Endocrinology of Reproduction and Sexuality: Insights into the Molecular Aspects

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1548

Special Issue Editor


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Guest Editor
Department of Clinical and Experimental Medicine, University of Catania, 95125 Catania, Italy
Interests: endocrinology of reproduction and sexuality

Special Issue Information

Dear Colleagues,

Reproductive endocrinology is still facing numerous challenges. Reproductive disorders can include a broad range of symptoms, including hirsutism, alterations of the menstrual cycle, infertility, and sexual dysfunctions.

Despite their high prevalence in both sexes, sexual health is often neglected in clinical practices. The identification of sexual dysfunctions can also highlight underlying conditions and predict major comorbid disorders, including cardiovascular diseases. The pathogenesis of sexual dysfunctions is complex and multifactorial, including both organic (vascular, neurogenic, endocrine, etc.) and psychological causes, which often overlap and worsen each other. Lifestyle risk factors, including smoking, physical inactivity, obesity, and excessive alcohol, as well as drug consumption, may deeply impair reproduction and sexual functions in both women and men.

This Special Issue aspires to give an overview of popular reproductive endocrinology issues and to deeply examine the molecular aspects underlying sexual dysfunctions and reproductive diseases in both women and men. Understanding the molecular mechanisms that are involved in the etiology and progression of these disorders could increase our ability to identify new targets for their treatment and their related consequences for people’s general health and quality of life.

Dr. Federica Barbagallo
Guest Editor

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Keywords

  • reproduction
  • reproductive endocrinology
  • infertility
  • sexual health
  • sexual functioning
  • female sexual dysfunction
  • hypoactive sexual desire disorder
  • dyspareunia
  • anorgasmia
  • erectile dysfunction
  • premature ejaculation
  • amenorrhea
  • polycystic ovary syndrome (PCOS)
  • functional hypothalamic amenorrhea (FHA)
  • male hypogonadism
  • female hypogonadism
  • contraception

Published Papers (1 paper)

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Review

21 pages, 1728 KiB  
Review
The Role of Irisin throughout Women’s Life Span
by Federica Barbagallo, Rossella Cannarella, Vincenzo Garofalo, Marta Marino, Sandro La Vignera, Rosita A. Condorelli, Lara Tiranini, Rossella E. Nappi and Aldo E. Calogero
Biomedicines 2023, 11(12), 3260; https://doi.org/10.3390/biomedicines11123260 - 09 Dec 2023
Viewed by 1226
Abstract
Since its discovery, much attention has been drawn to irisin’s potential role in metabolic and reproductive diseases. This narrative review summarizes and updates the possible role played by this fascinating molecule in different physiological (puberty and menopause) and pathological (polycystic ovary syndrome (PCOS), [...] Read more.
Since its discovery, much attention has been drawn to irisin’s potential role in metabolic and reproductive diseases. This narrative review summarizes and updates the possible role played by this fascinating molecule in different physiological (puberty and menopause) and pathological (polycystic ovary syndrome (PCOS), functional hypothalamic amenorrhea (FHA), endometriosis, and gestational diabetes) conditions that can affect women throughout their entire lives. Irisin appears to be an important factor for the hypothalamic–pituitary–gonadal axis activation, and appears to play a role in the timing of puberty onset. Serum irisin levels have been proposed as a biomarker for predicting the future development of gestational diabetes (GDM). Its role in PCOS is still controversial, although an “irisin resistance” mechanism has been hypothesized. In addition to its impact on metabolism, irisin also appears to influence bone health. Irisin levels are inversely correlated with the prevalence of fractures in postmenopausal women. Similar mechanisms have also been postulated in young women with FHA. In clinical settings, further controlled, prospective and randomized clinical trials are needed to investigate the casual relationship between irisin levels and the conditions described and, in turn, to establish the role of irisin as a prognostic/diagnostic biomarker or a therapeutic target. Full article
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