Glomerular Microenvironment: Cellular Stress in Chronic Kidney Disease 2.0
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1874
Special Issue Editor
2. Bicêtre Hospital, Department of Nephrology, 94270 Le Kremlin-Bicêtre, France
3. INSERM U1197, 14 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
Interests: cell death; senescence; autophagy; DNA damage; stem cells; pathogenesis of renal disorder; molecular medicine; immunology of transplantation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is a global public health problem affecting people from all segments of society. The renal glomerulus (in particular, the filtration barrier) is the main target of these disorders. Its structure constitutes a special and unique microenvironment whose integrity is maintained by the molecular interaction between three central components: the endothelial cell, the basement membrane and the podocytes. This architecture must be finely preserved because its destabilization, through extraordinarily complex molecular mechanisms, can lead to the onset of severe proteinuria. This structural complexity limits the availability of reliable experimental models. Recent advances in regenerative medicine, organoids, as well as the design of microfluidic platforms or other devices, constitute promising models for the study of CKD.
This Special Issue is a continuation of a previous issue on this topic. It will serve as a report on the state of basic and translational research in the field of nephrotic syndrome pathogenesis: molecular mechanisms and new experimental models.
Dr. Hans-Kristian Lorenzo
Guest Editor
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Keywords
- chronic kidney disease
- nephrotic syndrome
- glomerular filtration barrier
- podocytes
- glomerular cell stress
- stem cells
- organoids
- regenerative medicine
