Dear Colleagues,

The primary objective of biomedical research is the mitigation of diseases. Over the last half-century, enormous amounts of resources have been invested in biomedical research with disappointing results: not a single major age-related disease (ARD) is curable, and the underlying mechanisms of aging and ARDs are insufficiently understood. In this Special Issue of Biomedicines, we present a different point of view on the etiology of aging and ARDs, and begin investigating simple approaches to alleviate them all at once by addressing their shared root cause rather than their downstream consequences.

Aging is the main risk factor for most chronic diseases and disorders that limit healthy life expectancy and lifespan. ARD incidence clearly increases exponentially with age and can be considered as part of the acceleration of the aging process. The concept of accelerated aging emerged from the observation of rare genetic syndromes such as Hutchinson‒Gilford progeria, in contrast to a small proportion of individuals, such as centenarians, who reach extreme age while avoiding or delaying most ARDs.

These remarkable individuals offer a demonstration that "healthy" aging and diseases can develop independently, as extreme phenotypes driven by a shared set of basic mechanisms. These are associated with adaptation to stress, loss of proteostasis, stem cell exhaustion, metabolism dysregulation, macromolecular damage, epigenetic modifications, and inflammation.

We cordially invite authors to submit original research and review articles that focus on these basic mechanisms that could uncover a common cause for Aging and ARDs.

Prof. Dr. Miroslav Radman
Dr. Guillaume Combes
Guest Editors

Manuscript Submission Information

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• aging
• age-related diseases
• protein oxidation
• proteostasis
• inflammation
• genetic and epigenetic alterations
• emerging phenotypes