation with NIH-3T3 fibroblasts demonstrated that these films were biocompatible and cells remained viable. Cells cultured on the light stiffened nanocomposite exhibited a greater proliferation rate and stronger focal adhesion clustering, indicating increased cell-surface binding strength. Full article
(This article belongs to the Special Issue Advanced Research in Nanomaterials for Biomedical Applications)
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Review

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50 pages, 5554 KiB  
Review
Nanoparticle Synthesis and Their Integration into Polymer-Based Fibers for Biomedical Applications
by Joana M. Domingues, Catarina S. Miranda, Natália C. Homem, Helena P. Felgueiras and Joana C. Antunes
Biomedicines 2023, 11(7), 1862; https://doi.org/10.3390/biomedicines11071862 - 29 Jun 2023
Cited by 5 | Viewed by 2772
Abstract
The potential of nanoparticles as effective drug delivery systems combined with the versatility of fibers has led to the development of new and improved strategies to help in the diagnosis and treatment of diseases. Nanoparticles have extraordinary characteristics that are helpful in several [...] Read more.
The potential of nanoparticles as effective drug delivery systems combined with the versatility of fibers has led to the development of new and improved strategies to help in the diagnosis and treatment of diseases. Nanoparticles have extraordinary characteristics that are helpful in several applications, including wound dressings, microbial balance approaches, tissue regeneration, and cancer treatment. Owing to their large surface area, tailor-ability, and persistent diameter, fibers are also used for wound dressings, tissue engineering, controlled drug delivery, and protective clothing. The combination of nanoparticles with fibers has the power to generate delivery systems that have enhanced performance over the individual architectures. This review aims at illustrating the main possibilities and trends of fibers functionalized with nanoparticles, focusing on inorganic and organic nanoparticles and polymer-based fibers. Emphasis on the recent progress in the fabrication procedures of several types of nanoparticles and in the description of the most used polymers to produce fibers has been undertaken, along with the bioactivity of such alliances in several biomedical applications. To finish, future perspectives of nanoparticles incorporated within polymer-based fibers for clinical use are presented and discussed, thus showcasing relevant paths to follow for enhanced success in the field. Full article
(This article belongs to the Special Issue Advanced Research in Nanomaterials for Biomedical Applications)
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